SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4k3y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_1
(FATTY ACID-BINDING
PROTEIN)		 4k3y NEURAMINIDASE
(Influenza
A
virus) 		3 / 3 TYR A 247
ARG A 406
GLN A 119
 None
 0.81A 1tw4A-4k3yA:
undetectable		 1tw4A-4k3yA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBL_A_CAMA517_0
(CYTOCHROME P450-CAM)		 4k3y NEURAMINIDASE
(Influenza
A
virus) 		4 / 7 PHE A 121
LEU A 192
VAL A 191
THR A 190
 None
 0.97A 2qblA-4k3yA:
undetectable		 2qblA-4k3yA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_2
(ADENOSINE KINASE,
PUTATIVE)		 4k3y NEURAMINIDASE
(Influenza
A
virus) 		4 / 5 LEU A 319
GLY A 320
MET A 353
PHE A 384
 None
 1.23A 3uq6B-4k3yA:
undetectable		 3uq6B-4k3yA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4k3y NEURAMINIDASE
(Influenza
A
virus) 		3 / 3 LYS A 127
GLU A 128
TRP A 189
 None
 1.36A 3v4tH-4k3yA:
undetectable		 3v4tH-4k3yA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4k3y NEURAMINIDASE
(Influenza
A
virus) 		3 / 3 LYS A 172
GLU A 174
TRP A 189
 None
 1.46A 3v4tH-4k3yA:
undetectable		 3v4tH-4k3yA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 4k3y NEURAMINIDASE
(Influenza
A
virus) 		4 / 4 LEU A 319
GLY A 320
MET A 353
PHE A 384
 None
 1.26A 3vaqB-4k3yA:
undetectable		 3vaqB-4k3yA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4k3y NEURAMINIDASE
(Influenza
A
virus) 		5 / 11 GLN A 226
THR A 239
ARG A 406
PHE A 277
GLY A 291
 None
 1.17A 3wg7A-4k3yA:
undetectable
3wg7B-4k3yA:
undetectable
3wg7T-4k3yA:
undetectable		 3wg7A-4k3yA:
21.72
3wg7B-4k3yA:
20.77
3wg7T-4k3yA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4k3y NEURAMINIDASE
(Influenza
A
virus) 		5 / 11 GLN A 226
THR A 239
ARG A 406
PHE A 277
GLY A 291
 None
 1.23A 3x2qA-4k3yA:
undetectable
3x2qB-4k3yA:
undetectable
3x2qT-4k3yA:
undetectable		 3x2qA-4k3yA:
21.72
3x2qB-4k3yA:
20.77
3x2qT-4k3yA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4k3y NEURAMINIDASE
(Influenza
A
virus) 		4 / 6 SER A 407
ILE A 424
THR A 279
PHE A 352
 None
 1.02A 4acbC-4k3yA:
undetectable		 4acbC-4k3yA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_1
(CYTOCHROME P450 2D6)		 4k3y NEURAMINIDASE
(Influenza
A
virus) 		5 / 12 LEU A 254
LEU A 192
GLN A 226
ALA A 242
VAL A 203
 None
 1.07A 4wnwB-4k3yA:
undetectable		 4wnwB-4k3yA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4k3y NEURAMINIDASE
(Influenza
A
virus) 		5 / 11 GLN A 226
THR A 239
ARG A 406
PHE A 277
GLY A 291
 None
 1.23A 5b1aA-4k3yA:
undetectable
5b1aB-4k3yA:
undetectable
5b1aT-4k3yA:
undetectable		 5b1aA-4k3yA:
21.72
5b1aB-4k3yA:
20.77
5b1aT-4k3yA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_B_CHDB304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4k3y NEURAMINIDASE
(Influenza
A
virus) 		5 / 11 GLN A 226
THR A 239
ARG A 406
PHE A 277
GLY A 291
 None
 1.26A 5b3sA-4k3yA:
undetectable
5b3sB-4k3yA:
undetectable
5b3sT-4k3yA:
undetectable		 5b3sA-4k3yA:
21.72
5b3sB-4k3yA:
20.77
5b3sT-4k3yA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 4k3y NEURAMINIDASE
(Influenza
A
virus) 		3 / 3 TRP A 178
MET A 156
ASN A 157
 None
 1.49A 5uc1B-4k3yA:
undetectable		 5uc1B-4k3yA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		 4k3y NEURAMINIDASE
(Influenza
A
virus) 		3 / 3 TRP A 178
MET A 156
ASN A 157
 None
 1.48A 5uc1A-4k3yA:
undetectable		 5uc1A-4k3yA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7B_B_PA1B204_1
(ACYLOXYACYL
HYDROLASE SMALL
SUBUNIT
ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT)		 4k3y NEURAMINIDASE
(Influenza
A
virus) 		3 / 3 GLY A 369
ASN A 367
ARG A 327
 None
 0.74A 5w7bD-4k3yA:
undetectable		 5w7bD-4k3yA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_B_CHDB304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4k3y NEURAMINIDASE
(Influenza
A
virus) 		5 / 11 GLN A 226
