SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4k6c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_2
(PROTEIN (ADENOSINE
KINASE))		 4k6c ACETOACETYL-COA
REDUCTASE
(Burkholderia
cenocepacia) 		3 / 3 LEU A 221
SER A 182
ASN A 137
 None
 0.72A 1bx4A-4k6cA:
3.4		 1bx4A-4k6cA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_A_CFFA864_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4k6c ACETOACETYL-COA
REDUCTASE
(Burkholderia
cenocepacia) 		3 / 3 TRP A 132
HIS A  28
LYS A   3
 None
 1.30A 1l7xA-4k6cA:
3.1		 1l7xA-4k6cA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A600_1
(ORF12)		 4k6c ACETOACETYL-COA
REDUCTASE
(Burkholderia
cenocepacia) 		5 / 11 LYS A 165
SER A 139
ALA A 158
GLY A 143
SER A 144
 None
 1.46A 2xf3A-4k6cA:
undetectable		 2xf3A-4k6cA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_B_J01B600_1
(ORF12)		 4k6c ACETOACETYL-COA
REDUCTASE
(Burkholderia
cenocepacia) 		5 / 11 LYS A 165
SER A 139
ALA A 158
GLY A 143
SER A 144
 None
 1.44A 2xf3B-4k6cA:
undetectable		 2xf3B-4k6cA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)		 4k6c ACETOACETYL-COA
REDUCTASE
(Burkholderia
cenocepacia) 		5 / 12 GLN A 206
TYR A 153
GLY A 184
ILE A 207
GLY A 213
 None
 0.91A 3bwcA-4k6cA:
5.2		 3bwcA-4k6cA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA802_1
(CATALASE-PEROXIDASE)		 4k6c ACETOACETYL-COA
REDUCTASE
(Burkholderia
cenocepacia) 		4 / 8 LEU A 204
ILE A 207
ASN A 241
GLY A 184
 None
 0.90A 3wxoA-4k6cA:
undetectable		 3wxoA-4k6cA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 4k6c ACETOACETYL-COA
REDUCTASE
(Burkholderia
cenocepacia) 		4 / 8 ASP A 114
ASN A 118
THR A   9
GLY A  90
 None
 0.85A 4fo4A-4k6cA:
undetectable		 4fo4A-4k6cA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 4k6c ACETOACETYL-COA
REDUCTASE
(Burkholderia
cenocepacia) 		5 / 12 GLY A  14
GLY A  16
PRO A 215
ALA A 187
ALA A  89
 None
 1.22A 5bw4B-4k6cA:
6.1		 5bw4B-4k6cA:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4k6c ACETOACETYL-COA
REDUCTASE
(Burkholderia
cenocepacia) 		5 / 12 THR A   9
THR A 120
CYH A  68
ALA A  89
THR A 111
 None
 1.42A 5d0xH-4k6cA:
undetectable
5d0xI-4k6cA:
undetectable		 5d0xH-4k6cA:
22.65
5d0xI-4k6cA:
20.68