SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4k2u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4001_1
(SERUM ALBUMIN)		 4k2u ANTIBODY LIGHT CHAIN
(Mus
musculus) 		4 / 5 ARG L  24
ALA L  25
ASP L  70
GLY L  68
 None
 1.10A 1e7bA-4k2uL:
undetectable		 1e7bA-4k2uL:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4001_1
(SERUM ALBUMIN)		 4k2u ANTIBODY LIGHT CHAIN
(Mus
musculus) 		4 / 5 ARG L  24
ALA L  25
ASP L  70
GLY L  68
 None
 1.03A 1e7cA-4k2uL:
undetectable		 1e7cA-4k2uL:
15.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1H8S_A_AICA1000_1
(MUTANT AL2 6E7P9G)		 4k2u ANTIBODY HEAVY CHAIN
ANTIBODY LIGHT CHAIN
(Mus
musculus) 		6 / 12 TYR L  36
GLN L  89
PHE L  98
VAL H  37
ALA H  93
TRP H 103
 None
 0.62A 1h8sA-4k2uL:
15.7		 1h8sA-4k2uL:
37.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4k2u ERYTHROCYTE BINDING
ANTIGEN 175
ANTIBODY HEAVY CHAIN
(Plasmodium
falciparum;
Mus
musculus) 		3 / 3 HIS A 159
ASP H  52
ASN H  32
 None
None
SO4  H 301 ( 4.8A)
 0.68A 1wg8B-4k2uA:
undetectable		 1wg8B-4k2uA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_G_BEZG3385_0
(CES1 PROTEIN)		 4k2u ANTIBODY LIGHT CHAIN
(Mus
musculus) 		3 / 3 SER L 177
VAL L 115
LEU L 136
 None
 0.73A 1yajG-4k2uL:
undetectable		 1yajG-4k2uL:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEO_A_017A402_2
(PROTEASE)		 4k2u ANTIBODY HEAVY CHAIN
(Mus
musculus) 		5 / 12 LEU H 138
VAL H 163
GLY H 157
VAL H 183
VAL H 181
 None
 0.92A 2ieoB-4k2uH:
undetectable		 2ieoB-4k2uH:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 4k2u ANTIBODY HEAVY CHAIN
ANTIBODY LIGHT CHAIN
(Mus
musculus;
Mus
musculus) 		3 / 3 THR H 182
ASP L 170
SER L 168
 None
 0.85A 2nxeA-4k2uH:
undetectable		 2nxeA-4k2uH:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		 4k2u ANTIBODY HEAVY CHAIN
ANTIBODY LIGHT CHAIN
ERYTHROCYTE BINDING
ANTIGEN 175
(Mus
musculus;
Plasmodium
falciparum) 		4 / 7 ARG L  53
TYR L  32
PHE H 100
GLU A 149
 None
 1.09A 2qebA-4k2uL:
undetectable		 2qebA-4k2uL:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		 4k2u ANTIBODY HEAVY CHAIN
ANTIBODY LIGHT CHAIN
ERYTHROCYTE BINDING
ANTIGEN 175
(Mus
musculus;
Plasmodium
falciparum) 		4 / 7 ARG L  53
TYR L  32
PHE H 100
GLU A 149
 None
 1.12A 2qebB-4k2uL:
undetectable		 2qebB-4k2uL:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4k2u ANTIBODY HEAVY CHAIN
ANTIBODY LIGHT CHAIN
(Mus
musculus) 		3 / 3 LEU L  46
TRP L  96
TYR H  96
 None
SO4  H 303 (-3.7A)
None
 0.91A 3aicA-4k2uL:
undetectable		 3aicA-4k2uL:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4k2u ANTIBODY HEAVY CHAIN
ANTIBODY LIGHT CHAIN
(Mus
musculus) 		3 / 3 LEU L  46
TRP L  96
TYR H  96
 None
SO4  H 303 (-3.7A)
None
 0.95A 3aicB-4k2uL:
undetectable		 3aicB-4k2uL:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4k2u ANTIBODY HEAVY CHAIN
ANTIBODY LIGHT CHAIN
(Mus
musculus) 		3 / 3 LEU L  46
TRP L  96
TYR H  96
 None
SO4  H 303 (-3.7A)
None
 0.95A 3aicE-4k2uL:
undetectable		 3aicE-4k2uL:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4k2u ANTIBODY HEAVY CHAIN
ANTIBODY LIGHT CHAIN
(Mus
musculus) 		3 / 3 LEU L  46
TRP L  96
TYR H  96
 None
SO4  H 303 (-3.7A)
None
 0.92A 3aicF-4k2uL:
undetectable		 3aicF-4k2uL:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4k2u ANTIBODY HEAVY CHAIN
ANTIBODY LIGHT CHAIN
(Mus
musculus) 		3 / 3 LEU L  46
TRP L  96
