SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4k6j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		 4k6j WINGS APART-LIKE
PROTEIN HOMOLOG
(Homo
sapiens) 		5 / 12 ALA A 682
ILE A 726
LEU A 707
PHE A 704
LEU A 694
 None
 1.09A 1dtlA-4k6jA:
undetectable		 1dtlA-4k6jA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_B_CCSB47_0
(GLUTATHIONE
S-TRANSFERASE)		 4k6j WINGS APART-LIKE
PROTEIN HOMOLOG
(Homo
sapiens) 		4 / 7 LEU A1036
THR A1125
LEU A1127
GLY A1130
 None
 0.81A 1gtiB-4k6jA:
2.6		 1gtiB-4k6jA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_B_CCSB47_0
(GLUTATHIONE
S-TRANSFERASE)		 4k6j WINGS APART-LIKE
PROTEIN HOMOLOG
(Homo
sapiens) 		4 / 7 LEU A1036
THR A1125
LEU A1127
LEU A1132
 None
 0.94A 1gtiB-4k6jA:
2.6		 1gtiB-4k6jA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		 4k6j WINGS APART-LIKE
PROTEIN HOMOLOG
(Homo
sapiens) 		4 / 5 GLU A 859
THR A 941
LEU A 937
LEU A 940
 None
 1.01A 1u18B-4k6jA:
undetectable		 1u18B-4k6jA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2MJI_A_KTRA201_1
(FATTY ACID-BINDING
PROTEIN, INTESTINAL)		 4k6j WINGS APART-LIKE
PROTEIN HOMOLOG
(Homo
sapiens) 		5 / 12 MET A 724
ILE A 824
THR A 798
LEU A 802
LEU A 736
 None
 1.19A 2mjiA-4k6jA:
undetectable		 2mjiA-4k6jA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_B_ACTB653_0
(ACETYL-COENZYME A
SYNTHETASE)		 4k6j WINGS APART-LIKE
PROTEIN HOMOLOG
(Homo
sapiens) 		4 / 4 VAL A 863
THR A 862
VAL A 936
GLY A 935
 ACT  A1209 ( 3.1A)
None
None
None
 1.16A 2p2fB-4k6jA:
undetectable		 2p2fB-4k6jA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_C_TOPC1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4k6j WINGS APART-LIKE
PROTEIN HOMOLOG
(Homo
sapiens) 		5 / 10 ILE A 772
ALA A 682
ILE A 768
SER A 710
THR A 683
 None
 1.18A 2w9sC-4k6jA:
undetectable		 2w9sC-4k6jA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_D_TOPD1158_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4k6j WINGS APART-LIKE
PROTEIN HOMOLOG
(Homo
sapiens) 		5 / 10 ILE A 772
ALA A 682
ILE A 768
SER A 710
THR A 683
 None
 1.16A 2w9sD-4k6jA:
undetectable		 2w9sD-4k6jA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_F_TOPF1159_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4k6j WINGS APART-LIKE
PROTEIN HOMOLOG
(Homo
sapiens) 		5 / 10 ILE A 772
ALA A 682
ILE A 768
SER A 710
THR A 683
 None
 1.18A 2w9sF-4k6jA:
undetectable		 2w9sF-4k6jA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4k6j WINGS APART-LIKE
PROTEIN HOMOLOG
(Homo
sapiens) 		4 / 7 LEU A1163
ILE A 989
MET A1158
ARG A 931
 None
 1.32A 3ik3B-4k6jA:
undetectable		 3ik3B-4k6jA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 4k6j WINGS APART-LIKE
PROTEIN HOMOLOG
(Homo
sapiens) 		4 / 6 SER A 884
GLY A 947
GLU A 993
GLU A 945
 None
 1.17A 3k9fA-4k6jA:
undetectable
3k9fB-4k6jA:
undetectable
3k9fD-4k6jA:
undetectable		 3k9fA-4k6jA:
21.78
3k9fB-4k6jA:
21.78
3k9fD-4k6jA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_A_URFA2001_1
(URIDINE
PHOSPHORYLASE)		 4k6j WINGS APART-LIKE
PROTEIN HOMOLOG
(Homo
sapiens) 		5 / 10 GLY A1130
GLN A1134
LEU A1128
LEU A1127
ILE A 989
 None
 1.24A 3kvrA-4k6jA:
undetectable		 3kvrA-4k6jA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 4k6j WINGS APART-LIKE
PROTEIN HOMOLOG
(Homo
sapiens) 		5 / 10 GLY A1130
GLN A1134
LEU A1128
LEU A1127
ILE A 989
 None
 1.25A 3kvrB-4k6jA:
undetectable		 3kvrB-4k6jA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_A_URFA400_1
(URIDINE
PHOSPHORYLASE 1)		 4k6j WINGS APART-LIKE
PROTEIN HOMOLOG
(Homo
sapiens) 		5 / 9 GLY A1130
GLN A1134
LEU A1128
LEU A1127
ILE A 989
 None
 1.24A 3nbqA-4k6jA:
undetectable		 3nbqA-4k6jA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_D_URFD400_1
(URIDINE
PHOSPHORYLASE 1)		 4k6j WINGS APART-LIKE
