SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4k3c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA355_1
(PROTEIN (ADENOSINE
KINASE))		 4k3c OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
([Haemophilus]
ducreyi) 		5 / 12 GLY A 313
ARG A 312
ALA A 340
GLY A 341
ALA A 317
 None
 0.94A 1bx4A-4k3cA:
undetectable		 1bx4A-4k3cA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_1
(PROTEIN (HIV-1
PROTEASE))		 4k3c OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
([Haemophilus]
ducreyi) 		5 / 10 ALA A 498
ASP A 685
ILE A 687
GLY A 668
ILE A 667
 None
 1.14A 1d4yA-4k3cA:
undetectable		 1d4yA-4k3cA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HO5_B_ADNB2604_1
(5'-NUCLEOTIDASE)		 4k3c OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
([Haemophilus]
ducreyi) 		5 / 10 ASN A 424
SER A 791
GLY A 790
ASN A 438
GLY A 764
 None
 1.47A 1ho5B-4k3cA:
undetectable		 1ho5B-4k3cA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J1G_F_SC2F1290_1
(FICOLIN-2)		 4k3c OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
([Haemophilus]
ducreyi) 		5 / 10 SER A 566
LEU A 534
ASP A 532
ASP A 568
THR A 530
 None
 1.34A 2j1gE-4k3cA:
undetectable
2j1gF-4k3cA:
undetectable		 2j1gE-4k3cA:
19.51
2j1gF-4k3cA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DHID8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 4k3c OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
([Haemophilus]
ducreyi) 		4 / 4 SER A 422
GLY A 421
GLY A 440
GLY A 454
 None
 0.81A 3bogB-4k3cA:
undetectable
3bogD-4k3cA:
undetectable		 3bogB-4k3cA:
undetectable
3bogD-4k3cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_0
(PCZA361.24)		 4k3c OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
([Haemophilus]
ducreyi) 		5 / 12 ALA A 653
GLY A 665
MET A 692
GLY A 657
SER A 658
 None
 1.07A 3g2oA-4k3cA:
undetectable		 3g2oA-4k3cA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_B_SAMB600_0
(PCZA361.24)		 4k3c OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
([Haemophilus]
ducreyi) 		5 / 12 ALA A 653
GLY A 665
MET A 692
GLY A 657
SER A 658
 None
 1.08A 3g2oB-4k3cA:
undetectable		 3g2oB-4k3cA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 4k3c OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
([Haemophilus]
ducreyi) 		5 / 10 LYS A 776
SER A 666
ILE A 782
PRO A 773
GLY A 661
 None
 1.11A 3ijxB-4k3cA:
undetectable
3ijxD-4k3cA:
undetectable		 3ijxB-4k3cA:
20.24
3ijxD-4k3cA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB262_1
(GLUTAMATE RECEPTOR 2)		 4k3c OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
([Haemophilus]
ducreyi) 		5 / 10 ILE A 782
PRO A 773
GLY A 661
LYS A 776
SER A 666
 None
 1.09A 3ik6B-4k3cA:
undetectable
3ik6E-4k3cA:
undetectable		 3ik6B-4k3cA:
20.24
3ik6E-4k3cA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 4k3c OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
([Haemophilus]
ducreyi) 		5 / 10 LYS A 776
SER A 666
ILE A 782
PRO A 773
GLY A 661
 None
 1.11A 3ik6B-4k3cA:
undetectable
3ik6E-4k3cA:
undetectable		 3ik6B-4k3cA:
20.24
3ik6E-4k3cA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		 4k3c OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
([Haemophilus]
ducreyi) 		5 / 10 LYS A 776
SER A 666
ILE A 782
PRO A 773
GLY A 661
 None
 1.09A 3iluB-4k3cA:
undetectable
3iluE-4k3cA:
undetectable		 3iluB-4k3cA:
20.24
3iluE-4k3cA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		 4k3c OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
([Haemophilus]
ducreyi) 		5 / 11 ILE A 782
PRO A 773
GLY A 661
LYS A 776
SER A 666
 None
 1.05A 3iluB-4k3cA:
undetectable
3iluE-4k3cA:
undetectable		 3iluB-4k3cA:
20.24
3iluE-4k3cA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_2
(SUGAR KINASE)		 4k3c OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
([Haemophilus]
ducreyi) 		3 / 3 SER A 590
TYR A 577
PRO A 586
 None
 0.93A 4k8cA-4k3cA:
undetectable		 4k8cA-4k3cA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4k3c OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
([Haemophilus]
ducreyi) 		3 / 3 SER A 590
TYR A 577
PRO A 586
 None
 0.91A 4kahA-4k3cA:
undetectable		 4kahA-4k3cA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4k3c OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
([Haemophilus]
ducreyi) 		3 / 3 SER A 590
TYR A 577
PRO A 586
 None
 0.91A 4kahB-4k3cA:
undetectable		 4kahB-4k3cA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4k3c OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
([Haemophilus]
ducreyi) 		3 / 3 SER A 590
TYR A 577
PRO A 586
 None
 0.94A 4kanA-4k3cA:
undetectable		 4kanA-4k3cA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4k3c OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
([Haemophilus]
ducreyi) 		3 / 3 SER A 590
TYR A 577
PRO A 586
 None
 0.92A 4kanB-4k3cA:
undetectable		 4kanB-4k3cA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4k3c OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
([Haemophilus]
ducreyi) 		3 / 3 SER A 590
TYR A 577
PRO A 586
 None
 0.91A 4kbeA-4k3cA:
undetectable		 4kbeA-4k3cA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4k3c OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
