SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4k2x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HBP_A_RTLA184_0
(RETINOL BINDING
PROTEIN)		 4k2x POLYKETIDE
OXYGENASE/HYDROXYLAS
E
(Streptomyces
rimosus) 		5 / 11 LEU A  31
PHE A 169
ALA A 275
VAL A 123
LEU A 151
 None
None
None
FAD  A 601 (-4.3A)
None
 1.20A 1hbpA-4k2xA:
undetectable		 1hbpA-4k2xA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG2_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 4k2x POLYKETIDE
OXYGENASE/HYDROXYLAS
E
(Streptomyces
rimosus) 		5 / 12 GLY A 153
LEU A 165
GLY A 156
ALA A   8
VAL A 123
 None
None
FAD  A 601 (-3.5A)
FAD  A 601 ( 4.3A)
FAD  A 601 (-4.3A)
 1.19A 1jg2A-4k2xA:
3.1		 1jg2A-4k2xA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_B_DIFB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4k2x POLYKETIDE
OXYGENASE/HYDROXYLAS
E
(Streptomyces
rimosus) 		5 / 9 VAL A 135
LEU A 126
LEU A 285
GLY A 153
ALA A   8
 None
None
None
None
FAD  A 601 ( 4.3A)
 1.23A 1pxxB-4k2xA:
undetectable		 1pxxB-4k2xA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_D_DIFD3701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4k2x POLYKETIDE
OXYGENASE/HYDROXYLAS
E
(Streptomyces
rimosus) 		5 / 10 VAL A 135
LEU A 126
LEU A 285
GLY A 153
ALA A   8
 None
None
None
None
FAD  A 601 ( 4.3A)
 1.23A 1pxxD-4k2xA:
undetectable		 1pxxD-4k2xA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC2_0
(ACTINOMYCIN D)		 4k2x POLYKETIDE
OXYGENASE/HYDROXYLAS
E
(Streptomyces
rimosus) 		3 / 3 THR A 138
PRO A 140
PRO A 143
 None
 0.89A 2d55C-4k2xA:
undetectable		 2d55C-4k2xA:
2.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4k2x POLYKETIDE
OXYGENASE/HYDROXYLAS
E
(Streptomyces
rimosus) 		4 / 5 LEU A  15
VAL A 133
LEU A 126
ARG A 279
 None
 1.01A 2oiqA-4k2xA:
undetectable		 2oiqA-4k2xA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4k2x POLYKETIDE
OXYGENASE/HYDROXYLAS
E
(Streptomyces
rimosus) 		4 / 4 TYR A  93
LEU A  70
LEU A  95
HIS A  91
 None
 1.36A 2x7hB-4k2xA:
2.3		 2x7hB-4k2xA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_2
(BETA-1 ADRENERGIC
RECEPTOR)		 4k2x POLYKETIDE
OXYGENASE/HYDROXYLAS
E
(Streptomyces
rimosus) 		3 / 3 VAL A 388
ASN A 310
TRP A 313
 None
 0.99A 2y00B-4k2xA:
undetectable		 2y00B-4k2xA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4k2x POLYKETIDE
OXYGENASE/HYDROXYLAS
E
(Streptomyces
rimosus) 		5 / 12 VAL A 283
ALA A 286
LEU A 311
ALA A 308
VAL A 133
 None
 0.97A 3fc6C-4k2xA:
undetectable		 3fc6C-4k2xA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG306_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4k2x POLYKETIDE
OXYGENASE/HYDROXYLAS
E
(Streptomyces
rimosus) 		3 / 3 ARG A 377
ARG A 401
ASP A  88
 None
 0.97A 3wipG-4k2xA:
undetectable
3wipH-4k2xA:
undetectable		 3wipG-4k2xA:
16.44
3wipH-4k2xA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOA_A_ACRA1587_2
