SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4k6l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EUP_A_ASDA452_1
(CYTOCHROME P450ERYF)
4k6l PUTATIVE
PERTUSSIS-LIKE TOXIN
SUBUNIT

(Salmonella
enterica)
4 / 8 TYR G  95
SER G 139
ILE G 140
LEU G 141
None
0.87A 1eupA-4k6lG:
undetectable
1eupA-4k6lG:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K4T_D_TTCD990_1
(DNA TOPOISOMERASE I)
4k6l CYTOLETHAL
DISTENDING TOXIN
SUBUNIT B HOMOLOG
PUTATIVE
PERTUSSIS-LIKE TOXIN
SUBUNIT

(Salmonella
enterica)
4 / 5 GLU G 188
ARG F 127
LYS F  28
ASP F  60
None
None
None
GOL  G 301 (-3.5A)
1.47A 1k4tA-4k6lG:
undetectable
1k4tA-4k6lG:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RRJ_B_TTCB990_1
(DNA TOPOISOMERASE I)
4k6l CYTOLETHAL
DISTENDING TOXIN
SUBUNIT B HOMOLOG
PUTATIVE
PERTUSSIS-LIKE TOXIN
SUBUNIT

(Salmonella
enterica)
4 / 5 GLU G 188
ARG F 127
LYS F  28
ASP F  60
None
None
None
GOL  G 301 (-3.5A)
1.43A 1rrjA-4k6lG:
undetectable
1rrjA-4k6lG:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RTS_A_D16A309_1
(THYMIDYLATE SYNTHASE)
4k6l CYTOLETHAL
DISTENDING TOXIN
SUBUNIT B HOMOLOG

(Salmonella
enterica)
4 / 8 ILE F 124
ASP F 131
LEU F 151
GLY F 150
None
0.75A 1rtsA-4k6lF:
undetectable
1rtsA-4k6lF:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_1
(SUN PROTEIN)
4k6l PUTATIVE
PERTUSSIS-LIKE TOXIN
SUBUNIT

(Salmonella
enterica)
3 / 3 PRO G  29
ASP G  26
ASP G  36
None
0.74A 1sqfA-4k6lG:
undetectable
1sqfA-4k6lG:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_A_ACTA1107_0
(C5A PEPTIDASE)
4k6l PUTATIVE
PERTUSSIS-LIKE TOXIN
SUBUNIT

(Salmonella
enterica)
4 / 5 LEU A 122
GLY A 124
HIS A 102
ILE A 101
None
0.98A 1xf1A-4k6lA:
undetectable
1xf1A-4k6lA:
8.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_B_MMZB501_1
(MONOOXYGENASE)
4k6l CYTOLETHAL
DISTENDING TOXIN
SUBUNIT B HOMOLOG
PUTATIVE
PERTUSSIS-LIKE TOXIN
SUBUNIT

(Salmonella
enterica)
3 / 3 ASN G 102
TYR F  27
SER G 139
None
GOL  G 301 ( 4.7A)
None
0.83A 2gvcB-4k6lG:
undetectable
2gvcB-4k6lG:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_E_MMZE501_1
(MONOOXYGENASE)
4k6l CYTOLETHAL
DISTENDING TOXIN
SUBUNIT B HOMOLOG
PUTATIVE
PERTUSSIS-LIKE TOXIN
SUBUNIT

(Salmonella
enterica)
3 / 3 ASN G 102
TYR F  27
SER G 139
None
GOL  G 301 ( 4.7A)
None
0.84A 2gvcE-4k6lG:
undetectable
2gvcE-4k6lG:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)
4k6l CYTOLETHAL
DISTENDING TOXIN
SUBUNIT B HOMOLOG
PUTATIVE
PERTUSSIS-LIKE TOXIN
SUBUNIT

(Salmonella
enterica)
4 / 7 ASP G  36
PRO F 242
SER G  39
LEU F 219
None
1.02A 2hdnE-4k6lG:
undetectable
2hdnF-4k6lG:
undetectable
2hdnH-4k6lG:
undetectable
2hdnE-4k6lG:
11.17
2hdnF-4k6lG:
20.00
2hdnH-4k6lG:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)
4k6l CYTOLETHAL
DISTENDING TOXIN
SUBUNIT B HOMOLOG
PUTATIVE
PERTUSSIS-LIKE TOXIN
SUBUNIT

