SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4k3e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L4N_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4k3e BOVINE ANTIBODY WITH
ULTRALONG CDR H3,
HEAVY CHAIN
(Bos
taurus) 		5 / 9 GLY H 106
LEU H  20
GLU H   6
ARG H   5
GLY H   8
 None
 1.20A 1l4nA-4k3eH:
undetectable		 1l4nA-4k3eH:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5L_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4k3e BOVINE ANTIBODY WITH
ULTRALONG CDR H3,
HEAVY CHAIN
(Bos
taurus) 		5 / 9 GLY H 106
LEU H  20
GLU H   6
ARG H   5
GLY H   8
 None
 1.18A 1l5lA-4k3eH:
undetectable		 1l5lA-4k3eH:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5M_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4k3e BOVINE ANTIBODY WITH
ULTRALONG CDR H3,
HEAVY CHAIN
(Bos
taurus) 		5 / 9 GLY H 106
LEU H  20
GLU H   6
ARG H   5
GLY H   8
 None
 1.17A 1l5mA-4k3eH:
undetectable		 1l5mA-4k3eH:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_A_5FWA601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4k3e BOVINE ANTIBODY WITH
ULTRALONG CDR H3,
HEAVY CHAIN
(Bos
taurus) 		5 / 12 VAL H 163
VAL H 182
SER H 180
ASN H 196
ASN H 155
 None
 1.40A 2y03A-4k3eH:
undetectable		 2y03A-4k3eH:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_B_5FWB601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4k3e BOVINE ANTIBODY WITH
ULTRALONG CDR H3,
HEAVY CHAIN
(Bos
taurus) 		5 / 12 VAL H 163
VAL H 182
SER H 180
ASN H 196
ASN H 155
 None
 1.43A 2y03B-4k3eH:
undetectable		 2y03B-4k3eH:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA2_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 4k3e BOVINE ANTIBODY WITH
ULTRALONG CDR H3,
HEAVY CHAIN
(Bos
taurus) 		3 / 3 LYS H 208
LYS H 120
VAL H 121
 None
 0.97A 3brfA-4k3eH:
2.8		 3brfA-4k3eH:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NYA_A_JTZA1203_1
(BETA-2 ADRENERGIC
RECEPTOR, LYSOZYME)		 4k3e BOVINE ANTIBODY WITH
ULTRALONG CDR H3,
HEAVY CHAIN
(Bos
taurus) 		5 / 12 VAL H 163
VAL H 182
SER H 180
ASN H 196
ASN H 155
 None
 1.41A 3nyaA-4k3eH:
undetectable		 3nyaA-4k3eH:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_0
(2'-O-METHYL
TRANSFERASE)		 4k3e BOVINE ANTIBODY WITH
ULTRALONG CDR H3,
HEAVY CHAIN
(Bos
taurus) 		5 / 12 GLY H 139
SER H 125
PRO H 212
LEU H 141
PHE H 166
 None
 1.28A 3r24A-4k3eH:
undetectable		 3r24A-4k3eH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQI_A_NIOA403_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4k3e BOVINE ANTIBODY WITH
ULTRALONG CDR H3,
HEAVY CHAIN
(Bos
taurus) 		5 / 9 GLY H 106
LEU H  20
GLU H   6
ARG H   5
GLY H   8
 None
 1.24A 4kqiA-4k3eH:
undetectable		 4kqiA-4k3eH:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4k3e BOVINE ANTIBODY WITH
ULTRALONG CDR H3,
HEAVY CHAIN
(Bos
taurus) 		3 / 3 SER H 203
ALA H 198
VAL H 197
 None
 0.59A 4x1iA-4k3eH:
undetectable		 4x1iA-4k3eH:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_2
(THYROXINE-BINDING
GLOBULIN)		 4k3e BOVINE ANTIBODY WITH
ULTRALONG CDR H3,
HEAVY CHAIN
(Bos
taurus) 		3 / 3 LEU H 107
ARG H 105
ARG H   5
 None
 0.95A 4yiaB-4k3eH:
undetectable		 4yiaB-4k3eH:
6.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4k3e BOVINE ANTIBODY WITH
ULTRALONG CDR H3,
HEAVY CHAIN
(Bos
taurus) 		3 / 3 SER H 203
ALA H 198
VAL H 197
 None
 0.55A 5eypA-4k3eH:
undetectable		 5eypA-4k3eH:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA CHAIN)		 4k3e BOVINE ANTIBODY WITH
ULTRALONG CDR H3,
HEAVY CHAIN
(Bos
taurus) 		3 / 3 SER H 203
ALA H 198
VAL H 197
 None
 0.52A 5xiwC-4k3eH:
undetectable		 5xiwC-4k3eH:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 4k3e BOVINE ANTIBODY WITH
ULTRALONG CDR H3,
HEAVY CHAIN
(Bos
taurus) 		5 / 11 VAL H 206
THR H 204
VAL H 210
ALA H 118
VAL H 152
 None
 1.07A 6dryA-4k3eH:
undetectable		 6dryA-4k3eH:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7M_B_68HB405_0
(BETA-1 ADRENERGIC
RECEPTOR)		 4k3e BOVINE ANTIBODY WITH
ULTRALONG CDR H3,
HEAVY CHAIN
(Bos
taurus) 		5 / 12 VAL H 163
VAL H 182
SER H 180
ASN H 196
ASN H 155
 None
 1.46A 6h7mB-4k3eH:
undetectable		 6h7mB-4k3eH:
16.24