SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4k3w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4k3w ENOYL-COA
HYDRATASE/ISOMERASE
(Marinobacter
hydrocarbonoclas
ticus) 		3 / 3 SER A 195
GLU A 196
GLU A 197
 None
 0.49A 1eqbD-4k3wA:
undetectable		 1eqbD-4k3wA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4k3w ENOYL-COA
HYDRATASE/ISOMERASE
(Marinobacter
hydrocarbonoclas
ticus) 		3 / 3 SER A 195
GLU A 196
GLU A 197
 None
 0.49A 1eqbB-4k3wA:
undetectable		 1eqbB-4k3wA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_1
(HIV-1 PROTEASE)		 4k3w ENOYL-COA
HYDRATASE/ISOMERASE
(Marinobacter
hydrocarbonoclas
ticus) 		5 / 12 GLY A 117
ALA A 139
ASP A 179
ILE A 178
GLY A 142
 None
 1.02A 2b7zA-4k3wA:
undetectable		 2b7zA-4k3wA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_2
(HIV-1 PROTEASE)		 4k3w ENOYL-COA
HYDRATASE/ISOMERASE
(Marinobacter
hydrocarbonoclas
ticus) 		5 / 12 GLY A 117
ALA A 139
ASP A 179
ILE A 178
GLY A 142
 None
 1.03A 2b7zB-4k3wA:
undetectable		 2b7zB-4k3wA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2001_1
(SERUM ALBUMIN)		 4k3w ENOYL-COA
HYDRATASE/ISOMERASE
(Marinobacter
hydrocarbonoclas
ticus) 		5 / 12 LEU A  10
ILE A  23
GLY A 123
CYH A  66
LEU A  58
 None
 0.99A 2bxeB-4k3wA:
2.5		 2bxeB-4k3wA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDX_A_RITA100_1
(PROTEASE)		 4k3w ENOYL-COA
HYDRATASE/ISOMERASE
(Marinobacter
hydrocarbonoclas
ticus) 		5 / 12 GLY A 117
ALA A 139
ASP A 179
ILE A 178
GLY A 142
 None
 1.03A 3ndxA-4k3wA:
undetectable		 3ndxA-4k3wA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 4k3w ENOYL-COA
HYDRATASE/ISOMERASE
(Marinobacter
hydrocarbonoclas
ticus) 		4 / 5 VAL A  20
THR A  22
LEU A 207
LEU A 132
 None
 0.66A 6bqgA-4k3wA:
undetectable		 6bqgA-4k3wA:
15.31