(Salmonella
enterica)
4 / 7 SER G  39
LEU F 219
ASP G  36
PRO F 242
None
1.01A 2hdnF-4k6lG:
undetectable
2hdnG-4k6lG:
undetectable
2hdnH-4k6lG:
undetectable
2hdnF-4k6lG:
20.00
2hdnG-4k6lG:
11.17
2hdnH-4k6lG:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_D_CHDD702_0
(FERROCHELATASE)
4k6l PUTATIVE
PERTUSSIS-LIKE TOXIN
SUBUNIT

(Salmonella
enterica)
3 / 3 ARG G  85
GLY G 201
PRO G 202
None
0.42A 2hreD-4k6lG:
undetectable
2hreD-4k6lG:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)
4k6l PUTATIVE
PERTUSSIS-LIKE TOXIN
SUBUNIT

(Salmonella
enterica)
3 / 3 THR G  69
ASP G 162
SER G 165
None
0.84A 2nxeB-4k6lG:
undetectable
2nxeB-4k6lG:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_1
(PROTEASE)
4k6l PUTATIVE
PERTUSSIS-LIKE TOXIN
SUBUNIT

(Salmonella
enterica)
5 / 12 ALA A  89
GLY A 124
VAL A 123
VAL A  68
ILE A  55
None
1.12A 2o4lA-4k6lA:
undetectable
2o4lA-4k6lA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_A_D16A309_1
(THYMIDYLATE SYNTHASE)
4k6l CYTOLETHAL
DISTENDING TOXIN
SUBUNIT B HOMOLOG

(Salmonella
enterica)
4 / 7 ILE F 124
ASP F 131
LEU F 151
GLY F 150
None
0.75A 2tsrA-4k6lF:
undetectable
2tsrA-4k6lF:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_H_SAMH226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)
4k6l CYTOLETHAL
DISTENDING TOXIN
SUBUNIT B HOMOLOG
PUTATIVE
PERTUSSIS-LIKE TOXIN
SUBUNIT

(Salmonella
enterica;
Salmonella
enterica)
5 / 12 LEU G 138
GLY F 150
VAL F 133
GLY F 148
ILE F 124
None
1.01A 3ku1H-4k6lG:
undetectable
3ku1H-4k6lG:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA277_0
(UNIVERSAL STRESS
PROTEIN)
4k6l CYTOLETHAL
DISTENDING TOXIN
SUBUNIT B HOMOLOG
PUTATIVE
PERTUSSIS-LIKE TOXIN
SUBUNIT

(Salmonella
enterica;
Salmonella
enterica)
3 / 3 ASP F  26
SER G 139
ARG F 246
None
0.98A 3loqA-4k6lF:
undetectable
3loqA-4k6lF:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_A_PXLA400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)
4k6l PUTATIVE
PERTUSSIS-LIKE TOXIN
SUBUNIT

(Salmonella
enterica)
5 / 11 VAL G 149
GLN G  96
VAL G  72
TYR G  23
ASP G 162
None
1.33A 3mbhA-4k6lG:
undetectable
3mbhA-4k6lG:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_B_PXLB400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)
4k6l PUTATIVE
PERTUSSIS-LIKE TOXIN
SUBUNIT

(Salmonella
enterica)
5 / 12 VAL G 149
GLN G  96
VAL G  72
TYR G  23
ASP G 162
None
1.31A 3mbhB-4k6lG:
undetectable
3mbhB-4k6lG:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_C_PXLC400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)
4k6l PUTATIVE
PERTUSSIS-LIKE TOXIN
SUBUNIT

(Salmonella
enterica)
5 / 12 VAL G 149
GLN G  96
VAL G  72
TYR G  23
ASP G 162
None
1.36A 3mbhC-4k6lG:
undetectable
3mbhC-4k6lG:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_D_PXLD400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)
4k6l PUTATIVE
PERTUSSIS-LIKE TOXIN
SUBUNIT

(Salmonella
enterica)
5 / 12 VAL G 149
GLN G  96
VAL G  72
TYR G  23
ASP G 162
None
1.34A 3mbhD-4k6lG:
undetectable
3mbhD-4k6lG:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_E_PXLE400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)
4k6l PUTATIVE
PERTUSSIS-LIKE TOXIN
SUBUNIT