PROTEIN HOMOLOG
(Homo
sapiens) 		5 / 9 GLY A1130
GLN A1134
LEU A1128
LEU A1127
ILE A 989
 None
 1.24A 3nbqD-4k6jA:
undetectable		 3nbqD-4k6jA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZU_A_X89A411_1
(FLAVOHEMOPROTEIN)		 4k6j WINGS APART-LIKE
PROTEIN HOMOLOG
(Homo
sapiens) 		5 / 12 ILE A 873
LEU A 940
VAL A 936
ALA A 887
LEU A 888
 None
 0.96A 3ozuA-4k6jA:
undetectable		 3ozuA-4k6jA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_H_LFXH101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 4k6j WINGS APART-LIKE
PROTEIN HOMOLOG
(Homo
sapiens) 		4 / 5 SER A 884
GLY A 947
GLU A 993
GLU A 945
 None
 1.18A 3raeB-4k6jA:
undetectable
3raeD-4k6jA:
undetectable		 3raeB-4k6jA:
21.78
3raeD-4k6jA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_B_ECNB403_1
(FLAVOHEMOGLOBIN)		 4k6j WINGS APART-LIKE
PROTEIN HOMOLOG
(Homo
sapiens) 		5 / 11 ILE A 658
LEU A 662
THR A 706
VAL A 703
LEU A 681
 None
 1.07A 4g1bB-4k6jA:
2.5		 4g1bB-4k6jA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_C_ECNC403_1
(FLAVOHEMOGLOBIN)		 4k6j WINGS APART-LIKE
PROTEIN HOMOLOG
(Homo
sapiens) 		5 / 9 ILE A 658
TYR A 660
LEU A 662
VAL A 703
LEU A 681
 None
 1.22A 4g1bC-4k6jA:
undetectable		 4g1bC-4k6jA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_D_ECND403_1
(FLAVOHEMOGLOBIN)		 4k6j WINGS APART-LIKE
PROTEIN HOMOLOG
(Homo
sapiens) 		5 / 12 ILE A 658
LEU A 662
THR A 706
VAL A 703
LEU A 681
 None
 1.07A 4g1bD-4k6jA:
2.2		 4g1bD-4k6jA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X30_A_T44A401_1
(THYROXINE-BINDING
GLOBULIN)		 4k6j WINGS APART-LIKE
PROTEIN HOMOLOG
(Homo
sapiens) 		5 / 9 ALA A1032
LEU A 987
LEU A1002
ASN A 998
LEU A 988
 None
 1.45A 4x30A-4k6jA:
undetectable		 4x30A-4k6jA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4k6j WINGS APART-LIKE
PROTEIN HOMOLOG
(Homo
sapiens) 		4 / 7 LEU A 681
THR A 720
LEU A 723
THR A 706
 None
 0.77A 4z90A-4k6jA:
3.2
4z90B-4k6jA:
3.4
4z90C-4k6jA:
3.4
4z90D-4k6jA:
3.4
4z90E-4k6jA:
3.2		 4z90A-4k6jA:
20.21
4z90B-4k6jA:
20.21
4z90C-4k6jA:
20.21
4z90D-4k6jA:
20.21
4z90E-4k6jA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_G_ADNG501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4k6j WINGS APART-LIKE
PROTEIN HOMOLOG
(Homo
sapiens) 		4 / 5 GLU A 852
GLU A 859
THR A 862
LEU A 880
 None
 1.26A 5hm8G-4k6jA:
undetectable		 5hm8G-4k6jA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		 4k6j WINGS APART-LIKE
PROTEIN HOMOLOG
(Homo
sapiens) 		4 / 8 LEU A 750
LEU A 747
MET A 724
THR A 798
 None
 1.12A 5hs6A-4k6jA:
undetectable		 5hs6A-4k6jA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_2
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 4k6j WINGS APART-LIKE
PROTEIN HOMOLOG
(Homo
sapiens) 		4 / 5 LEU A 747
CYH A 675
LEU A 671
ASP A 709
 None
 1.41A 5mafA-4k6jA:
undetectable		 5mafA-4k6jA:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 4k6j WINGS APART-LIKE
PROTEIN HOMOLOG
(Homo
sapiens) 		4 / 6 ASP A 822
LEU A 821
GLY A 820
TYR A 875
 None
 1.02A 5nooC-4k6jA:
undetectable		 5nooC-4k6jA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6M_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4k6j WINGS APART-LIKE
PROTEIN HOMOLOG
(Homo
sapiens) 		5 / 11 ALA A 739
ASP A 737
LEU A 736
LEU A 799
ILE A 745
 None
 1.03A 5z6mA-4k6jA:
undetectable		 5z6mA-4k6jA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_0
(SERUM ALBUMIN)		 4k6j WINGS APART-LIKE
PROTEIN HOMOLOG
(Homo
sapiens) 		5 / 12 ILE A 789
LYS A 827
VAL A 828
LEU A 858
CYH A 776
 None
 1.08A 6a7pA-4k6jA:
undetectable		 6a7pA-4k6jA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 4k6j WINGS APART-LIKE
PROTEIN HOMOLOG
(Homo
sapiens) 		3 / 3 HIS A 712
HIS A 713
ARG A 674
 None
 1.03A 6b58A-4k6jA:
3.2		 6b58A-4k6jA:
20.73