SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4k68'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A27_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)
4k68 GH10 XYLANASE
(soil
metagenome)
5 / 12 GLY A 184
MET A 183
MET A 223
VAL A 164
MET A 143
None
1.40A 1a27A-4k68A:
undetectable
1a27A-4k68A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_A_ACTA1117_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)
4k68 GH10 XYLANASE
(soil
metagenome)
3 / 3 ASP A 299
ARG A 298
ARG A 354
None
1.10A 2j9dA-4k68A:
undetectable
2j9dC-4k68A:
undetectable
2j9dA-4k68A:
16.36
2j9dC-4k68A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)
4k68 GH10 XYLANASE
(soil
metagenome)
5 / 12 MET A  79
ILE A  66
LEU A  63
GLY A 103
ILE A  73
None
1.30A 2ogyB-4k68A:
11.0
2ogyB-4k68A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)
4k68 GH10 XYLANASE
(soil
metagenome)
4 / 6 LEU A 260
LEU A 257
ILE A 220
ARG A 217
None
1.05A 2rlfB-4k68A:
undetectable
2rlfC-4k68A:
undetectable
2rlfB-4k68A:
7.39
2rlfC-4k68A:
7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YCJ_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)
4k68 GH10 XYLANASE
(soil
metagenome)
5 / 12 MET A  79
ILE A  66
LEU A  63
GLY A 103
ILE A  73
None
1.30A 2ycjA-4k68A:
7.0
2ycjA-4k68A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG801_0
(GLUTAMATE RECEPTOR 2)
4k68 GH10 XYLANASE
(soil
metagenome)
3 / 3 PRO A 350
SER A 279
ASN A 356
None
0.84A 3lslG-4k68A:
undetectable
3lslG-4k68A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)
4k68 GH10 XYLANASE
(soil
metagenome)
3 / 3 ARG A 363
GLU A 343
THR A 344
None
0.93A 3v4tA-4k68A:
undetectable
3v4tA-4k68A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_ACTA608_0
(SERUM ALBUMIN)
4k68 GH10 XYLANASE
(soil
metagenome)
3 / 3 LYS A 176
ARG A 175
HIS A 118
None
1.24A 4zbrA-4k68A:
undetectable
4zbrA-4k68A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_B_1FLB1375_1
(DNA POLYMERASE III
SUBUNIT BETA)
4k68 GH10 XYLANASE
(soil
metagenome)
5 / 9 LEU A  54
THR A  53
LEU A  62
ILE A  66
LEU A  65
None
1.43A 5g48B-4k68A:
undetectable
5g48B-4k68A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_F_Z80F401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)
4k68 GH10 XYLANASE
(soil
metagenome)
5 / 10 ILE A 253
ILE A 320
PHE A 321
ASP A 273
ILE A 269
None
1.18A 5lg3F-4k68A:
undetectable
5lg3F-4k68A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_J_Z80J401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)
4k68 GH10 XYLANASE
(soil
metagenome)
5 / 12 ILE A 253
ILE A 320
PHE A 321
ASP A 273
ILE A 269
None
1.18A 5lg3J-4k68A:
undetectable
5lg3J-4k68A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UVM_B_ADNB207_1
(HISTIDINE TRIAD
(HIT) PROTEIN)
4k68 GH10 XYLANASE
(soil
metagenome)
5 / 12 VAL A 125
PHE A 126
ILE A 134
ILE A 182
VAL A 121
None
0.92A 5uvmB-4k68A:
undetectable
5uvmB-4k68A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7B_B_PA1B204_1
(ACYLOXYACYL
HYDROLASE SMALL
SUBUNIT
ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT)
4k68 GH10 XYLANASE
(soil
metagenome)
3 / 3 GLY A 238
ASN A 207
ARG A 333
None
0.74A 5w7bD-4k68A:
undetectable
5w7bD-4k68A:
13.29