SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4k3j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_1
(PROTEIN (ADENOSINE
KINASE))		 4k3j HEPATOCYTE GROWTH
FACTOR
(Homo
sapiens) 		5 / 12 LEU A 565
GLY A 520
GLY A 521
ALA A 546
LEU A 548
 None
 0.95A 1bx4A-4k3jA:
undetectable		 1bx4A-4k3jA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D8C_A_SORA4000_0
(MALATE SYNTHASE G)		 4k3j HEPATOCYTE GROWTH
FACTOR BETA CHAIN
(Homo
sapiens) 		3 / 3 GLN B 464
HIS B 476
PRO B 475
 None
 0.95A 1d8cA-4k3jB:
undetectable		 1d8cA-4k3jB:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		 4k3j HEPATOCYTE GROWTH
FACTOR BETA CHAIN
(Homo
sapiens) 		4 / 4 SER B 443
VAL B 345
PHE B 462
VAL B 504
 None
 1.14A 1o86A-4k3jB:
undetectable		 1o86A-4k3jB:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_B_SAMB2401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 4k3j HEPATOCYTE GROWTH
FACTOR BETA CHAIN
(Homo
sapiens) 		5 / 12 ARG B 521
LEU B 481
GLY B 517
GLY B 519
ILE B 513
 None
 1.03A 1p91B-4k3jB:
undetectable		 1p91B-4k3jB:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_0
(SUN PROTEIN)		 4k3j HEPATOCYTE GROWTH
FACTOR
(Homo
sapiens) 		5 / 12 GLY A 675
GLY A 674
ASP A 552
GLY A 555
ARG A 556
 None
 1.01A 1sqfA-4k3jA:
undetectable		 1sqfA-4k3jA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4k3j HEPATOCYTE GROWTH
FACTOR
HEPATOCYTE GROWTH
FACTOR BETA CHAIN
(Homo
sapiens) 		4 / 5 ASP B 123
GLY A 696
VAL B 188
ILE B 193
 None
 0.88A 2aoiA-4k3jB:
undetectable		 2aoiA-4k3jB:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EFJ_A_37TA502_1
(3,7-DIMETHYLXANTHINE
METHYLTRANSFERASE)		 4k3j HEPATOCYTE GROWTH
FACTOR BETA CHAIN
(Homo
sapiens) 		5 / 12 LEU B 238
ILE B 247
ILE B 279
ILE B 235
TYR B 291
 None
 1.46A 2efjA-4k3jB:
undetectable		 2efjA-4k3jB:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_1
(VITAMIN D RECEPTOR)		 4k3j HEPATOCYTE GROWTH
FACTOR BETA CHAIN
(Homo
sapiens) 		5 / 12 LEU B 438
VAL B 437
SER B 360
VAL B 486
LEU B 480
 None
 1.35A 2hc4A-4k3jB:
undetectable		 2hc4A-4k3jB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_D_SAMD300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4k3j HEPATOCYTE GROWTH
FACTOR
(Homo
sapiens) 		6 / 12 GLY A 618
GLY A 521
GLY A 674
GLY A 671
THR A 531
LEU A 530
 None
 1.47A 2oxtD-4k3jA:
undetectable		 2oxtD-4k3jA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		 4k3j HEPATOCYTE GROWTH
FACTOR BETA CHAIN
(Homo
sapiens) 		3 / 3 GLU B 493
HIS B  60
GLU B  75
 None
 0.74A 2x45B-4k3jB:
undetectable		 2x45B-4k3jB:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		 4k3j HEPATOCYTE GROWTH
FACTOR BETA CHAIN
(Homo
sapiens) 		3 / 3 GLU B 493
HIS B  60
GLU B  75
 None
 0.78A 2x45C-4k3jB:
undetectable		 2x45C-4k3jB:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 4k3j HEPATOCYTE GROWTH
FACTOR BETA CHAIN
(Homo
sapiens) 		5 / 12 LEU B 438
VAL B 437
SER B 360
VAL B 486
LEU B 480
 None
 1.33A 2zlcA-4k3jB:
undetectable		 2zlcA-4k3jB:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWE_B_DAHB98_1
(TYROSINASE
MELC)		 4k3j HEPATOCYTE GROWTH
