SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4k35'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4k35 GLYCOSIDE HYDROLASE
FAMILY 81
ENDO-BETA-1,3-GLUCAN
ASE
(Rhizomucor
miehei) 		4 / 5 THR A 592
THR A 588
GLU A 647
THR A 645
 None
 1.30A 1d4fB-4k35A:
undetectable		 1d4fB-4k35A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGL_L_ESTL911_1
(IG GAMMA-1-CHAIN
IG KAPPA-CHAIN)		 4k35 GLYCOSIDE HYDROLASE
FAMILY 81
ENDO-BETA-1,3-GLUCAN
ASE
(Rhizomucor
miehei) 		5 / 10 GLY A 534
ALA A 274
LEU A 583
TYR A 284
PHE A   9
 None
 1.40A 1jglH-4k35A:
undetectable
1jglL-4k35A:
undetectable		 1jglH-4k35A:
13.47
1jglL-4k35A:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQW_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN)		 4k35 GLYCOSIDE HYDROLASE
FAMILY 81
ENDO-BETA-1,3-GLUCAN
ASE
(Rhizomucor
miehei) 		5 / 12 THR A 299
ARG A 590
LEU A 339
LEU A 137
ILE A 272
 None
 0.93A 1kqwA-4k35A:
undetectable		 1kqwA-4k35A:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_A_DMEA998_1
(ACETYLCHOLINESTERASE)		 4k35 GLYCOSIDE HYDROLASE
FAMILY 81
ENDO-BETA-1,3-GLUCAN
ASE
(Rhizomucor
miehei) 		5 / 12 ASP A 512
GLY A 481
GLU A 557
TRP A 505
PHE A 483
 None
None
TRS  A 801 (-3.4A)
None
None
 1.24A 1maaA-4k35A:
undetectable		 1maaA-4k35A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_A_SAMA401_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 4k35 GLYCOSIDE HYDROLASE
FAMILY 81
ENDO-BETA-1,3-GLUCAN
ASE
(Rhizomucor
miehei) 		5 / 12 THR A 506
GLY A 564
ASP A 512
VAL A 513
GLN A 480
 None
 1.31A 1n2xA-4k35A:
undetectable		 1n2xA-4k35A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_ACTH611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 4k35 GLYCOSIDE HYDROLASE
FAMILY 81
ENDO-BETA-1,3-GLUCAN
ASE
(Rhizomucor
miehei) 		4 / 6 TRP A 505
ASN A 498
LEU A 502
PHE A 427
 None
 1.45A 1ru9H-4k35A:
undetectable
1ru9L-4k35A:
undetectable		 1ru9H-4k35A:
14.79
1ru9L-4k35A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_L_ACTL611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 4k35 GLYCOSIDE HYDROLASE
FAMILY 81
ENDO-BETA-1,3-GLUCAN
ASE
(Rhizomucor
miehei) 		4 / 6 TRP A 505
ASN A 498
LEU A 502
PHE A 427
 None
 1.46A 1rukH-4k35A:
undetectable
1rukL-4k35A:
undetectable		 1rukH-4k35A:
14.79
1rukL-4k35A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_B_BEZB1503_0
(RAS-RELATED PROTEIN
RAB-9A)		 4k35 GLYCOSIDE HYDROLASE
FAMILY 81
ENDO-BETA-1,3-GLUCAN
ASE
(Rhizomucor
miehei) 		4 / 6 VAL A 484
GLU A 507
LEU A 509
ARG A 511
 None
 1.00A 1s8fB-4k35A:
undetectable		 1s8fB-4k35A:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDU_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 4k35 GLYCOSIDE HYDROLASE
FAMILY 81
ENDO-BETA-1,3-GLUCAN
ASE
(Rhizomucor
miehei) 		5 / 11 LEU A  50
GLY A 270
GLY A 269
PRO A  63
ILE A  47
 None
 0.81A 1sduA-4k35A:
undetectable		 1sduA-4k35A:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_D_NCTD1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4k35 GLYCOSIDE HYDROLASE
