SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4k5r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D8C_A_SORA4000_0
(MALATE SYNTHASE G)		 4k5r OXYGENASE
(Streptomyces
argillaceus) 		3 / 3 GLN A 303
HIS A 297
PRO A 299
 None
None
FAD  A 601 (-4.5A)
 0.94A 1d8cA-4k5rA:
undetectable		 1d8cA-4k5rA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHO_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4k5r OXYGENASE
(Streptomyces
argillaceus) 		5 / 9 GLY A 301
GLY A  92
PHE A  85
LEU A  93
GLY A  82
 None
 1.09A 1jhoA-4k5rA:
undetectable		 1jhoA-4k5rA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHR_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4k5r OXYGENASE
(Streptomyces
argillaceus) 		5 / 9 GLY A 301
GLY A  92
PHE A  85
LEU A  93
GLY A  82
 None
 1.12A 1jhrA-4k5rA:
undetectable		 1jhrA-4k5rA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHY_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4k5r OXYGENASE
(Streptomyces
argillaceus) 		5 / 9 GLY A 301
GLY A  92
PHE A  85
LEU A  93
GLY A  82
 None
 1.07A 1jhyA-4k5rA:
undetectable		 1jhyA-4k5rA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)		 4k5r OXYGENASE
(Streptomyces
argillaceus) 		5 / 12 ALA A  38
GLY A  20
LEU A 319
ALA A 290
LEU A  31
 None
FAD  A 601 ( 4.8A)
None
None
None
 1.24A 1jipA-4k5rA:
undetectable		 1jipA-4k5rA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L4N_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4k5r OXYGENASE
(Streptomyces
argillaceus) 		5 / 9 GLY A 301
GLY A  92
PHE A  85
LEU A  93
GLY A  82
 None
 1.05A 1l4nA-4k5rA:
undetectable		 1l4nA-4k5rA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5K_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4k5r OXYGENASE
(Streptomyces
argillaceus) 		5 / 9 GLY A 301
GLY A  92
PHE A  85
LEU A  93
GLY A  82
 None
 1.07A 1l5kA-4k5rA:
undetectable		 1l5kA-4k5rA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5L_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4k5r OXYGENASE
(Streptomyces
argillaceus) 		5 / 9 GLY A 301
GLY A  92
PHE A  85
LEU A  93
GLY A  82
 None
 1.08A 1l5lA-4k5rA:
undetectable		 1l5lA-4k5rA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5M_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4k5r OXYGENASE
(Streptomyces
argillaceus) 		5 / 9 GLY A 301
GLY A  92
PHE A  85
LEU A  93
GLY A  82
 None
 1.09A 1l5mA-4k5rA:
undetectable		 1l5mA-4k5rA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB503_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4k5r OXYGENASE
(Streptomyces
argillaceus) 		4 / 6 ARG A 358
ALA A 355
TYR A 231
ILE A 300
 None
 1.29A 1oniB-4k5rA:
undetectable
1oniC-4k5rA:
undetectable		 1oniB-4k5rA:
15.08
1oniC-4k5rA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_1
(PHOSPHOLIPASE A2
HOMOLOG 2)		 4k5r OXYGENASE
(Streptomyces
argillaceus) 		5 / 12 LEU A  39
GLY A  19
LEU A 137
GLY A 136
TYR A 155
 None
FAD  A 601 (-3.4A)
None
None
None
 1.04A 1y4lA-4k5rA:
undetectable		 1y4lA-4k5rA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2002_1
(SERUM ALBUMIN)		 4k5r OXYGENASE
(Streptomyces
argillaceus) 		5 / 11 ARG A  32
LEU A  31
LEU A 332
ARG A 324
GLY A 325
 None
 1.36A 2bxmA-4k5rA:
undetectable		 2bxmA-4k5rA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CBR_A_A80A201_1
(PROTEIN (CRABP-I))		 4k5r OXYGENASE
(Streptomyces
