SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4k3x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_A_SAMA1500_0
(ASPARTOKINASE)		 4k3x HEMAGGLUTININ HA1
(Influenza
A
virus) 		4 / 8 ILE A  87
SER A 113
LEU A  66
GLU A  89
 None
 0.92A 2cdqA-4k3xA:
undetectable		 2cdqA-4k3xA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_B_ADNB2005_1
(TRYPTOPHAN
HALOGENASE)		 4k3x HEMAGGLUTININ HA1
(Influenza
A
virus) 		4 / 7 GLY A 249
GLY A 200
VAL A 130
LEU A 164
 None
 0.72A 2oa1B-4k3xA:
undetectable		 2oa1B-4k3xA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_E_P77E203_1
(PROTEIN S100-A4)		 4k3x HEMAGGLUTININ HA1
HEMAGGLUTININ HA2
(Influenza
A
virus) 		4 / 8 SER B  65
SER A 113
LEU A 108
ASP A 107
 None
 0.95A 3m0wE-4k3xB:
0.8
3m0wF-4k3xB:
0.9
3m0wG-4k3xB:
undetectable
3m0wH-4k3xB:
undetectable		 3m0wE-4k3xB:
22.29
3m0wF-4k3xB:
22.29
3m0wG-4k3xB:
22.29
3m0wH-4k3xB:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4k3x HEMAGGLUTININ HA1
(Influenza
A
virus) 		3 / 3 LYS A  56
GLU A  83
TRP A  84
 None
 1.04A 3v4tH-4k3xA:
undetectable		 3v4tH-4k3xA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4k3x HEMAGGLUTININ HA1
(Influenza
A
virus) 		4 / 4 LEU A 177
TYR A 148
PRO A 254
ILE A 123
 None
 1.34A 5esgA-4k3xA:
undetectable		 5esgA-4k3xA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_A_AG2A501_1
(ARGININE/AGMATINE
ANTIPORTER)		 4k3x HEMAGGLUTININ HA1
HEMAGGLUTININ HA2
(Influenza
A
virus) 		4 / 6 GLY B 136
ASN B 135
MET B 133
ILE A  13
 None
 1.03A 5j4nA-4k3xB:
undetectable		 5j4nA-4k3xB:
14.60