FACTOR BETA CHAIN
(Homo
sapiens) 		5 / 11 HIS B 144
ILE B  70
VAL B 136
SER B 132
PRO B  88
 None
 1.40A 2zweA-4k3jB:
undetectable
2zweB-4k3jB:
undetectable		 2zweA-4k3jB:
19.23
2zweB-4k3jB:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWF_B_DAHB98_1
(TYROSINASE
MELC)		 4k3j HEPATOCYTE GROWTH
FACTOR BETA CHAIN
(Homo
sapiens) 		5 / 11 HIS B 144
ILE B  70
VAL B 136
SER B 132
PRO B  88
 None
 1.38A 2zwfA-4k3jB:
undetectable
2zwfB-4k3jB:
1.5		 2zwfA-4k3jB:
19.23
2zwfB-4k3jB:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWG_B_DAHB98_1
(TYROSINASE
MELC)		 4k3j HEPATOCYTE GROWTH
FACTOR BETA CHAIN
(Homo
sapiens) 		5 / 11 HIS B 144
ILE B  70
VAL B 136
SER B 132
PRO B  88
 None
 1.45A 2zwgA-4k3jB:
undetectable
2zwgB-4k3jB:
1.4		 2zwgA-4k3jB:
19.23
2zwgB-4k3jB:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CO4_A_GCSA401_1
(CHITINASE)		 4k3j HEPATOCYTE GROWTH
FACTOR BETA CHAIN
(Homo
sapiens) 		3 / 3 GLU B  76
HIS B  61
HIS B  60
 None
 0.91A 3co4A-4k3jB:
undetectable		 3co4A-4k3jB:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I45_A_NIOA500_1
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN)		 4k3j HEPATOCYTE GROWTH
FACTOR BETA CHAIN
(Homo
sapiens) 		4 / 8 PHE B 346
LEU B 262
PHE B 365
LEU B 342
 None
 0.97A 3i45A-4k3jB:
undetectable		 3i45A-4k3jB:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_1
(NEURAMINIDASE)		 4k3j HEPATOCYTE GROWTH
FACTOR BETA CHAIN
(Homo
sapiens) 		3 / 3 ASP B 236
ARG B 242
ARG B 217
 None
 0.90A 3k37A-4k3jB:
8.7		 3k37A-4k3jB:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4k3j HEPATOCYTE GROWTH
FACTOR
(Homo
sapiens) 		5 / 12 VAL A 687
ALA A 659
GLY A 675
SER A 522
LEU A 530
 None
 0.92A 3ln1A-4k3jA:
undetectable		 3ln1A-4k3jA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4k3j HEPATOCYTE GROWTH
FACTOR
(Homo
sapiens) 		5 / 12 VAL A 687
ALA A 659
GLY A 675
SER A 522
LEU A 530
 None
 0.93A 3ln1B-4k3jA:
undetectable		 3ln1B-4k3jA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4k3j HEPATOCYTE GROWTH
FACTOR
(Homo
sapiens) 		5 / 12 VAL A 687
ALA A 659
GLY A 675
SER A 522
LEU A 530
 None
 0.92A 3ln1C-4k3jA:
undetectable		 3ln1C-4k3jA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4k3j HEPATOCYTE GROWTH
FACTOR BETA CHAIN
(Homo
sapiens) 		5 / 12 PHE B 434
ILE B 442
LEU B 455
ASP B 428
VAL B 465
 None
 1.07A 3rukA-4k3jB:
undetectable		 3rukA-4k3jB:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UY4_A_PAUA302_0
(PANTOTHENATE
SYNTHETASE)		 4k3j HEPATOCYTE GROWTH
FACTOR
HEPATOCYTE GROWTH
FACTOR BETA CHAIN
(Homo
sapiens;
Homo
sapiens) 		4 / 8 VAL A 692
VAL A 690
ASP B 190
GLN A 534
 None
 1.14A 3uy4A-4k3jA:
undetectable		 3uy4A-4k3jA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J03_A_FVSA603_1
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 4k3j HEPATOCYTE GROWTH
FACTOR BETA CHAIN
(Homo
sapiens) 		5 / 12 PHE B 258
TYR B 260
PHE B 253
LEU B 296
LEU B 262
 None
 1.31A 4j03A-4k3jB:
undetectable		 4j03A-4k3jB:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4k3j HEPATOCYTE GROWTH
FACTOR BETA CHAIN
(Homo
sapiens) 		4 / 8 HIS B 150
PRO B 147
