SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4k5y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA8_0
(GRAMICIDIN A)		 4k5y CORTICOTROPIN-RELEAS
ING FACTOR RECEPTOR
1, T4-LYSOZYME
CHIMERIC CONSTRUCT
(Homo
sapiens;
Escherichia
virus
T4) 		3 / 3 VAL A 200
TRP A 205
TRP A 236
 None
 1.02A 1c4dA-4k5yA:
undetectable
1c4dB-4k5yA:
undetectable		 1c4dA-4k5yA:
5.15
1c4dB-4k5yA:
5.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA8_0
(GRAMICIDIN A)		 4k5y CORTICOTROPIN-RELEAS
ING FACTOR RECEPTOR
1, T4-LYSOZYME
CHIMERIC CONSTRUCT
(Homo
sapiens;
Escherichia
virus
T4) 		3 / 3 VAL A 238
TRP A 236
TRP A 205
 OLA  A 501 ( 4.2A)
None
None
 1.07A 1c4dA-4k5yA:
undetectable
1c4dB-4k5yA:
undetectable		 1c4dA-4k5yA:
5.15
1c4dB-4k5yA:
5.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_A_CCSA47_0
(GLUTATHIONE
S-TRANSFERASE)		 4k5y CORTICOTROPIN-RELEAS
ING FACTOR RECEPTOR
1, T4-LYSOZYME
CHIMERIC CONSTRUCT
(Homo
sapiens;
Escherichia
virus
T4) 		4 / 7 LEU A1033
LEU A1015
GLY A1028
LEU A1066
 None
 0.89A 1gtiA-4k5yA:
undetectable		 1gtiA-4k5yA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_A_SAMA1300_0
(UPF0088 PROTEIN
AQ_165)		 4k5y CORTICOTROPIN-RELEAS
ING FACTOR RECEPTOR
1, T4-LYSOZYME
CHIMERIC CONSTRUCT
(Homo
sapiens;
Escherichia
virus
T4) 		5 / 12 LEU A1039
GLY A1023
THR A1026
LEU A1033
ALA A1042
 None
 1.06A 2egvA-4k5yA:
undetectable		 2egvA-4k5yA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D9L_A_ACTA501_0
(CTD-PEPTIDE
RNA-BINDING PROTEIN
16)		 4k5y CORTICOTROPIN-RELEAS
ING FACTOR RECEPTOR
1, T4-LYSOZYME
CHIMERIC CONSTRUCT
(Homo
sapiens;
Escherichia
virus
T4) 		4 / 5 PRO A 239
ILE A 242
PRO A 275
TYR A 272
 None
 1.20A 3d9lA-4k5yA:
1.4
3d9lY-4k5yA:
undetectable		 3d9lA-4k5yA:
16.18
3d9lY-4k5yA:
3.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_2
(PROTEASE)		 4k5y CORTICOTROPIN-RELEAS
ING FACTOR RECEPTOR
1, T4-LYSOZYME
CHIMERIC CONSTRUCT
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 10 ASP A 269
ILE A 271
GLY A 249
LEU A 251
ILE A 243
 None
 1.06A 3em4V-4k5yA:
undetectable		 3em4V-4k5yA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		 4k5y CORTICOTROPIN-RELEAS
ING FACTOR RECEPTOR
1, T4-LYSOZYME
CHIMERIC CONSTRUCT
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 9 LEU A1133
LEU A1121
ILE A1078
PHE A1114
VAL A1111
 None
None
None
SO4  A 504 (-4.9A)
None
 1.38A 3tmzA-4k5yA:
1.6		 3tmzA-4k5yA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_1
(PUTATIVE REGULATORY
PROTEIN)		 4k5y CORTICOTROPIN-RELEAS
ING FACTOR RECEPTOR
1, T4-LYSOZYME
CHIMERIC CONSTRUCT
(Homo
sapiens;
Escherichia
virus
T4) 		3 / 3 TYR A 195
MET A 206
LEU A 323
 None
1Q5  A 401 (-4.1A)
1Q5  A 401 ( 4.3A)
 0.85A 3vw1D-4k5yA:
2.4		 3vw1D-4k5yA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_B_ACTB1114_0
(BLR5658 PROTEIN)		 4k5y CORTICOTROPIN-RELEAS
ING FACTOR RECEPTOR
1, T4-LYSOZYME
CHIMERIC CONSTRUCT
(Homo
sapiens;
Escherichia
virus
T4) 		3 / 3 TRP A 259
TRP A 246
THR A 268
 None
 1.27A 4bboB-4k5yA:
undetectable		 4bboB-4k5yA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T44A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4k5y CORTICOTROPIN-RELEAS
ING FACTOR RECEPTOR
1, T4-LYSOZYME
CHIMERIC CONSTRUCT
(Escherichia
virus
T4;
Homo
sapiens) 		4 / 6 SER A 304
GLU A 305
GLN A 308
THR A1157
 None
 1.39A 4lnxA-4k5yA:
undetectable		 4lnxA-4k5yA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 4k5y CORTICOTROPIN-RELEAS
ING FACTOR RECEPTOR
1, T4-LYSOZYME
CHIMERIC CONSTRUCT
(Escherichia
virus
T4;
Homo
sapiens) 		3 / 3 PRO A 275
MET A 276
TYR A 272
 None
 0.84A 4qa2B-4k5yA:
undetectable		 4qa2B-4k5yA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4k5y CORTICOTROPIN-RELEAS
ING FACTOR RECEPTOR
1, T4-LYSOZYME
CHIMERIC CONSTRUCT
(Homo
sapiens;
Escherichia
virus
T4) 		4 / 7 ARG A1145
PHE A1004
ARG A1008
ILE A1029
 None
 1.24A 5a06B-4k5yA:
undetectable		 5a06B-4k5yA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 4k5y CORTICOTROPIN-RELEAS
ING FACTOR RECEPTOR
1, T4-LYSOZYME
CHIMERIC CONSTRUCT
(Homo
sapiens;
Escherichia
virus
T4) 		3 / 3 ARG A1008
LYS A1060
ARG A 292
 None
 0.90A 6c06D-4k5yA:
2.1		 6c06D-4k5yA:
undetectable