SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4k30'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_1
(VITAMIN D RECEPTOR)		 4k30 N-ACETYLGLUTAMATE
SYNTHASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 394
VAL A 395
SER A 398
LEU A 430
LEU A 411
 None
 1.11A 2hc4A-4k30A:
undetectable		 2hc4A-4k30A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 4k30 N-ACETYLGLUTAMATE
SYNTHASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 394
VAL A 395
SER A 398
LEU A 430
LEU A 411
 None
 1.19A 2zlcA-4k30A:
undetectable		 2zlcA-4k30A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTQ_A_FLPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4k30 N-ACETYLGLUTAMATE
SYNTHASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 TYR A 407
VAL A 395
VAL A 446
LEU A 383
LEU A 386
 None
 1.27A 4jtqA-4k30A:
undetectable		 4jtqA-4k30A:
20.41