ASP B 153
SER B 156
 None
 1.02A 4k0bB-4k3jB:
undetectable		 4k0bB-4k3jB:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_1
(ADENOSINE KINASE)		 4k3j HEPATOCYTE GROWTH
FACTOR
(Homo
sapiens) 		5 / 12 LEU A 565
GLY A 520
GLY A 521
ALA A 546
LEU A 548
 None
 0.90A 4n09C-4k3jA:
undetectable		 4n09C-4k3jA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 4k3j HEPATOCYTE GROWTH
FACTOR BETA CHAIN
(Homo
sapiens) 		5 / 12 LEU B 386
THR B 263
HIS B 388
GLN B 265
ILE B 279
 None
 1.10A 4rp8C-4k3jB:
undetectable		 4rp8C-4k3jB:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_D_ACTD403_0
(PROTON-GATED ION
CHANNEL)		 4k3j HEPATOCYTE GROWTH
FACTOR BETA CHAIN
(Homo
sapiens) 		4 / 4 ILE B 235
ARG B 277
TYR B 291
GLU B 293
 None
 1.37A 4zzbD-4k3jB:
undetectable		 4zzbD-4k3jB:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4k3j HEPATOCYTE GROWTH
FACTOR BETA CHAIN
(Homo
sapiens) 		4 / 7 ILE B  56
PHE B 261
PHE B 253
PHE B 196
 None
 1.02A 5hieA-4k3jB:
undetectable		 5hieA-4k3jB:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4k3j HEPATOCYTE GROWTH
FACTOR
(Homo
sapiens) 		5 / 12 VAL A 687
ALA A 659
GLY A 675
SER A 522
LEU A 530
 None
 0.90A 5jw1A-4k3jA:
undetectable		 5jw1A-4k3jA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_1
(ADENOSINE KINASE)		 4k3j HEPATOCYTE GROWTH
FACTOR
(Homo
sapiens) 		5 / 12 LEU A 565
GLY A 520
GLY A 521
ALA A 546
LEU A 548
 None
 0.84A 5kb5A-4k3jA:
undetectable		 5kb5A-4k3jA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4k3j HEPATOCYTE GROWTH
FACTOR
(Homo
sapiens) 		5 / 12 VAL A 687
ALA A 659
GLY A 675
SER A 522
LEU A 530
 None
 0.89A 5kirA-4k3jA:
undetectable		 5kirA-4k3jA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4k3j HEPATOCYTE GROWTH
FACTOR
(Homo
sapiens) 		5 / 12 VAL A 687
ALA A 659
GLY A 675
SER A 522
LEU A 530
 None
 0.90A 5kirB-4k3jA:
undetectable		 5kirB-4k3jA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODH_G_ACTG710_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 4k3j HEPATOCYTE GROWTH
FACTOR BETA CHAIN
(Homo
sapiens) 		4 / 4 ARG B 277
ILE B 279
TYR B 291
ILE B 235
 None
 1.48A 5odhG-4k3jB:
undetectable		 5odhG-4k3jB:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4k3j HEPATOCYTE GROWTH
FACTOR BETA CHAIN
(Homo
sapiens) 		5 / 10 ILE B  56
ASN B  54
TYR B 321
ILE B 193
LEU B 219
 None
 1.26A 5vkqA-4k3jB:
undetectable
5vkqB-4k3jB:
undetectable		 5vkqA-4k3jB:
13.92
5vkqB-4k3jB:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7B_B_PA1B204_1
(ACYLOXYACYL
HYDROLASE SMALL
SUBUNIT
ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT)		 4k3j HEPATOCYTE GROWTH
FACTOR BETA CHAIN
(Homo
sapiens) 		3 / 3 GLY B 198
ASN B 199
ARG B 217
 None
 0.72A 5w7bD-4k3jB:
undetectable		 5w7bD-4k3jB:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0F_B_DAHB98_0
(MELC
TYROSINASE)		 4k3j HEPATOCYTE GROWTH
FACTOR BETA CHAIN
(Homo
sapiens) 		5 / 11 HIS B 144
ILE B  70
VAL B 136
SER B 132
PRO B  88
 None
 1.49A 5z0fA-4k3jB:
undetectable
5z0fB-4k3jB:
undetectable		 5z0fA-4k3jB:
10.29
5z0fB-4k3jB:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0G_B_DAHB98_0
