SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4k3f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AM6_A_HAEA555_1
(CARBONIC ANHYDRASE)		 4k3f PROBABLE
TONB-DEPENDENT
RECEPTOR
(Pseudomonas
aeruginosa) 		4 / 7 HIS A 101
HIS A  34
LEU A 196
THR A 192
 None
 1.05A 1am6A-4k3fA:
undetectable		 1am6A-4k3fA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 4k3f PROBABLE
TONB-DEPENDENT
RECEPTOR
(Pseudomonas
aeruginosa) 		4 / 4 ILE A 126
LEU A 115
VAL A 145
ILE A 168
 None
 0.85A 1fm6D-4k3fA:
undetectable		 1fm6D-4k3fA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_E_REAE176_1
(RETINOL BINDING
PROTEIN)		 4k3f PROBABLE
TONB-DEPENDENT
RECEPTOR
(Pseudomonas
aeruginosa) 		5 / 10 ALA A 231
VAL A  27
MET A 232
LEU A 220
ASP A 225
 None
 1.01A 1rlbE-4k3fA:
undetectable		 1rlbE-4k3fA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_A_SCKA901_1
(ACETYLCHOLINESTERASE)		 4k3f PROBABLE
TONB-DEPENDENT
RECEPTOR
(Pseudomonas
aeruginosa) 		4 / 8 ASP A  59
TYR A 194
TYR A  82
HIS A  79
 None
 1.48A 2ha2A-4k3fA:
undetectable		 2ha2A-4k3fA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_B_SCKB951_1
(ACETYLCHOLINESTERASE)		 4k3f PROBABLE
TONB-DEPENDENT
RECEPTOR
(Pseudomonas
aeruginosa) 		4 / 8 ASP A  59
TYR A 194
TYR A  82
HIS A  79
 None
 1.44A 2ha2B-4k3fA:
undetectable		 2ha2B-4k3fA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M9Q_B_BEZB251_0
(SERINE PROTEASE
INHIBITOR
SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3)		 4k3f PROBABLE
TONB-DEPENDENT
RECEPTOR
(Pseudomonas
aeruginosa) 		5 / 9 LEU A 139
ILE A 146
VAL A 145
ALA A 208
LEU A 189
 None
 1.05A 2m9qA-4k3fA:
undetectable		 2m9qA-4k3fA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA2_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 4k3f PROBABLE
TONB-DEPENDENT
RECEPTOR
(Pseudomonas
aeruginosa) 		3 / 3 LYS A 234
LYS A   0
VAL A  50
 None
 0.99A 3brfA-4k3fA:
undetectable		 3brfA-4k3fA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4k3f PROBABLE
TONB-DEPENDENT
RECEPTOR
(Pseudomonas
aeruginosa) 		4 / 7 SER A 212
LEU A 196
ARG A 135
ILE A 209
 None
 1.01A 3ln1C-4k3fA:
undetectable		 3ln1C-4k3fA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_A_DESA601_1
(ESTROGEN RECEPTOR)		 4k3f PROBABLE
TONB-DEPENDENT
RECEPTOR
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 143
LEU A 189
LEU A 139
LEU A 138
LEU A 115
 None
 1.03A 4zn7A-4k3fA:
undetectable		 4zn7A-4k3fA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQY_A_BEZA401_0
(THIOREDOXIN)		 4k3f PROBABLE
TONB-DEPENDENT
RECEPTOR
(Pseudomonas
aeruginosa) 		4 / 8 ILE A  37
PHE A 247
GLN A 249
GLU A 250
 None
 1.04A 5dqyA-4k3fA:
undetectable		 5dqyA-4k3fA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_A_ILEA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4k3f PROBABLE
TONB-DEPENDENT
RECEPTOR
(Pseudomonas
aeruginosa) 		4 / 6 ALA A  29
VAL A  27
VAL A 100
HIS A  34
 None
 1.04A 5eclA-4k3fA:
undetectable		 5eclA-4k3fA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 4k3f PROBABLE
TONB-DEPENDENT
RECEPTOR
(Pseudomonas
aeruginosa) 		4 / 6 TYR A 216
TYR A  60
GLY A 133
ASP A 160
 None
 1.25A 5emlA-4k3fA:
undetectable		 5emlA-4k3fA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4k3f PROBABLE
TONB-DEPENDENT
RECEPTOR
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 126
LEU A 115
VAL A 145
ILE A 168
LEU A 200
 None
 1.04A 5ycnA-4k3fA:
undetectable		 5ycnA-4k3fA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4k3f PROBABLE
TONB-DEPENDENT
RECEPTOR
(Pseudomonas
aeruginosa) 		4 / 6 TYR A  82
GLN A  62
VAL A  65
ALA A 130
 None
 1.24A 6djzB-4k3fA:
undetectable		 6djzB-4k3fA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F5U_A_CQNA610_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 4k3f PROBABLE
TONB-DEPENDENT
RECEPTOR
(Pseudomonas
aeruginosa) 		5 / 10 VAL A  27
ALA A  29
LEU A 235
LEU A 239
LEU A  52
 None
 0.98A 6f5uA-4k3fA:
undetectable
6f5uB-4k3fA:
undetectable		 6f5uA-4k3fA:
15.18
6f5uB-4k3fA:
16.67