argillaceus) 		5 / 12 VAL A 478
LEU A 439
VAL A 463
VAL A 427
GLY A 415
 None
 0.97A 2cbrA-4k5rA:
undetectable		 2cbrA-4k5rA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_B_BRLB2_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 4k5r OXYGENASE
(Streptomyces
argillaceus) 		5 / 12 HIS A 340
TYR A 282
LEU A 289
VAL A 172
LEU A 347
 None
 1.40A 2prgB-4k5rA:
undetectable		 2prgB-4k5rA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 4k5r OXYGENASE
(Streptomyces
argillaceus) 		4 / 6 PHE A  95
GLY A 301
GLY A 302
ASN A 306
 None
None
FAD  A 601 (-3.4A)
FAD  A 601 (-3.6A)
 0.95A 2qr2A-4k5rA:
undetectable
2qr2B-4k5rA:
undetectable		 2qr2A-4k5rA:
20.36
2qr2B-4k5rA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A500_1
(ORF12)		 4k5r OXYGENASE
(Streptomyces
argillaceus) 		5 / 10 VAL A 163
LEU A  31
ARG A  32
GLY A  29
ALA A 121
 None
 1.12A 2xf3A-4k5rA:
undetectable		 2xf3A-4k5rA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_A_J01A500_1
(ORF12)		 4k5r OXYGENASE
(Streptomyces
argillaceus) 		4 / 8 VAL A 163
ARG A  32
GLY A  29
ALA A 121
 None
 0.88A 2xfsA-4k5rA:
undetectable		 2xfsA-4k5rA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1436_1
(ORF12)		 4k5r OXYGENASE
(Streptomyces
argillaceus) 		4 / 8 VAL A 163
ARG A  32
GLY A  29
ALA A 121
 None
 0.87A 2xh9A-4k5rA:
undetectable		 2xh9A-4k5rA:
26.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_2
(BETA-1 ADRENERGIC
RECEPTOR)		 4k5r OXYGENASE
(Streptomyces
argillaceus) 		3 / 3 VAL A 393
ASN A 314
TRP A 317
 None
 0.90A 2y00B-4k5rA:
undetectable		 2y00B-4k5rA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_A_BEZA302_0
(DISULFIDE
INTERCHANGE PROTEIN)		 4k5r OXYGENASE
(Streptomyces
argillaceus) 		4 / 6 PRO A 480
LEU A 331
ALA A 321
PRO A 438
 None
 1.33A 3gv1A-4k5rA:
undetectable
3gv1C-4k5rA:
1.7		 3gv1A-4k5rA:
13.99
3gv1C-4k5rA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZJ_A_ACRA405_1
(ACARBOSE/MALTOSE
BINDING PROTEIN GACH)		 4k5r OXYGENASE
(Streptomyces
argillaceus) 		5 / 12 GLU A 338
GLY A 415
ARG A 479
ALA A 436
GLY A 316
 None
 1.28A 3jzjA-4k5rA:
undetectable		 3jzjA-4k5rA:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROZ_A_NCAA266_0
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 4k5r OXYGENASE
(Streptomyces
argillaceus) 		4 / 6 LEU A 477
ALA A 494
ASP A 448
THR A 453
 None
 1.03A 3rozA-4k5rA:
4.2		 3rozA-4k5rA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOA_A_ACRA1587_2
(TREHALOSE
SYNTHASE/AMYLASE
TRES)		 4k5r OXYGENASE
(Streptomyces
argillaceus) 		3 / 3 ARG A 173
PHE A 180
PRO A 181
 None
 0.85A 3zoaB-4k5rA:
undetectable		 3zoaB-4k5rA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQI_A_NIOA403_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4k5r OXYGENASE
(Streptomyces
argillaceus) 		5 / 9 GLY A 301
GLY A  92
PHE A  85
LEU A  93
GLY A  82
 None
 1.11A 4kqiA-4k5rA:
undetectable		 4kqiA-4k5rA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_A_PAUA301_0
(TYPE III
PANTOTHENATE KINASE)		 4k5r OXYGENASE
(Streptomyces
argillaceus) 		5 / 12 VAL A  18
LEU A 289
GLY A 164
ASP A 166
LEU A 137
 FAD  A 601 ( 4.9A)
None
None
FAD  A 601 (-4.7A)
None
 1.28A 4o5fA-4k5rA:
undetectable
4o5fB-4k5rA:
undetectable		 4o5fA-4k5rA:
22.16
4o5fB-4k5rA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 4k5r OXYGENASE
(Streptomyces
argillaceus) 		5 / 12 LEU A 137