TYR H  96
 None
SO4  H 303 (-3.7A)
None
 0.89A 3aicG-4k2uL:
undetectable		 3aicG-4k2uL:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4k2u ANTIBODY HEAVY CHAIN
ANTIBODY LIGHT CHAIN
(Mus
musculus) 		3 / 3 LEU L  46
TRP L  96
TYR H  96
 None
SO4  H 303 (-3.7A)
None
 0.96A 3aicH-4k2uL:
undetectable		 3aicH-4k2uL:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_2
(ADENOSYLHOMOCYSTEINA
SE)		 4k2u ANTIBODY HEAVY CHAIN
(Mus
musculus) 		3 / 3 THR H 110
GLU H 148
HIS H 199
 None
 0.77A 3g1uB-4k2uH:
undetectable		 3g1uB-4k2uH:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_2
(PROTEASE)		 4k2u ANTIBODY HEAVY CHAIN
(Mus
musculus) 		5 / 10 LEU H 138
VAL H 163
GLY H 157
VAL H 183
VAL H 181
 None
 1.16A 3nu9B-4k2uH:
undetectable		 3nu9B-4k2uH:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB160_0
(HEME-BINDING PROTEIN
HUTZ)		 4k2u ANTIBODY LIGHT CHAIN
(Mus
musculus) 		4 / 4 LEU L  15
GLY L  16
LEU L  78
GLU L  79
 None
 0.88A 3tgvB-4k2uL:
undetectable		 3tgvB-4k2uL:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		 4k2u ANTIBODY HEAVY CHAIN
ANTIBODY LIGHT CHAIN
(Mus
musculus) 		3 / 3 PHE L  94
TYR H  33
TYR H 100
 SO4  H 303 (-4.6A)
SO4  H 303 (-4.3A)
SO4  H 303 (-4.4A)
 0.91A 4ffwA-4k2uL:
undetectable		 4ffwA-4k2uL:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_2
(DIHYDROFOLATE
REDUCTASE)		 4k2u ERYTHROCYTE BINDING
ANTIGEN 175
(Plasmodium
falciparum) 		3 / 3 TRP A 179
GLN A 171
THR A 177
 None
 1.04A 4m2xA-4k2uA:
undetectable		 4m2xA-4k2uA:
18.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UIL_H_QI9H1223_0
(FAB 314.1)		 4k2u ANTIBODY HEAVY CHAIN
ANTIBODY LIGHT CHAIN
(Mus
musculus;
Mus
musculus) 		5 / 12 HIS H  35
PHE H 100
GLN L  89
GLN L  90
GLY L  91
 None
 0.96A 4uilH-4k2uH:
25.8
4uilL-4k2uH:
16.5		 4uilH-4k2uH:
78.32
4uilL-4k2uH:
28.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4k2u ANTIBODY HEAVY CHAIN
(Mus
musculus) 		4 / 7 ILE H  51
ARG H  94
LEU H   4
ILE H  29
 None
SO4  H 301 (-2.8A)
None
None
 0.96A 4xumA-4k2uH:
undetectable		 4xumA-4k2uH:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y4D_A_CFFA411_1
(ENDOTHIAPEPSIN)		 4k2u ERYTHROCYTE BINDING
ANTIGEN 175
(Plasmodium
falciparum) 		4 / 6 LEU A 188
LEU A 270
PHE A 187
ILE A 180
 None
 1.27A 4y4dA-4k2uA:
undetectable		 4y4dA-4k2uA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KLA_A_ACTA1505_0
(MATERNAL PROTEIN
PUMILIO)		 4k2u ANTIBODY LIGHT CHAIN
(Mus
musculus) 		3 / 3 HIS L 198
LYS L 142
PHE L 139
 None
 1.49A 5klaA-4k2uL:
undetectable		 5klaA-4k2uL:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 4k2u ANTIBODY HEAVY CHAIN
ANTIBODY LIGHT CHAIN
(Mus
musculus;
Mus
musculus) 		5 / 12 GLY H  98
HIS H  95
HIS L  55
ARG L  53
LEU L  46
 None
None
SO4  L 301 (-3.8A)
None
None
 1.38A 5lsuB-4k2uH:
undetectable		 5lsuB-4k2uH:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4k2u ANTIBODY HEAVY CHAIN
(Mus
musculus) 		4 / 5 GLY H  55
ASN H  56
ASP H  52
ARG H  50
 None
None
None
SO4  H 303 (-3.3A)
 1.39A 6dwdB-4k2uH:
undetectable
6dwdD-4k2uH:
undetectable		 6dwdB-4k2uH:
17.32
6dwdD-4k2uH:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4k2u ANTIBODY HEAVY CHAIN
(Mus
musculus) 		4 / 5 ARG H  50
GLY H  55
ASN H  56
ASP H  52
 SO4  H 303 (-3.3A)
None
None
None
 1.40A 6dwjB-4k2uH:
undetectable
6dwjD-4k2uH:
undetectable		 6dwjB-4k2uH:
17.32
6dwjD-4k2uH:
17.32