(TREHALOSE
SYNTHASE/AMYLASE
TRES)		 4k2x POLYKETIDE
OXYGENASE/HYDROXYLAS
E
(Streptomyces
rimosus) 		3 / 3 ARG A 162
PHE A 169
PRO A 170
 None
 0.86A 3zoaB-4k2xA:
undetectable		 3zoaB-4k2xA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_A_IMNA201_1
(TRANSTHYRETIN)		 4k2x POLYKETIDE
OXYGENASE/HYDROXYLAS
E
(Streptomyces
rimosus) 		4 / 7 LEU A 113
ALA A 115
THR A  28
VAL A  30
 None
 0.98A 4ik7A-4k2xA:
undetectable		 4ik7A-4k2xA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB303_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN
S25-26 FAB (IGG1K)
LIGHT CHAIN)		 4k2x POLYKETIDE
OXYGENASE/HYDROXYLAS
E
(Streptomyces
rimosus) 		4 / 5 GLY A  62
ALA A  65
PHE A  63
GLU A  66
 None
 1.01A 4m93B-4k2xA:
undetectable
4m93C-4k2xA:
undetectable		 4m93B-4k2xA:
17.27
4m93C-4k2xA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_A_STRA601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 4k2x POLYKETIDE
OXYGENASE/HYDROXYLAS
E
(Streptomyces
rimosus) 		4 / 6 ALA A 275
GLY A 287
ILE A 167
VAL A 152
 None
FAD  A 601 (-3.5A)
None
None
 0.82A 4r21A-4k2xA:
undetectable		 4r21A-4k2xA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_B_STRB601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 4k2x POLYKETIDE
OXYGENASE/HYDROXYLAS
E
(Streptomyces
rimosus) 		5 / 9 ALA A 275
GLY A 287
ALA A 289
ILE A 167
VAL A 152
 None
FAD  A 601 (-3.5A)
None
None
None
 1.08A 4r21B-4k2xA:
undetectable		 4r21B-4k2xA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 4k2x POLYKETIDE
OXYGENASE/HYDROXYLAS
E
(Streptomyces
rimosus) 		4 / 6 ARG A 402
THR A  89
GLU A  52
ARG A 335
 None
 1.10A 5btaA-4k2xA:
undetectable
5btaB-4k2xA:
undetectable
5btaC-4k2xA:
undetectable		 5btaA-4k2xA:
23.58
5btaB-4k2xA:
21.92
5btaC-4k2xA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4k2x POLYKETIDE
OXYGENASE/HYDROXYLAS
E
(Streptomyces
rimosus) 		4 / 6 ARG A 402
THR A  89
GLU A  52
ARG A 335
 None
 1.06A 5btcA-4k2xA:
undetectable
5btcB-4k2xA:
undetectable
5btcC-4k2xA:
undetectable		 5btcA-4k2xA:
23.58
5btcB-4k2xA:
21.92
5btcC-4k2xA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4k2x POLYKETIDE
OXYGENASE/HYDROXYLAS
E
(Streptomyces
rimosus) 		5 / 12 VAL A 135
LEU A 126
LEU A 285
GLY A 153
ALA A   8
 None
None
None
None
FAD  A 601 ( 4.3A)
 1.24A 5iktB-4k2xA:
undetectable		 5iktB-4k2xA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 4k2x POLYKETIDE
OXYGENASE/HYDROXYLAS
E
(Streptomyces
rimosus) 		4 / 8 ILE A 338
GLN A 306
THR A  50
VAL A  51
 None
 0.97A 6fbvC-4k2xA:
undetectable		 6fbvC-4k2xA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_1
(-)		 4k2x POLYKETIDE
OXYGENASE/HYDROXYLAS
E
(Streptomyces
rimosus) 		5 / 12 ASP A 182
PHE A  40
GLN A  99
PRO A  98
GLY A  45
 None
None
FAD  A 601 (-3.2A)
None
FAD  A 601 ( 4.8A)
 1.32A 6gnfA-4k2xA:
undetectable		 6gnfA-4k2xA:
25.89