VAL A  18
LEU A 289
GLY A 164
ASP A 166
 None
FAD  A 601 ( 4.9A)
None
None
FAD  A 601 (-4.7A)
 1.27A 4o5fA-4k5rA:
undetectable
4o5fB-4k5rA:
undetectable		 4o5fA-4k5rA:
22.16
4o5fB-4k5rA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4k5r OXYGENASE
(Streptomyces
argillaceus) 		3 / 3 PRO A  84
LEU A  83
GLN A 303
 None
 0.50A 4pevB-4k5rA:
2.1		 4pevB-4k5rA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4k5r OXYGENASE
(Streptomyces
argillaceus) 		5 / 11 ALA A 124
ALA A 121
GLY A  35
GLY A  34
ALA A  33
 None
 0.86A 4qvlK-4k5rA:
undetectable
4qvlL-4k5rA:
undetectable		 4qvlK-4k5rA:
16.89
4qvlL-4k5rA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4k5r OXYGENASE
(Streptomyces
argillaceus) 		5 / 11 ALA A 124
ALA A 121
GLY A  35
GLY A  34
ALA A  33
 None
 0.86A 4qvlY-4k5rA:
undetectable
4qvlZ-4k5rA:
undetectable		 4qvlY-4k5rA:
16.89
4qvlZ-4k5rA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4k5r OXYGENASE
(Streptomyces
argillaceus) 		5 / 9 ALA A 124
ALA A 121
GLY A  35
GLY A  34
ALA A  33
 None
 0.87A 4qvmK-4k5rA:
undetectable
4qvmL-4k5rA:
undetectable		 4qvmK-4k5rA:
17.08
4qvmL-4k5rA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4k5r OXYGENASE
(Streptomyces
argillaceus) 		5 / 10 ALA A 124
ALA A 121
GLY A  35
GLY A  34
ALA A  33
 None
 0.87A 4qvmY-4k5rA:
undetectable
4qvmZ-4k5rA:
undetectable		 4qvmY-4k5rA:
17.08
4qvmZ-4k5rA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4k5r OXYGENASE
(Streptomyces
argillaceus) 		5 / 10 ALA A 124
ALA A 121
GLY A  35
GLY A  34
ALA A  33
 None
 0.88A 4qvpK-4k5rA:
undetectable
4qvpL-4k5rA:
undetectable		 4qvpK-4k5rA:
16.89
4qvpL-4k5rA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4k5r OXYGENASE
(Streptomyces
argillaceus) 		5 / 10 ALA A 124
ALA A 121
GLY A  35
GLY A  34
ALA A  33
 None
 0.88A 4qvpY-4k5rA:
undetectable
4qvpZ-4k5rA:
undetectable		 4qvpY-4k5rA:
16.89
4qvpZ-4k5rA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4k5r OXYGENASE
(Streptomyces
argillaceus) 		5 / 11 ALA A 124
ALA A 121
GLY A  35
GLY A  34
ALA A  33
 None
 0.87A 4qw1K-4k5rA:
undetectable
4qw1L-4k5rA:
undetectable		 4qw1K-4k5rA:
17.08
4qw1L-4k5rA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4k5r OXYGENASE
(Streptomyces
argillaceus) 		5 / 10 ALA A 124
ALA A 121
GLY A  35
GLY A  34
ALA A  33
 None
 0.87A 4qw1Y-4k5rA:
undetectable
4qw1Z-4k5rA:
undetectable		 4qw1Y-4k5rA:
17.08
4qw1Z-4k5rA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4k5r OXYGENASE
(Streptomyces
argillaceus) 		5 / 10 ALA A 124
ALA A 121
GLY A  35
GLY A  34
ALA A  33
 None
 0.87A 4qw3K-4k5rA:
undetectable
4qw3L-4k5rA:
undetectable		 4qw3K-4k5rA:
16.89
4qw3L-4k5rA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4k5r OXYGENASE
(Streptomyces
argillaceus) 		5 / 10 ALA A 124
ALA A 121
GLY A  35
GLY A  34
ALA A  33
 None
 0.86A 4qw3Y-4k5rA:
undetectable
4qw3Z-4k5rA:
undetectable		 4qw3Y-4k5rA:
16.89
4qw3Z-4k5rA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_A_STRA601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 4k5r OXYGENASE
(Streptomyces
argillaceus) 		4 / 6 ALA A 279
GLY A 291
ILE A 178
VAL A 163
 None
FAD  A 601 (-3.5A)
None
None
 0.81A 4r21A-4k5rA:
undetectable		 4r21A-4k5rA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_B_STRB601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 4k5r OXYGENASE