([Haemophilus]
ducreyi) 		3 / 3 SER A 590
TYR A 577
PRO A 586
 None
 0.92A 4kbeB-4k3cA:
undetectable		 4kbeB-4k3cA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4k3c OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
([Haemophilus]
ducreyi) 		3 / 3 SER A 590
TYR A 577
PRO A 586
 None
 0.91A 4lbgA-4k3cA:
undetectable		 4lbgA-4k3cA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4k3c OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
([Haemophilus]
ducreyi) 		3 / 3 SER A 590
TYR A 577
PRO A 586
 None
 0.91A 4lbgB-4k3cA:
undetectable		 4lbgB-4k3cA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M5M_A_DX4A401_0
(2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE)		 4k3c OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
([Haemophilus]
ducreyi) 		4 / 8 GLY A 448
THR A 420
ASN A 445
PHE A 391
 None
 1.22A 4m5mA-4k3cA:
undetectable		 4m5mA-4k3cA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4k3c OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
([Haemophilus]
ducreyi) 		4 / 8 GLU A 538
GLU A 540
TYR A 541
TYR A 648
 None
 1.18A 4mj8A-4k3cA:
undetectable
4mj8C-4k3cA:
undetectable		 4mj8A-4k3cA:
16.76
4mj8C-4k3cA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4k3c OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
([Haemophilus]
ducreyi) 		4 / 5 ILE A 412
ASP A 359
GLU A 352
VAL A 395
 None
 1.14A 4nkxC-4k3cA:
undetectable		 4nkxC-4k3cA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4k3c OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
([Haemophilus]
ducreyi) 		4 / 5 ILE A 412
ASP A 359
GLU A 352
VAL A 395
 None
 1.17A 4nkxD-4k3cA:
undetectable		 4nkxD-4k3cA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 4k3c OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
([Haemophilus]
ducreyi) 		5 / 12 ALA A 498
GLY A 654
ASP A 780
ALA A 723
ALA A 653
 None
 1.06A 4pclA-4k3cA:
undetectable		 4pclA-4k3cA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4k3c OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
([Haemophilus]
ducreyi) 		5 / 11 THR A 724
ALA A 723
GLY A 689
GLY A 688
SER A 652
 None
 1.08A 4qvwY-4k3cA:
undetectable
4qvwZ-4k3cA:
undetectable		 4qvwY-4k3cA:
16.14
4qvwZ-4k3cA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_A_ACTA1231_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT)		 4k3c OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
([Haemophilus]
ducreyi) 		3 / 3 ARG A 496
THR A 461
ASP A 462
 None
 0.89A 5g5gA-4k3cA:
undetectable
5g5gB-4k3cA:
undetectable		 5g5gA-4k3cA:
17.55
5g5gB-4k3cA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 4k3c OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
([Haemophilus]
ducreyi) 		5 / 12 PHE A 662
GLY A 655
SER A 769
GLN A 786
ALA A 723
 None
 1.14A 5kpcB-4k3cA:
undetectable		 5kpcB-4k3cA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 4k3c OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
([Haemophilus]
ducreyi) 		5 / 12 PHE A 662
GLY A 657
GLY A 655
SER A 769
GLN A 786
 None
 1.04A 5kpcB-4k3cA:
undetectable		 5kpcB-4k3cA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_1
(PROTEASE PR5-SQV)		 4k3c OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
([Haemophilus]
ducreyi) 		5 / 9 ALA A 498
ASP A 685
ILE A 687
GLY A 668
ILE A 667
 None
 1.29A 5kr2A-4k3cA:
undetectable		 5kr2A-4k3cA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_1
(PROTEASE PR5-SQV)		 4k3c OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
([Haemophilus]
ducreyi) 		5 / 9 ALA A 498
ASP A 685
ILE A 687
GLY A 668
ILE A 667
 None
 1.24A 5kr2C-4k3cA:
undetectable		 5kr2C-4k3cA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_I_BEZI1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 4k3c OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
([Haemophilus]
ducreyi) 		3 / 3 SER A 639
TYR A 607
TYR A 608
 None
 0.78A 5lakA-4k3cA:
undetectable
5lakI-4k3cA:
undetectable		 5lakA-4k3cA:
19.35
5lakI-4k3cA:
2.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_J_BEZJ1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 4k3c OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
([Haemophilus]
ducreyi) 		3 / 3 SER A 639
TYR A 607
TYR A 608
 None
 0.73A 5lakC-4k3cA:
undetectable
5lakJ-4k3cA:
undetectable		 5lakC-4k3cA:
19.35
5lakJ-4k3cA:
2.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_1
(REGULATORY PROTEIN
TETR)		 4k3c OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
([Haemophilus]
ducreyi) 		4 / 7 GLY A 661
ILE A 667
GLN A 684
ASP A 780
 None
 1.05A 5vlmC-4k3cA:
undetectable		 5vlmC-4k3cA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_1
(REGULATORY PROTEIN
TETR)		 4k3c OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
([Haemophilus]
ducreyi) 		4 / 8 GLY A 661
ILE A 667
GLN A 684
ASP A 780
 None
 1.07A 5vlmD-4k3cA:
undetectable		 5vlmD-4k3cA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7B_B_PA1B204_1
(ACYLOXYACYL
HYDROLASE SMALL
SUBUNIT
ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT)		 4k3c OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
([Haemophilus]
ducreyi) 		3 / 3 GLY A 448
ASN A 445
ARG A 364
 None
 0.68A 5w7bD-4k3cA:
undetectable		 5w7bD-4k3cA:
9.68