FAMILY 81
ENDO-BETA-1,3-GLUCAN
ASE
(Rhizomucor
miehei) 		4 / 8 TYR A  66
TYR A 163
LEU A 258
MET A 319
 None
 1.47A 1uw6D-4k35A:
undetectable
1uw6E-4k35A:
undetectable		 1uw6D-4k35A:
14.40
1uw6E-4k35A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_G_NCTG1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4k35 GLYCOSIDE HYDROLASE
FAMILY 81
ENDO-BETA-1,3-GLUCAN
ASE
(Rhizomucor
miehei) 		4 / 8 TYR A  66
TYR A 163
LEU A 258
MET A 319
 None
 1.48A 1uw6G-4k35A:
undetectable
1uw6H-4k35A:
undetectable		 1uw6G-4k35A:
14.40
1uw6H-4k35A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_P_NCTP1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4k35 GLYCOSIDE HYDROLASE
FAMILY 81
ENDO-BETA-1,3-GLUCAN
ASE
(Rhizomucor
miehei) 		4 / 8 TYR A  66
TYR A 163
LEU A 258
MET A 319
 None
 1.47A 1uw6P-4k35A:
undetectable
1uw6Q-4k35A:
undetectable		 1uw6P-4k35A:
14.40
1uw6Q-4k35A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_B_EV1B1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 4k35 GLYCOSIDE HYDROLASE
FAMILY 81
ENDO-BETA-1,3-GLUCAN
ASE
(Rhizomucor
miehei) 		4 / 8 LEU A 225
VAL A 247
ILE A 205
PHE A 175
 None
 0.89A 2weyB-4k35A:
2.7		 2weyB-4k35A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_A_KKKA413_1
(FLAVOHEMOGLOBIN)		 4k35 GLYCOSIDE HYDROLASE
FAMILY 81
ENDO-BETA-1,3-GLUCAN
ASE
(Rhizomucor
miehei) 		4 / 8 ILE A 372
GLN A 417
ALA A 399
LEU A 398
 None
 0.80A 3ozwA-4k35A:
undetectable		 3ozwA-4k35A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_D_NCAD302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 4k35 GLYCOSIDE HYDROLASE
FAMILY 81
ENDO-BETA-1,3-GLUCAN
ASE
(Rhizomucor
miehei) 		4 / 7 TYR A 625
LEU A 633
ASP A  98
TYR A 101
 None
None
TRS  A 802 (-3.7A)
None
 1.20A 3rodD-4k35A:
undetectable		 3rodD-4k35A:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SAN_A_ZMRA901_1
(NEURAMINIDASE)		 4k35 GLYCOSIDE HYDROLASE
FAMILY 81
ENDO-BETA-1,3-GLUCAN
ASE
(Rhizomucor
miehei) 		5 / 12 GLU A 383
ALA A 450
GLU A 467
ASN A 385
TYR A 430
 None
 1.49A 3sanA-4k35A:
undetectable		 3sanA-4k35A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTR_A_LQZA90_1
(LACTOTRANSFERRIN)		 4k35 GLYCOSIDE HYDROLASE
FAMILY 81
ENDO-BETA-1,3-GLUCAN
ASE
(Rhizomucor
miehei) 		3 / 3 PRO A  60
THR A  61
LEU A  70
 None
 0.77A 3ttrA-4k35A:
undetectable		 3ttrA-4k35A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4k35 GLYCOSIDE HYDROLASE
FAMILY 81
ENDO-BETA-1,3-GLUCAN
ASE
(Rhizomucor
miehei) 		4 / 6 THR A 242
ARG A 201
ILE A 245
LEU A 171
 None
 1.02A 4acbC-4k35A:
undetectable		 4acbC-4k35A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4k35 GLYCOSIDE HYDROLASE
FAMILY 81
ENDO-BETA-1,3-GLUCAN
ASE
(Rhizomucor
miehei) 		4 / 8 PRO A 296
ALA A 162
TYR A 163
SER A 262
 None
 1.04A 4k0bB-4k35A:
undetectable		 4k0bB-4k35A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4k35 GLYCOSIDE HYDROLASE
FAMILY 81
ENDO-BETA-1,3-GLUCAN
ASE
(Rhizomucor
miehei) 		4 / 8 PRO A 296
ALA A 162
TYR A 163
SER A 262