(Streptomyces
argillaceus) 		5 / 9 ALA A 279
GLY A 291
ALA A 293
ILE A 178
VAL A 163
 None
FAD  A 601 (-3.5A)
None
None
None
 1.06A 4r21B-4k5rA:
undetectable		 4r21B-4k5rA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XNX_A_41XA707_1
(TRANSPORTER)		 4k5r OXYGENASE
(Streptomyces
argillaceus) 		5 / 11 ALA A 162
VAL A  16
GLY A 136
VAL A 172
GLY A 164
 None
 1.19A 4xnxA-4k5rA:
undetectable		 4xnxA-4k5rA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_A_PAUA302_0
(TYPE III
PANTOTHENATE KINASE)		 4k5r OXYGENASE
(Streptomyces
argillaceus) 		5 / 12 VAL A  18
LEU A 289
GLY A 164
ASP A 166
LEU A 137
 FAD  A 601 ( 4.9A)
None
None
FAD  A 601 (-4.7A)
None
 1.26A 5b8hA-4k5rA:
undetectable
5b8hB-4k5rA:
undetectable		 5b8hA-4k5rA:
23.62
5b8hB-4k5rA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 4k5r OXYGENASE
(Streptomyces
argillaceus) 		5 / 12 LEU A 137
VAL A  18
LEU A 289
GLY A 164
ASP A 166
 None
FAD  A 601 ( 4.9A)
None
None
FAD  A 601 (-4.7A)
 1.25A 5b8hA-4k5rA:
undetectable
5b8hB-4k5rA:
undetectable		 5b8hA-4k5rA:
23.62
5b8hB-4k5rA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4k5r OXYGENASE
(Streptomyces
argillaceus) 		5 / 11 ALA A 124
ALA A 121
GLY A  35
GLY A  34
ALA A  33
 None
 0.87A 5bxnK-4k5rA:
undetectable
5bxnL-4k5rA:
undetectable		 5bxnK-4k5rA:
16.89
5bxnL-4k5rA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4k5r OXYGENASE
(Streptomyces
argillaceus) 		5 / 11 ALA A 124
ALA A 121
GLY A  35
GLY A  34
ALA A  33
 None
 0.88A 5bxnY-4k5rA:
undetectable
5bxnZ-4k5rA:
undetectable		 5bxnY-4k5rA:
16.89
5bxnZ-4k5rA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4k5r OXYGENASE
(Streptomyces
argillaceus) 		5 / 9 ALA A 124
ALA A 121
GLY A  35
GLY A  34
ALA A  33
 None
 0.87A 5d0xK-4k5rA:
undetectable
5d0xL-4k5rA:
undetectable		 5d0xK-4k5rA:
17.11
5d0xL-4k5rA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4k5r OXYGENASE
(Streptomyces
argillaceus) 		5 / 9 ALA A 124
ALA A 121
GLY A  35
GLY A  34
ALA A  33
 None
 0.88A 5d0xY-4k5rA:
undetectable
5d0xZ-4k5rA:
undetectable		 5d0xY-4k5rA:
17.11
5d0xZ-4k5rA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_B_010B607_0
(HNL ISOENZYME 5)		 4k5r OXYGENASE
(Streptomyces
argillaceus) 		5 / 10 ALA A 312
ALA A 290
VAL A 163
LEU A  25
VAL A  17
 None
 1.10A 5eb5B-4k5rA:
12.3		 5eb5B-4k5rA:
21.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KOX_A_RFPA502_1
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 4k5r OXYGENASE
(Streptomyces
argillaceus) 		5 / 12 GLY A  19
GLY A 177
ILE A 178
GLY A 168
GLY A 167
 FAD  A 601 (-3.4A)
None
None
None
FAD  A 601 (-3.6A)
 0.91A 5koxA-4k5rA:
53.4		 5koxA-4k5rA:
45.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 4k5r OXYGENASE
(Streptomyces
argillaceus) 		5 / 11 ALA A 124
ALA A  28
GLY A  35
GLY A  34
ALA A  33
 None
 0.94A 5lf7K-4k5rA:
undetectable
5lf7L-4k5rA:
undetectable		 5lf7K-4k5rA:
18.10
5lf7L-4k5rA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_Y_6V8Y306_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 4k5r OXYGENASE
(Streptomyces
argillaceus) 		5 / 11 ALA A 124
ALA A  28
GLY A  35
GLY A  34
ALA A  33
 None
 0.93A 5lf7Y-4k5rA:
undetectable
5lf7Z-4k5rA:
undetectable		 5lf7Y-4k5rA:
18.10
5lf7Z-4k5rA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA608_0
(ACETYLCHOLINESTERASE)		 4k5r OXYGENASE
(Streptomyces
