SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4k5a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_A_SAMA200_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 4k5a DESIGNED ANKYRIN
REPEAT PROTEIN
013_D12
(Escherichia
coli) 		5 / 11 ALA B 137
HIS B 118
GLU B 130
LEU B 126
LEU B 165
 None
 1.20A 1mjlA-4k5aB:
undetectable
1mjlB-4k5aB:
undetectable		 1mjlA-4k5aB:
20.71
1mjlB-4k5aB:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_2
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 4k5a DESIGNED ANKYRIN
REPEAT PROTEIN
013_D12
(Escherichia
coli) 		4 / 6 GLN B 122
ASN B 156
ASN B 107
LEU B 132
 None
 1.23A 2nyrA-4k5aB:
undetectable		 2nyrA-4k5aB:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_E_IPHE101_0
(INSULIN)		 4k5a DESIGNED ANKYRIN
REPEAT PROTEIN
013_D12
(Escherichia
coli) 		5 / 11 ILE B 128
LEU B 117
HIS B 135
LEU B 133
ALA B 137
 None
 1.11A 4p65E-4k5aB:
undetectable
4p65F-4k5aB:
undetectable
4p65J-4k5aB:
undetectable
4p65L-4k5aB:
undetectable		 4p65E-4k5aB:
7.14
4p65F-4k5aB:
11.24
4p65J-4k5aB:
11.24
4p65L-4k5aB:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_I_IPHI101_0
(INSULIN)		 4k5a DESIGNED ANKYRIN
REPEAT PROTEIN
013_D12
(Escherichia
coli) 		5 / 12 VAL B  30
LEU B  18
LEU B  51
ILE B  62
ALA B  71
 None
 1.02A 4p65B-4k5aB:
undetectable
4p65D-4k5aB:
undetectable
4p65I-4k5aB:
undetectable
4p65J-4k5aB:
undetectable		 4p65B-4k5aB:
11.24
4p65D-4k5aB:
11.24
4p65I-4k5aB:
7.14
4p65J-4k5aB:
11.24