THR A 239
ARG A 406
PHE A 277
GLY A 291
 None
 1.25A 5xdqA-4k3yA:
undetectable
5xdqB-4k3yA:
undetectable
5xdqT-4k3yA:
undetectable		 5xdqA-4k3yA:
21.72
5xdqB-4k3yA:
20.77
5xdqT-4k3yA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4k3y NEURAMINIDASE
(Influenza
A
virus) 		5 / 11 GLN A 226
THR A 239
ARG A 406
PHE A 277
GLY A 291
 None
 1.29A 5xdxA-4k3yA:
undetectable
5xdxB-4k3yA:
undetectable
5xdxT-4k3yA:
undetectable		 5xdxA-4k3yA:
21.72
5xdxB-4k3yA:
20.77
5xdxT-4k3yA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_B_CHDB301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4k3y NEURAMINIDASE
(Influenza
A
virus) 		5 / 11 GLN A 226
THR A 239
ARG A 406
PHE A 277
GLY A 291
 None
 1.17A 5z84A-4k3yA:
undetectable
5z84B-4k3yA:
undetectable
5z84T-4k3yA:
undetectable		 5z84A-4k3yA:
21.72
5z84B-4k3yA:
20.77
5z84T-4k3yA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4k3y NEURAMINIDASE
(Influenza
A
virus) 		5 / 11 GLN A 226
THR A 239
ARG A 406
PHE A 277
GLY A 291
 None
 1.25A 5z86A-4k3yA:
undetectable
5z86B-4k3yA:
undetectable
5z86T-4k3yA:
undetectable		 5z86A-4k3yA:
21.72
5z86B-4k3yA:
20.77
5z86T-4k3yA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4k3y NEURAMINIDASE
(Influenza
A
virus) 		5 / 11 GLN A 226
THR A 239
ARG A 406
PHE A 277
GLY A 291
 None
 1.22A 5zcoA-4k3yA:
undetectable
5zcoB-4k3yA:
undetectable
5zcoT-4k3yA:
undetectable		 5zcoA-4k3yA:
21.72
5zcoB-4k3yA:
20.77
5zcoT-4k3yA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_B_CHDB301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4k3y NEURAMINIDASE
(Influenza
A
virus) 		5 / 11 GLN A 226
THR A 239
ARG A 406
PHE A 277
GLY A 291
 None
 1.21A 5zcpA-4k3yA:
undetectable
5zcpB-4k3yA:
undetectable
5zcpT-4k3yA:
undetectable		 5zcpA-4k3yA:
21.72
5zcpB-4k3yA:
20.77
5zcpT-4k3yA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_B_CHDB301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4k3y NEURAMINIDASE
(Influenza
A
virus) 		5 / 11 GLN A 226
THR A 239
ARG A 406
PHE A 277
GLY A 291
 None
 1.23A 5zcqA-4k3yA:
undetectable
5zcqB-4k3yA:
undetectable
5zcqT-4k3yA:
undetectable		 5zcqA-4k3yA:
21.72
5zcqB-4k3yA:
20.77
5zcqT-4k3yA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4k3y NEURAMINIDASE
(Influenza
A
virus) 		5 / 9 LEU A 397
SER A 402
ILE A 404
PHE A 446
ILE A 444
 None
 1.27A 6ebpA-4k3yA:
undetectable		 6ebpA-4k3yA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4k3y NEURAMINIDASE
(Influenza
A
virus) 		5 / 10 PHE A 374
LEU A 397
ILE A 404
PHE A 446
ILE A 444
 None
 1.07A 6ebpB-4k3yA:
undetectable		 6ebpB-4k3yA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4k3y NEURAMINIDASE
(Influenza
A
virus) 		5 / 10 PHE A 374
LEU A 397
ILE A 404
PHE A 446
ILE A 444
 None
 1.09A 6ebpC-4k3yA:
undetectable		 6ebpC-4k3yA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4k3y NEURAMINIDASE
(Influenza
A
virus) 		5 / 11 PHE A 374
LEU A 397
ILE A 404
PHE A 446
ILE A 444
 None
 1.07A 6ebzA-4k3yA:
undetectable		 6ebzA-4k3yA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4k3y NEURAMINIDASE
(Influenza
A
virus) 		5 / 11 PHE A 374
LEU A 397
ILE A 404
PHE A 446
ILE A 444
 None
 1.07A 6ebzB-4k3yA:
undetectable		 6ebzB-4k3yA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4k3y NEURAMINIDASE
(Influenza
A
virus) 		6 / 11 PHE A 374
LEU A 397
SER A 402
ILE A 404
PHE A 446
ILE A 444
 None
 1.23A 6ebzC-4k3yA:
undetectable		 6ebzC-4k3yA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4k3y NEURAMINIDASE
(Influenza
A
virus) 		5 / 11 PHE A 374
LEU A 397
ILE A 404
PHE A 446
ILE A 444
 None
 1.06A 6ebzD-4k3yA:
undetectable		 6ebzD-4k3yA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		 4k3y NEURAMINIDASE
(Influenza
A
virus) 		4 / 8 GLY A 351
GLN A 350
THR A 279
PHE A 374
 None
 1.12A 6eqpA-4k3yA:
undetectable		 6eqpA-4k3yA:
10.66