SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4k3g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4k3g IMMUNOGLOBULIN
LAMBDA VARIABLE
DOMAIN L5(L89S)
(Homo
sapiens) 		5 / 12 GLY A  24
VAL A   3
ALA A  72
TRP A  35
GLY A 100
 None
 1.10A 1kiaA-4k3gA:
undetectable		 1kiaA-4k3gA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4k3g IMMUNOGLOBULIN
LAMBDA VARIABLE
DOMAIN L5(L89S)
(Homo
sapiens) 		5 / 12 GLY A  24
VAL A   3
ALA A  72
TRP A  35
GLY A 100
 None
 1.09A 1kiaB-4k3gA:
undetectable		 1kiaB-4k3gA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4k3g IMMUNOGLOBULIN
LAMBDA VARIABLE
DOMAIN L5(L89S)
(Homo
sapiens) 		5 / 12 GLY A  24
VAL A   3
ALA A  72
TRP A  35
GLY A 100
 None
 1.09A 1kiaC-4k3gA:
undetectable		 1kiaC-4k3gA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4k3g IMMUNOGLOBULIN
LAMBDA VARIABLE
DOMAIN L5(L89S)
(Homo
sapiens) 		5 / 12 GLY A  24
VAL A   3
ALA A  72
TRP A  35
GLY A 100
 None
 1.01A 1nbiA-4k3gA:
undetectable		 1nbiA-4k3gA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4k3g IMMUNOGLOBULIN
LAMBDA VARIABLE
DOMAIN L5(L89S)
(Homo
sapiens) 		5 / 12 GLY A  24
VAL A   3
ALA A  72
TRP A  35
GLY A 100
 None
 1.02A 1nbiB-4k3gA:
undetectable		 1nbiB-4k3gA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_2_BO221405_1
(PROTEASOME COMPONENT
PRE3)		 4k3g IMMUNOGLOBULIN
LAMBDA VARIABLE
DOMAIN L5(L89S)
(Homo
sapiens) 		5 / 11 THR A 102
THR A  22
THR A  74
ALA A  72
SER A   9
 None
 1.16A 2f162-4k3gA:
undetectable		 2f162-4k3gA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 4k3g IMMUNOGLOBULIN
LAMBDA VARIABLE
DOMAIN L5(L89S)
(Homo
sapiens) 		5 / 11 THR A 102
THR A  22
THR A  74
ALA A  72
SER A   9
 None
 1.16A 2f16N-4k3gA:
undetectable		 2f16N-4k3gA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX2_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4k3g IMMUNOGLOBULIN
LAMBDA VARIABLE
DOMAIN L5(L89S)
(Homo
sapiens) 		4 / 7 VAL A 106
ARG A  61
VAL A  19
GLU A  83
 None
 1.25A 3jx2A-4k3gA:
undetectable
3jx2B-4k3gA:
undetectable		 3jx2A-4k3gA:
14.86
3jx2B-4k3gA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX5_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4k3g IMMUNOGLOBULIN
LAMBDA VARIABLE
DOMAIN L5(L89S)
(Homo
sapiens) 		4 / 7 VAL A 106
ARG A  61
VAL A  19
GLU A  83
 None
 1.26A 3jx5A-4k3gA:
undetectable
3jx5B-4k3gA:
undetectable		 3jx5A-4k3gA:
14.86
3jx5B-4k3gA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX6_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4k3g IMMUNOGLOBULIN
LAMBDA VARIABLE
DOMAIN L5(L89S)
(Homo
sapiens) 		4 / 7 VAL A 106
ARG A  61
VAL A  19
GLU A  83
 None
 1.23A 3jx6A-4k3gA:
undetectable
3jx6B-4k3gA:
undetectable		 3jx6A-4k3gA:
14.86
3jx6B-4k3gA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_2_BO221405_1
(PROTEASOME COMPONENT
PRE3
PROTEASOME COMPONENT
PUP1)		 4k3g IMMUNOGLOBULIN
LAMBDA VARIABLE
DOMAIN L5(L89S)
(Homo
sapiens) 		5 / 12 THR A 102
THR A  22
THR A  74
ALA A  72
SER A   9
 None
 1.20A 3mg02-4k3gA:
undetectable
3mg0V-4k3gA:
undetectable		 3mg02-4k3gA:
21.78
3mg0V-4k3gA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 4k3g IMMUNOGLOBULIN
LAMBDA VARIABLE
DOMAIN L5(L89S)
(Homo
sapiens) 		5 / 11 THR A 102
THR A  22
THR A  74
ALA A  72
SER A   9
 None
 1.19A 3mg0N-4k3gA:
undetectable		 3mg0N-4k3gA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLJ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4k3g IMMUNOGLOBULIN
LAMBDA VARIABLE
DOMAIN L5(L89S)
(Homo
sapiens) 		4 / 7 VAL A 106
ARG A  61
VAL A  19
GLU A  83
 None
 1.24A 3nljA-4k3gA:
undetectable
3nljB-4k3gA:
undetectable		 3nljA-4k3gA:
14.86
3nljB-4k3gA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4k3g IMMUNOGLOBULIN
LAMBDA VARIABLE
DOMAIN L5(L89S)
(Homo
sapiens) 		4 / 7 VAL A 106
ARG A  61
VAL A  19
GLU A  83
 None
 1.25A 3nlpA-4k3gA:
undetectable
3nlpB-4k3gA:
undetectable		 3nlpA-4k3gA:
14.86
3nlpB-4k3gA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4k3g IMMUNOGLOBULIN
LAMBDA VARIABLE
DOMAIN L5(L89S)
(Homo
sapiens) 		4 / 7 VAL A 106
ARG A  61
VAL A  19
GLU A  83
 None
 1.26A 3nlrA-4k3gA:
undetectable
3nlrB-4k3gA:
undetectable		 3nlrA-4k3gA:
14.86
3nlrB-4k3gA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_1
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 4k3g IMMUNOGLOBULIN
LAMBDA VARIABLE
DOMAIN L5(L89S)
(Homo
sapiens) 		5 / 12 THR A 105
VAL A 106
GLN A 103
GLU A  85
ILE A  75
 None
 1.48A 4s0vA-4k3gA:
undetectable		 4s0vA-4k3gA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADD_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4k3g IMMUNOGLOBULIN
LAMBDA VARIABLE
DOMAIN L5(L89S)
(Homo
sapiens) 		4 / 7 GLU A  83
VAL A 106
ARG A  61
VAL A  19
 None
 1.25A 5addA-4k3gA:
undetectable
5addB-4k3gA:
undetectable		 5addA-4k3gA:
14.86
5addB-4k3gA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		 4k3g IMMUNOGLOBULIN
LAMBDA VARIABLE
DOMAIN L5(L89S)
(Homo
sapiens) 		5 / 12 THR A 102
THR A  22
THR A  74
ALA A  72
SER A   9
 None
 1.19A 5lf7V-4k3gA:
2.7
5lf7b-4k3gA:
undetectable		 5lf7V-4k3gA:
21.43
5lf7b-4k3gA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_N_6V8N305_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		 4k3g IMMUNOGLOBULIN
LAMBDA VARIABLE
DOMAIN L5(L89S)
(Homo
sapiens) 		5 / 12 THR A 102
THR A  22
THR A  74
ALA A  72
SER A   9
 None
 1.19A 5lf7H-4k3gA:
2.8
5lf7N-4k3gA:
undetectable		 5lf7H-4k3gA:
21.43
5lf7N-4k3gA:
20.00