(MELC
TYROSINASE)		 4k3j HEPATOCYTE GROWTH
FACTOR BETA CHAIN
(Homo
sapiens) 		5 / 11 HIS B 144
ILE B  70
VAL B 136
SER B 132
PRO B  88
 None
 1.45A 5z0gA-4k3jB:
undetectable
5z0gB-4k3jB:
undetectable		 5z0gA-4k3jB:
10.29
5z0gB-4k3jB:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0H_B_DAHB98_0
(MELC
TYROSINASE)		 4k3j HEPATOCYTE GROWTH
FACTOR BETA CHAIN
(Homo
sapiens) 		5 / 11 HIS B 144
ILE B  70
VAL B 136
SER B 132
PRO B  88
 None
 1.46A 5z0hA-4k3jB:
undetectable
5z0hB-4k3jB:
1.5		 5z0hA-4k3jB:
10.29
5z0hB-4k3jB:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0I_B_DAHB98_0
(MELC
TYROSINASE)		 4k3j HEPATOCYTE GROWTH
FACTOR BETA CHAIN
(Homo
sapiens) 		5 / 11 HIS B 144
ILE B  70
VAL B 136
SER B 132
PRO B  88
 None
 1.45A 5z0iA-4k3jB:
undetectable
5z0iB-4k3jB:
1.7		 5z0iA-4k3jB:
10.29
5z0iB-4k3jB:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0J_B_DAHB98_0
(MELC
TYROSINASE)		 4k3j HEPATOCYTE GROWTH
FACTOR BETA CHAIN
(Homo
sapiens) 		5 / 11 HIS B 144
ILE B  70
VAL B 136
SER B 132
PRO B  88
 None
 1.43A 5z0jA-4k3jB:
undetectable
5z0jB-4k3jB:
undetectable		 5z0jA-4k3jB:
10.29
5z0jB-4k3jB:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0K_B_DAHB98_0
(MELC
TYROSINASE)		 4k3j HEPATOCYTE GROWTH
FACTOR BETA CHAIN
(Homo
sapiens) 		5 / 11 HIS B 144
ILE B  70
VAL B 136
SER B 132
PRO B  88
 None
 1.39A 5z0kA-4k3jB:
undetectable
5z0kB-4k3jB:
undetectable		 5z0kA-4k3jB:
10.29
5z0kB-4k3jB:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0L_B_DAHB98_0
(MELC
TYROSINASE)		 4k3j HEPATOCYTE GROWTH
FACTOR BETA CHAIN
(Homo
sapiens) 		5 / 11 HIS B 144
ILE B  70
VAL B 136
SER B 132
PRO B  88
 None
 1.43A 5z0lA-4k3jB:
undetectable
5z0lB-4k3jB:
undetectable		 5z0lA-4k3jB:
10.29
5z0lB-4k3jB:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0M_B_DAHB98_0
(MELC
TYROSINASE)		 4k3j HEPATOCYTE GROWTH
FACTOR BETA CHAIN
(Homo
sapiens) 		5 / 11 HIS B 144
ILE B  70
VAL B 136
SER B 132
PRO B  88
 None
 1.47A 5z0mA-4k3jB:
undetectable
5z0mB-4k3jB:
0.0		 5z0mA-4k3jB:
10.10
5z0mB-4k3jB:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_1
(RIFAMPIN
MONOOXYGENASE)		 4k3j HEPATOCYTE GROWTH
FACTOR
HEPATOCYTE GROWTH
FACTOR BETA CHAIN
(Homo
sapiens) 		5 / 12 HIS A 517
GLY B 225
MET B 227
ARG B 218
GLY A 618
 None
 1.08A 6brdB-4k3jA:
undetectable		 6brdB-4k3jA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 4k3j HEPATOCYTE GROWTH
FACTOR
HEPATOCYTE GROWTH
FACTOR BETA CHAIN
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ARG A 630
LYS A 495
ARG B 143
 None
 1.33A 6c06D-4k3jA:
undetectable		 6c06D-4k3jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_C_PCFC607_0
(CYTOCHROME B)		 4k3j HEPATOCYTE GROWTH
FACTOR BETA CHAIN
(Homo
sapiens) 		5 / 10 ALA B  82
TYR B  71
TYR B  69
THR B  50
PHE B  46
 None
 1.49A 6hu9C-4k3jB:
undetectable		 6hu9C-4k3jB:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_N_PCFN606_0
(CYTOCHROME B)		 4k3j HEPATOCYTE GROWTH
FACTOR BETA CHAIN
(Homo
sapiens) 		5 / 12 ALA B  82
TYR B  71
TYR B  69
THR B  50
PHE B  46
 None
 1.46A 6hu9N-4k3jB:
undetectable		 6hu9N-4k3jB:
20.88