argillaceus) 		4 / 7 THR A 307
LEU A 305
THR A  60
VAL A 108
 None
FAD  A 601 (-3.9A)
None
None
 0.89A 5ov9A-4k5rA:
undetectable		 5ov9A-4k5rA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4k5r OXYGENASE
(Streptomyces
argillaceus) 		4 / 8 THR A 105
THR A  60
ARG A  59
GLN A 310
 None
 1.27A 5tzoA-4k5rA:
undetectable		 5tzoA-4k5rA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4k5r OXYGENASE
(Streptomyces
argillaceus) 		4 / 8 THR A 105
THR A  60
ARG A  59
GLN A 310
 None
 1.33A 5tzoB-4k5rA:
undetectable		 5tzoB-4k5rA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4k5r OXYGENASE
(Streptomyces
argillaceus) 		4 / 8 THR A 105
THR A  60
ARG A  59
GLN A 310
 None
 1.29A 5tzoC-4k5rA:
undetectable		 5tzoC-4k5rA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_1
(RIFAMPIN
MONOOXYGENASE)		 4k5r OXYGENASE
(Streptomyces
argillaceus) 		5 / 12 HIS A  57
VAL A 227
PHE A 272
GLY A 301
MET A 357
 None
None
FAD  A 601 ( 4.2A)
None
None
 0.76A 6brdA-4k5rA:
53.4		 6brdA-4k5rA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_1
(RIFAMPIN
MONOOXYGENASE)		 4k5r OXYGENASE
(Streptomyces
argillaceus) 		5 / 12 HIS A  57
ARG A 225
PHE A 272
GLY A 302
MET A 357
 None
None
FAD  A 601 ( 4.2A)
FAD  A 601 (-3.4A)
None
 0.99A 6brdB-4k5rA:
53.0		 6brdB-4k5rA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_1
(RIFAMPIN
MONOOXYGENASE)		 4k5r OXYGENASE
(Streptomyces
argillaceus) 		5 / 12 HIS A  57
ARG A 225
VAL A 214
GLY A 302
MET A 357
 None
None
None
FAD  A 601 (-3.4A)
None
 0.97A 6brdB-4k5rA:
53.0		 6brdB-4k5rA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_1
(RIFAMPIN
MONOOXYGENASE)		 4k5r OXYGENASE
(Streptomyces
argillaceus) 		5 / 12 HIS A  57
VAL A 214
GLY A 301
GLY A 302
MET A 357
 None
None
None
FAD  A 601 (-3.4A)
None
 0.64A 6brdB-4k5rA:
53.0		 6brdB-4k5rA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_1
(RIFAMPIN
MONOOXYGENASE)		 4k5r OXYGENASE
(Streptomyces
argillaceus) 		6 / 12 HIS A  57
VAL A 227
PHE A 272
GLY A 301
GLY A 302
MET A 357
 None
None
FAD  A 601 ( 4.2A)
None
FAD  A 601 (-3.4A)
None
 0.80A 6brdB-4k5rA:
53.0		 6brdB-4k5rA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CJK_C_ACTC301_0
(IMMUNOGLOBULIN FAB
LIGHT CHAIN)		 4k5r OXYGENASE
(Streptomyces
argillaceus) 		4 / 4 VAL A  23
GLY A 291
ASP A 292
ASP A 166
 FAD  A 601 (-3.7A)
FAD  A 601 (-3.5A)
FAD  A 601 (-2.9A)
FAD  A 601 (-4.7A)
 1.25A 6cjkC-4k5rA:
undetectable		 6cjkC-4k5rA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_D_READ601_1
(RETINOIC ACID
RECEPTOR)		 4k5r OXYGENASE
(Streptomyces
argillaceus) 		5 / 7 VAL A  16
LEU A 288
GLY A 164
LEU A 175
GLY A 136
 None
 1.23A 6eu9D-4k5rA:
undetectable		 6eu9D-4k5rA:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_K_BO2K301_0
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4k5r OXYGENASE
(Streptomyces
argillaceus) 		6 / 11 ALA A 124
ALA A 126
ALA A 121
GLY A  35
GLY A  34
ALA A  33
 None
 1.34A 6hwdK-4k5rA:
undetectable
6hwdL-4k5rA:
undetectable		 6hwdK-4k5rA:
10.14
6hwdL-4k5rA:
8.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_Y_BO2Y301_0
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4k5r OXYGENASE
(Streptomyces
argillaceus) 		6 / 11 ALA A 124
ALA A 126
ALA A 121
GLY A  35
GLY A  34
ALA A  33
 None
 1.35A 6hwdY-4k5rA:
undetectable
6hwdZ-4k5rA:
undetectable		 6hwdY-4k5rA:
10.14
6hwdZ-4k5rA:
8.38