SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4k3z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_1
(VP39)		 4k3z D-ERYTHRULOSE
4-PHOSPHATE
DEHYDROGENASE
(Brucella
melitensis) 		3 / 3 ASP A  34
ARG A  68
ASP A 302
 None
 0.87A 1vptA-4k3zA:
undetectable		 1vptA-4k3zA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7K_A_TESA304_1
(ANDROGEN RECEPTOR)		 4k3z D-ERYTHRULOSE
4-PHOSPHATE
DEHYDROGENASE
(Brucella
melitensis) 		5 / 12 ASN A  10
LEU A 274
VAL A  26
LEU A  35
THR A  38
 None
 1.41A 2q7kA-4k3zA:
undetectable		 2q7kA-4k3zA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSK_A_ACTA901_0
(PYRANOSE 2-OXIDASE)		 4k3z D-ERYTHRULOSE
4-PHOSPHATE
DEHYDROGENASE
(Brucella
melitensis) 		4 / 5 SER A  71
PHE A 158
HIS A 227
ASN A   8
 None
 0.83A 3lskA-4k3zA:
0.0		 3lskA-4k3zA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSK_B_ACTB901_0
(PYRANOSE 2-OXIDASE)		 4k3z D-ERYTHRULOSE
4-PHOSPHATE
DEHYDROGENASE
(Brucella
melitensis) 		4 / 6 SER A  71
PHE A 158
HIS A 227
ASN A   8
 None
 0.88A 3lskB-4k3zA:
undetectable		 3lskB-4k3zA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSK_C_ACTC901_0
(PYRANOSE 2-OXIDASE)		 4k3z D-ERYTHRULOSE
4-PHOSPHATE
DEHYDROGENASE
(Brucella
melitensis) 		4 / 5 SER A  71
PHE A 158
HIS A 227
ASN A   8
 None
 0.88A 3lskC-4k3zA:
0.0		 3lskC-4k3zA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSK_D_ACTD901_0
(PYRANOSE 2-OXIDASE)		 4k3z D-ERYTHRULOSE
4-PHOSPHATE
DEHYDROGENASE
(Brucella
melitensis) 		4 / 6 SER A  71
PHE A 158
HIS A 227
ASN A   8
 None
 0.89A 3lskD-4k3zA:
undetectable		 3lskD-4k3zA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEL_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 4k3z D-ERYTHRULOSE
4-PHOSPHATE
DEHYDROGENASE
(Brucella
melitensis) 		4 / 6 ILE A 197
ILE A 119
MET A 162
TRP A 159
 None
 1.46A 3welA-4k3zA:
2.0		 3welA-4k3zA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4k3z D-ERYTHRULOSE
4-PHOSPHATE
DEHYDROGENASE
(Brucella
melitensis) 		5 / 9 THR A  38
ILE A 225
GLU A 269
VAL A 294
ILE A 290
 None
 1.34A 4r38C-4k3zA:
undetectable		 4r38C-4k3zA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4k3z D-ERYTHRULOSE
4-PHOSPHATE
DEHYDROGENASE
(Brucella
melitensis) 		5 / 12 ILE A 270
GLU A 262
ALA A 195
ILE A 251
MET A 233
 None
 1.22A 5ih0A-4k3zA:
undetectable		 5ih0A-4k3zA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8O_B_CHDB1001_0
(GASTROTROPIN)		 4k3z D-ERYTHRULOSE
4-PHOSPHATE
DEHYDROGENASE
(Brucella
melitensis) 		5 / 12 ILE A 105
PHE A 101
LEU A  35
GLN A  36
GLU A 269
 None
 1.44A 5l8oB-4k3zA:
undetectable		 5l8oB-4k3zA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_C_SAMC201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4k3z D-ERYTHRULOSE
4-PHOSPHATE
DEHYDROGENASE
(Brucella
melitensis) 		5 / 12 LEU A   5
ASP A  34
GLY A 304
LEU A 272
VAL A 294
 None
 1.11A 5twjC-4k3zA:
undetectable		 5twjC-4k3zA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_B_BEZB301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 4k3z D-ERYTHRULOSE
4-PHOSPHATE
DEHYDROGENASE
(Brucella
melitensis) 		4 / 8 ILE A 105
LEU A 108
MET A  58
LEU A  62
 None
 0.91A 5u4sB-4k3zA:
undetectable		 5u4sB-4k3zA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 4k3z D-ERYTHRULOSE
4-PHOSPHATE
DEHYDROGENASE
(Brucella
melitensis) 		3 / 3 ASP A  34
ARG A  68
ASP A 302
 None
 0.87A 5zvgA-4k3zA:
undetectable		 5zvgA-4k3zA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4k3z D-ERYTHRULOSE
4-PHOSPHATE
DEHYDROGENASE
(Brucella
melitensis) 		5 / 5 ILE A 290
LEU A 274
ARG A  31
THR A 303
LEU A   5
 None
 1.49A 6nmpN-4k3zA:
undetectable
6nmpW-4k3zA:
undetectable		 6nmpN-4k3zA:
20.96
6nmpW-4k3zA:
9.04