SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4k3d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD8_0
(GRAMICIDIN A)		 4k3d BOVINE ANTIBODY WITH
ULTRALONG CDR H3,
HEAVY CHAIN
(Bos
taurus) 		3 / 3 VAL H 101
VAL H  34
TRP H 101
 None
 0.89A 1av2C-4k3dH:
undetectable
1av2D-4k3dH:
undetectable		 1av2C-4k3dH:
5.62
1av2D-4k3dH:
5.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7W_A_MTXA301_1
(PTERIDINE REDUCTASE)		 4k3d BOVINE ANTIBODY WITH
ULTRALONG CDR H3,
HEAVY CHAIN
(Bos
taurus) 		5 / 12 ARG H  66
PRO H  41
LEU H  20
LEU H  18
ASP H  86
 None
 1.28A 1e7wA-4k3dH:
undetectable		 1e7wA-4k3dH:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_D_DVAD8_0
(GRAMICIDIN D)		 4k3d BOVINE ANTIBODY WITH
ULTRALONG CDR H3,
HEAVY CHAIN
(Bos
taurus) 		3 / 3 VAL H 101
VAL H  34
TRP H 101
 None
 0.85A 1w5uC-4k3dH:
undetectable
1w5uD-4k3dH:
undetectable		 1w5uC-4k3dH:
5.62
1w5uD-4k3dH:
5.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_A_5FWA601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4k3d BOVINE ANTIBODY WITH
ULTRALONG CDR H3,
HEAVY CHAIN
(Bos
taurus) 		5 / 12 VAL H 163
VAL H 182
SER H 180
ASN H 196
ASN H 155
 None
 1.45A 2y03A-4k3dH:
undetectable		 2y03A-4k3dH:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_B_5FWB601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4k3d BOVINE ANTIBODY WITH
ULTRALONG CDR H3,
HEAVY CHAIN
(Bos
taurus) 		5 / 12 VAL H 163
VAL H 182
SER H 180
ASN H 196
ASN H 155
 None
 1.49A 2y03B-4k3dH:
undetectable		 2y03B-4k3dH:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA2_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 4k3d BOVINE ANTIBODY WITH
ULTRALONG CDR H3,
HEAVY CHAIN
(Bos
taurus) 		3 / 3 LYS H 208
LYS H 120
VAL H 121
 None
 1.00A 3brfA-4k3dH:
2.3		 3brfA-4k3dH:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD8_0
(GRAMICIDIN D)		 4k3d BOVINE ANTIBODY WITH
ULTRALONG CDR H3,
HEAVY CHAIN
(Bos
taurus) 		3 / 3 VAL H 101
VAL H  34
TRP H 101
 None
 0.88A 3l8lC-4k3dH:
undetectable
3l8lD-4k3dH:
undetectable		 3l8lC-4k3dH:
5.62
3l8lD-4k3dH:
5.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OF4_B_ACTB313_0
(NITROREDUCTASE)		 4k3d BOVINE ANTIBODY WITH
ULTRALONG CDR H3,
HEAVY CHAIN
(Bos
taurus) 		3 / 3 ALA H 168
VAL H 169
GLN H 171
 None
 0.60A 3of4B-4k3dH:
undetectable		 3of4B-4k3dH:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_B_IMNB201_1
(TRANSTHYRETIN)		 4k3d BOVINE ANTIBODY WITH
ULTRALONG CDR H3,
HEAVY CHAIN
(Bos
taurus) 		4 / 6 LYS H  13
LEU H  11
SER H  87
THR H  84
 None
 1.06A 4ikiB-4k3dH:
undetectable		 4ikiB-4k3dH:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 4k3d BOVINE ANTIBODY WITH
ULTRALONG CDR H3,
HEAVY CHAIN
(Bos
taurus) 		5 / 11 VAL H 206
THR H 204
VAL H 210
ALA H 118
VAL H 152
 None
 1.21A 6dryA-4k3dH:
undetectable		 6dryA-4k3dH:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7M_B_68HB405_0
(BETA-1 ADRENERGIC
RECEPTOR)		 4k3d BOVINE ANTIBODY WITH
ULTRALONG CDR H3,
HEAVY CHAIN
(Bos
taurus) 		5 / 12 VAL H 163
VAL H 182
SER H 180
ASN H 196
ASN H 155
 None
 1.45A 6h7mB-4k3dH:
undetectable		 6h7mB-4k3dH:
15.48