SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4k51'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		 4k51 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A
(Saccharomyces
cerevisiae) 		5 / 11 SER A 369
ILE A 370
ALA A 332
THR A 335
LEU A 297
 None
 1.23A 2v0mD-4k51A:
undetectable		 2v0mD-4k51A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_C_PARC500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 4k51 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A
(Saccharomyces
cerevisiae) 		5 / 10 SER A 369
SER A 375
TYR A 307
GLU A 382
TYR A 388
 None
 1.43A 4qb9C-4k51A:
undetectable		 4qb9C-4k51A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_D_PARD500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 4k51 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A
(Saccharomyces
cerevisiae) 		4 / 8 SER A 369
SER A 375
GLU A 382
TYR A 388
 None
 1.35A 4qb9D-4k51A:
undetectable		 4qb9D-4k51A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_E_CHDE104_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4k51 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 424
GLU A 392
LEU A 387
LEU A 404
LEU A 408
 None
 0.99A 4wg0C-4k51A:
undetectable
4wg0D-4k51A:
undetectable
4wg0E-4k51A:
undetectable		 4wg0C-4k51A:
4.91
4wg0D-4k51A:
4.91
4wg0E-4k51A:
4.91