SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4k4k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4k4k PUTATIVE CELL
ADHESION PROTEIN
(Bacteroides
uniformis) 		5 / 12 ILE A 169
ALA A 224
PHE A 241
ILE A 274
THR A 219
 None
 0.95A 1drbB-4k4kA:
undetectable		 1drbB-4k4kA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4k4k PUTATIVE CELL
ADHESION PROTEIN
(Bacteroides
uniformis) 		5 / 10 ILE A 169
ALA A 224
PHE A 241
ILE A 274
THR A 219
 None
 0.99A 1j3jA-4k4kA:
undetectable		 1j3jA-4k4kA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4k4k PUTATIVE CELL
ADHESION PROTEIN
(Bacteroides
uniformis) 		5 / 12 ALA A 179
GLN A 249
PHE A 251
ILE A 276
ASP A 172
 None
 1.12A 2v95A-4k4kA:
undetectable		 2v95A-4k4kA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_2
(DIHYDROFOLATE
REDUCTASE)		 4k4k PUTATIVE CELL
ADHESION PROTEIN
(Bacteroides
uniformis) 		4 / 4 ILE A 169
PHE A 241
ILE A 274
THR A 219
 None
 0.96A 3ia4A-4k4kA:
undetectable		 3ia4A-4k4kA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_C_C2FC1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 4k4k PUTATIVE CELL
ADHESION PROTEIN
(Bacteroides
uniformis) 		3 / 3 ARG A 105
PRO A 152
PHE A 107
 None
 0.86A 3thrC-4k4kA:
undetectable		 3thrC-4k4kA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4k4k PUTATIVE CELL
ADHESION PROTEIN
(Bacteroides
uniformis) 		5 / 12 ALA A  38
ALA A  58
ILE A  59
GLY A  86
GLN A  81
 None
 0.99A 4r38A-4k4kA:
undetectable		 4r38A-4k4kA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFP_A_8W5A804_2
(GLUCOCORTICOID
RECEPTOR)		 4k4k PUTATIVE CELL
ADHESION PROTEIN
(Bacteroides
uniformis) 		4 / 4 LEU A 229
MET A 237
ILE A 136
LEU A 165
 None
 1.32A 5nfpA-4k4kA:
undetectable		 5nfpA-4k4kA:
19.88