SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4k4d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 4k4d PROOFREADING
THIOESTERASE ENTH
(Escherichia
coli) 		4 / 6 GLY A  96
THR A  46
GLU A 121
GLU A  37
 None
 0.99A 3fpjA-4k4dA:
undetectable		 3fpjA-4k4dA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_H_DHIH3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 4k4d PROOFREADING
THIOESTERASE ENTH
(Escherichia
coli) 		3 / 3 LEU A 105
TRP A 114
GLY A  66
 None
 0.63A 3l35A-4k4dA:
undetectable
3l35H-4k4dA:
undetectable		 3l35A-4k4dA:
12.41
3l35H-4k4dA:
5.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_K_DHIK3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 4k4d PROOFREADING
THIOESTERASE ENTH
(Escherichia
coli) 		3 / 3 LEU A 105
TRP A 114
GLY A  66
 None
 0.64A 3l35B-4k4dA:
undetectable
3l35K-4k4dA:
undetectable		 3l35B-4k4dA:
12.41
3l35K-4k4dA:
5.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_A_IPHA101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4k4d PROOFREADING
THIOESTERASE ENTH
(Escherichia
coli) 		4 / 5 CYH A 126
HIS A  54
LEU A  53
HIS A  89
 None
HFQ  A 201 (-3.2A)
None
HFQ  A 201 (-4.2A)
 1.38A 5hrqA-4k4dA:
undetectable
5hrqB-4k4dA:
undetectable
5hrqF-4k4dA:
undetectable		 5hrqA-4k4dA:
8.70
5hrqB-4k4dA:
14.29
5hrqF-4k4dA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_G_IPHG101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4k4d PROOFREADING
THIOESTERASE ENTH
(Escherichia
coli) 		4 / 6 HIS A  89
CYH A 126
HIS A  54
LEU A  53
 HFQ  A 201 (-4.2A)
None
HFQ  A 201 (-3.2A)
None
 1.37A 5hrqD-4k4dA:
undetectable
5hrqG-4k4dA:
undetectable
5hrqH-4k4dA:
undetectable		 5hrqD-4k4dA:
14.29
5hrqG-4k4dA:
8.70
5hrqH-4k4dA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_K_IPHK101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4k4d PROOFREADING
THIOESTERASE ENTH
(Escherichia
coli) 		4 / 6 HIS A  89
CYH A 126
HIS A  54
LEU A  53
 HFQ  A 201 (-4.2A)
None
HFQ  A 201 (-3.2A)
None
 1.37A 5hrqH-4k4dA:
undetectable
5hrqK-4k4dA:
undetectable
5hrqL-4k4dA:
undetectable		 5hrqH-4k4dA:
14.29
5hrqK-4k4dA:
8.70
5hrqL-4k4dA:
14.29