 None
 1.05A 4l7iB-4k35A:
undetectable		 4l7iB-4k35A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O4D_A_ACTA406_0
(INOSITOL
HEXAKISPHOSPHATE
KINASE)		 4k35 GLYCOSIDE HYDROLASE
FAMILY 81
ENDO-BETA-1,3-GLUCAN
ASE
(Rhizomucor
miehei) 		4 / 7 ASP A  98
THR A  96
ARG A 631
PHE A 632
 TRS  A 802 (-3.7A)
None
None
TRS  A 802 ( 4.0A)
 1.33A 4o4dA-4k35A:
1.4		 4o4dA-4k35A:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA205_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 4k35 GLYCOSIDE HYDROLASE
FAMILY 81
ENDO-BETA-1,3-GLUCAN
ASE
(Rhizomucor
miehei) 		5 / 12 PRO A  63
ASN A  49
ALA A 546
GLY A 545
LEU A 547
 None
 1.50A 4oadA-4k35A:
undetectable		 4oadA-4k35A:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_D_SAMD401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 4k35 GLYCOSIDE HYDROLASE
FAMILY 81
ENDO-BETA-1,3-GLUCAN
ASE
(Rhizomucor
miehei) 		5 / 12 GLY A 270
GLY A 269
ASP A 135
PHE A   9
ILE A 286
 None
 1.06A 4pghD-4k35A:
undetectable		 4pghD-4k35A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CVT_B_ACTB200_0
(N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
MUTASE)		 4k35 GLYCOSIDE HYDROLASE
FAMILY 81
ENDO-BETA-1,3-GLUCAN
ASE
(Rhizomucor
miehei) 		3 / 3 ASN A 689
ALA A 691
ARG A 724
 None
 0.57A 5cvtB-4k35A:
undetectable		 5cvtB-4k35A:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_A_5D5A930_1
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 4k35 GLYCOSIDE HYDROLASE
FAMILY 81
ENDO-BETA-1,3-GLUCAN
ASE
(Rhizomucor
miehei) 		4 / 6 SER A 374
TYR A 376
LYS A 394
PHE A 395
 None
 1.11A 5dlvA-4k35A:
0.8		 5dlvA-4k35A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_B_5D5B927_1
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 4k35 GLYCOSIDE HYDROLASE
FAMILY 81
ENDO-BETA-1,3-GLUCAN
ASE
(Rhizomucor
miehei) 		4 / 7 SER A 374
TYR A 376
LYS A 394
PHE A 395
 None
 1.14A 5dlvB-4k35A:
undetectable		 5dlvB-4k35A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_H_SAMH301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4k35 GLYCOSIDE HYDROLASE
FAMILY 81
ENDO-BETA-1,3-GLUCAN
ASE
(Rhizomucor
miehei) 		5 / 12 ASP A 512
ASP A 384
GLY A 389
THR A 380
TYR A 482
 None
 1.40A 5hfjH-4k35A:
undetectable		 5hfjH-4k35A:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4k35 GLYCOSIDE HYDROLASE
FAMILY 81
ENDO-BETA-1,3-GLUCAN
ASE
(Rhizomucor
miehei) 		3 / 3 ARG A 440
ILE A 448
PHE A  21
 None
 0.55A 5kirA-4k35A:
undetectable		 5kirA-4k35A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4k35 GLYCOSIDE HYDROLASE
FAMILY 81
ENDO-BETA-1,3-GLUCAN
ASE
(Rhizomucor
miehei) 		4 / 5 ASN A 515
ASP A 520
ASN A  14
ASP A  16
 None
 1.49A 5vooE-4k35A:
undetectable		 5vooE-4k35A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZOV_B_ASCB501_0
(PTS
ASCORBATE-SPECIFIC
SUBUNIT IIBC)		 4k35 GLYCOSIDE HYDROLASE
FAMILY 81
ENDO-BETA-1,3-GLUCAN
ASE
(Rhizomucor
miehei) 		5 / 12 PRO A  63
ILE A  82
ALA A 166
ILE A 157
MET A 161
 None
 1.14A 5zovB-4k35A:
undetectable		 5zovB-4k35A:
21.00