SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4k46'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RTS_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 4k46 ADENYLATE KINASE
(Photobacterium
profundum) 		4 / 8 PHE A 196
ILE A 107
GLY A   7
PHE A 109
 None
 0.66A 1rtsA-4k46A:
undetectable		 1rtsA-4k46A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2L8M_A_CAMA415_0
(CAMPHOR
5-MONOOXYGENASE)		 4k46 ADENYLATE KINASE
(Photobacterium
profundum) 		5 / 9 TYR A 171
THR A 199
ASP A 113
ILE A 116
VAL A 115
 None
 1.39A 2l8mA-4k46A:
undetectable		 2l8mA-4k46A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RHM_D_BEZD194_0
(PUTATIVE KINASE)		 4k46 ADENYLATE KINASE
(Photobacterium
profundum) 		4 / 5 PRO A   9
ARG A 119
ARG A 123
ASP A 159
 None
ADP  A 301 (-3.6A)
ADP  A 301 (-3.6A)
None
 0.93A 2rhmD-4k46A:
12.0		 2rhmD-4k46A:
26.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4k46 ADENYLATE KINASE
(Photobacterium
profundum) 		4 / 5 LEU A 178
GLN A 174
THR A 175
LEU A  65
 None
 1.18A 3ce6D-4k46A:
2.1		 3ce6D-4k46A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4k46 ADENYLATE KINASE
(Photobacterium
profundum) 		4 / 6 ARG A 119
THR A 199
ALA A   8
ALA A  11
 ADP  A 301 (-3.6A)
None
None
ADP  A 301 (-4.2A)
 1.10A 3ns1C-4k46A:
undetectable		 3ns1C-4k46A:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_A_ADNA303_1
(5'/3'-NUCLEOTIDASE
SURE)		 4k46 ADENYLATE KINASE
(Photobacterium
profundum) 		5 / 10 GLY A   7
ALA A  93
ILE A   4
LEU A   6
TYR A 182
 None
 1.04A 4xj7A-4k46A:
2.8
4xj7B-4k46A:
3.0		 4xj7A-4k46A:
25.53
4xj7B-4k46A:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_X_BEZX801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4k46 ADENYLATE KINASE
(Photobacterium
profundum) 		4 / 5 ARG A  71
ILE A  72
GLY A  80
ILE A  29
 None
 0.89A 5dzki-4k46A:
undetectable
5dzkj-4k46A:
undetectable
5dzkx-4k46A:
undetectable		 5dzki-4k46A:
22.08
5dzkj-4k46A:
22.08
5dzkx-4k46A:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_0
(AMINOACYL-TRNA
SYNTHETASE)		 4k46 ADENYLATE KINASE
(Photobacterium
profundum) 		5 / 12 LEU A 168
SER A 114
GLU A 118
VAL A 117
ARG A 119
 None
None
None
None
ADP  A 301 (-3.6A)
 1.23A 5f9zB-4k46A:
undetectable		 5f9zB-4k46A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_A_D16A401_1
(ORF70)		 4k46 ADENYLATE KINASE
(Photobacterium
profundum) 		4 / 7 PHE A 196
ILE A 107
GLY A   7
PHE A 109
 None
 0.67A 5h3aA-4k46A:
undetectable		 5h3aA-4k46A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4k46 ADENYLATE KINASE
(Photobacterium
profundum) 		5 / 12 ARG A 167
LYS A 160
VAL A 205
GLY A  14
ARG A  36
 AMP  A 302 (-4.2A)
None
None
ADP  A 301 (-3.5A)
AMP  A 302 (-2.5A)
 1.15A 5vooE-4k46A:
undetectable		 5vooE-4k46A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 4k46 ADENYLATE KINASE
(Photobacterium
profundum) 		4 / 7 PHE A 196
ILE A 107
GLY A   7
PHE A 109
 None
 0.69A 5x5qC-4k46A:
undetectable		 5x5qC-4k46A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 4k46 ADENYLATE KINASE
(Photobacterium
profundum) 		4 / 8 PHE A 196
ILE A 107
GLY A   7
PHE A 109
 None
 0.72A 5x5qD-4k46A:
undetectable		 5x5qD-4k46A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_F_D16F402_1
(THYMIDYLATE SYNTHASE)		 4k46 ADENYLATE KINASE
(Photobacterium
profundum) 		4 / 8 PHE A 196
ILE A 107
GLY A   7
PHE A 109
 None
 0.69A 5x5qF-4k46A:
undetectable		 5x5qF-4k46A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_A_MTXA402_1
(THYMIDYLATE SYNTHASE)		 4k46 ADENYLATE KINASE
(Photobacterium
profundum) 		5 / 12 PHE A 196
ILE A 107
GLY A   7
PHE A 109
ALA A 180
 None
 1.09A 5x66A-4k46A:
undetectable
5x66B-4k46A:
undetectable		 5x66A-4k46A:
21.55
5x66B-4k46A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 4k46 ADENYLATE KINASE
(Photobacterium
profundum) 		5 / 10 PHE A 196
ILE A 107
GLY A   7
PHE A 109
ALA A 180
 None
 1.11A 5x66D-4k46A:
undetectable		 5x66D-4k46A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_F_MTXF402_1
(THYMIDYLATE SYNTHASE)		 4k46 ADENYLATE KINASE
(Photobacterium
profundum) 		5 / 12 PHE A 196
ILE A 107
GLY A   7
PHE A 109
ALA A 180
 None
 1.11A 5x66F-4k46A:
undetectable		 5x66F-4k46A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4k46 ADENYLATE KINASE
(Photobacterium
profundum) 		4 / 5 ILE A  20
PHE A  24
ARG A   2
THR A 191
 None
 1.28A 5z84N-4k46A:
undetectable
5z84W-4k46A:
undetectable		 5z84N-4k46A:
17.21
5z84W-4k46A:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_B_HISB402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 4k46 ADENYLATE KINASE
(Photobacterium
profundum) 		5 / 9 VAL A  52
LEU A  67
GLY A  46
LEU A  45
GLN A  48
 None
 1.25A 6czmA-4k46A:
undetectable
6czmB-4k46A:
undetectable		 6czmA-4k46A:
20.79
6czmB-4k46A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_C_HISC402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 4k46 ADENYLATE KINASE
(Photobacterium
profundum) 		5 / 9 VAL A  52
LEU A  67
GLY A  46
LEU A  45
GLN A  48
 None
 1.23A 6czmB-4k46A:
undetectable
6czmC-4k46A:
undetectable		 6czmB-4k46A:
20.79
6czmC-4k46A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_B_SAMB301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 4k46 ADENYLATE KINASE
(Photobacterium
profundum) 		5 / 12 LEU A   5
ILE A 179
ILE A   3
VAL A 103
ILE A 107
 None
 0.95A 6emuB-4k46A:
undetectable		 6emuB-4k46A:
21.40