SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4k48'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_1
(HIV-1 PROTEASE)		 4k48 LEUCINE--TRNA LIGASE
(Streptococcus
pneumoniae) 		6 / 12 GLY A 304
ALA A 325
ASP A 326
PRO A 341
ALA A 339
VAL A 260
 None
 1.35A 2b7zA-4k48A:
2.6		 2b7zA-4k48A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_2
(HIV-1 PROTEASE)		 4k48 LEUCINE--TRNA LIGASE
(Streptococcus
pneumoniae) 		5 / 12 GLY A 304
ALA A 325
ASP A 326
ALA A 339
VAL A 260
 None
 1.00A 2b7zB-4k48A:
2.4		 2b7zB-4k48A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		 4k48 LEUCINE--TRNA LIGASE
(Streptococcus
pneumoniae) 		4 / 7 ILE A 324
TYR A 327
PHE A 350
ASP A 347
 None
 1.08A 2qebA-4k48A:
undetectable		 2qebA-4k48A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		 4k48 LEUCINE--TRNA LIGASE
(Streptococcus
pneumoniae) 		4 / 7 ILE A 324
TYR A 327
PHE A 350
ASP A 347
 None
 1.05A 2qebB-4k48A:
undetectable		 2qebB-4k48A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_C_TOPC200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4k48 LEUCINE--TRNA LIGASE
(Streptococcus
pneumoniae) 		5 / 11 ALA A 256
VAL A 361
ILE A 396
LEU A 384
THR A 257
 None
 1.33A 3fl9C-4k48A:
undetectable		 3fl9C-4k48A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_A_IMNA201_1
(TRANSTHYRETIN)		 4k48 LEUCINE--TRNA LIGASE
(Streptococcus
pneumoniae) 		3 / 3 LYS A 395
LEU A 387
ALA A 394
 None
 0.66A 4ikiA-4k48A:
undetectable		 4ikiA-4k48A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4k48 LEUCINE--TRNA LIGASE
(Streptococcus
pneumoniae) 		5 / 12 ALA A 230
ALA A 392
ILE A 393
ASN A 313
GLY A 406
 None
 1.22A 4r38A-4k48A:
undetectable		 4r38A-4k48A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4k48 LEUCINE--TRNA LIGASE
(Streptococcus
pneumoniae) 		5 / 12 ALA A 230
ALA A 392
ILE A 393
ASN A 313
GLY A 406
 None
 1.23A 4r38D-4k48A:
undetectable		 4r38D-4k48A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_0
(REGULATORY PROTEIN
TETR)		 4k48 LEUCINE--TRNA LIGASE
(Streptococcus
pneumoniae) 		5 / 12 ALA A 309
GLU A 242
LEU A 267
TYR A 327
PHE A 234
 None
 1.49A 5vlmA-4k48A:
undetectable		 5vlmA-4k48A:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_0
(REGULATORY PROTEIN
TETR)		 4k48 LEUCINE--TRNA LIGASE
(Streptococcus
pneumoniae) 		5 / 12 ALA A 309
GLU A 242
LEU A 267
TYR A 327
PHE A 234
 None
 1.46A 5vlmC-4k48A:
undetectable		 5vlmC-4k48A:
23.22