SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4k5c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		 4k5c LOOP DESIGNED
ANKYRIN REPEAT
PROTEIN NRAN1_G06_C
(Escherichia
coli) 		4 / 4 ASP A  13
LEU A  18
LEU A  19
LEU A  14
 None
 1.37A 1u18A-4k5cA:
undetectable		 1u18A-4k5cA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA501_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4k5c LOOP DESIGNED
ANKYRIN REPEAT
PROTEIN NRAN1_G06_C
(Escherichia
coli) 		5 / 12 ILE A 142
VAL A  63
ILE A 109
GLU A  64
GLU A  61
 None
 1.30A 4i41A-4k5cA:
undetectable		 4i41A-4k5cA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_I_IPHI101_0
(INSULIN)		 4k5c LOOP DESIGNED
ANKYRIN REPEAT
PROTEIN NRAN1_G06_C
(Escherichia
coli) 		5 / 12 VAL A  30
LEU A  18
LEU A  51
ILE A  62
ALA A  71
 None
 1.02A 4p65B-4k5cA:
undetectable
4p65D-4k5cA:
undetectable
4p65I-4k5cA:
undetectable
4p65J-4k5cA:
undetectable		 4p65B-4k5cA:
10.33
4p65D-4k5cA:
10.33
4p65I-4k5cA:
7.14
4p65J-4k5cA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_I_IPHI101_0
(INSULIN)		 4k5c LOOP DESIGNED
ANKYRIN REPEAT
PROTEIN NRAN1_G06_C
(Escherichia
coli) 		5 / 12 VAL A 110
LEU A  98
LEU A 131
ILE A 142
ALA A 151
 None
 1.01A 4p65B-4k5cA:
undetectable
4p65D-4k5cA:
undetectable
4p65I-4k5cA:
undetectable
4p65J-4k5cA:
undetectable		 4p65B-4k5cA:
10.33
4p65D-4k5cA:
10.33
4p65I-4k5cA:
7.14
4p65J-4k5cA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_K_IPHK101_0
(INSULIN)		 4k5c LOOP DESIGNED
ANKYRIN REPEAT
PROTEIN NRAN1_G06_C
(Escherichia
coli) 		5 / 12 LEU A 131
VAL A 110
LEU A  98
ILE A 142
ALA A 151
 None
 1.05A 4p65F-4k5cA:
undetectable
4p65H-4k5cA:
undetectable
4p65K-4k5cA:
undetectable
4p65L-4k5cA:
undetectable		 4p65F-4k5cA:
10.33
4p65H-4k5cA:
10.33
4p65K-4k5cA:
7.14
4p65L-4k5cA:
10.33