(Salmonella
enterica)
5 / 12 VAL G 149
GLN G  96
VAL G  72
TYR G  23
ASP G 162
None
1.34A 3mbhE-4k6lG:
undetectable
3mbhE-4k6lG:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_F_PXLF400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)
4k6l PUTATIVE
PERTUSSIS-LIKE TOXIN
SUBUNIT

(Salmonella
enterica)
5 / 11 VAL G 149
GLN G  96
VAL G  72
TYR G  23
ASP G 162
None
1.33A 3mbhF-4k6lG:
undetectable
3mbhF-4k6lG:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_2
(HIV-1 PROTEASE)
4k6l CYTOLETHAL
DISTENDING TOXIN
SUBUNIT B HOMOLOG

(Salmonella
enterica)
4 / 7 VAL F 155
GLY F 148
ILE F 147
VAL F 175
None
0.79A 3ufnB-4k6lF:
undetectable
3ufnB-4k6lF:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_B_D16B402_1
(THYMIDYLATE SYNTHASE)
4k6l CYTOLETHAL
DISTENDING TOXIN
SUBUNIT B HOMOLOG

(Salmonella
enterica)
4 / 7 ILE F 124
ASP F 131
LEU F 151
GLY F 150
None
0.76A 4iqqB-4k6lF:
undetectable
4iqqB-4k6lF:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_C_D16C402_1
(THYMIDYLATE SYNTHASE)
4k6l CYTOLETHAL
DISTENDING TOXIN
SUBUNIT B HOMOLOG

(Salmonella
enterica)
4 / 7 ILE F 124
ASP F 131
LEU F 151
GLY F 150
None
0.76A 4iqqC-4k6lF:
undetectable
4iqqC-4k6lF:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NNR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2)
4k6l CYTOLETHAL
DISTENDING TOXIN
SUBUNIT B HOMOLOG

(Salmonella
enterica)
5 / 12 PHE F 180
VAL F 155
ILE F 149
ARG F  79
ILE F  90
None
1.35A 4nnrA-4k6lF:
undetectable
4nnrB-4k6lF:
undetectable
4nnrA-4k6lF:
18.82
4nnrB-4k6lF:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)
4k6l CYTOLETHAL
DISTENDING TOXIN
SUBUNIT B HOMOLOG

(Salmonella
enterica)
5 / 12 ASP F 195
GLY F 235
ALA F 220
ILE F 231
ASP F 168
None
1.18A 4xe5A-4k6lF:
undetectable
4xe5A-4k6lF:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZO1_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)
4k6l PUTATIVE
PERTUSSIS-LIKE TOXIN
SUBUNIT

(Salmonella
enterica)
5 / 12 ILE G  78
ALA G  77
ARG G  80
LEU G 151
PHE G 208
None
1.19A 4zo1X-4k6lG:
undetectable
4zo1X-4k6lG:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_E_ACTE406_0
(PROTON-GATED ION
CHANNEL)
4k6l CYTOLETHAL
DISTENDING TOXIN
SUBUNIT B HOMOLOG

(Salmonella
enterica)
4 / 5 ILE F 149
ARG F 129
TYR F 109
GLU F  92
None
1.24A 4zzcE-4k6lF:
undetectable
4zzcE-4k6lF:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_E_ACTE406_0
(PROTON-GATED ION
CHANNEL)
4k6l CYTOLETHAL
DISTENDING TOXIN
SUBUNIT B HOMOLOG

(Salmonella
enterica)
4 / 5 ILE F 149
ILE F  81
TYR F 109
GLU F  92
None
1.10A 4zzcE-4k6lF:
undetectable
4zzcE-4k6lF:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CU6_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)
4k6l PUTATIVE
PERTUSSIS-LIKE TOXIN
SUBUNIT

(Salmonella
enterica)
4 / 6 TYR A  34
ILE A  55
VAL A 103
ALA A  69
None
0.81A 5cu6A-4k6lA:
undetectable
5cu6A-4k6lA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)
4k6l CYTOLETHAL
DISTENDING TOXIN
SUBUNIT B HOMOLOG
PUTATIVE
PERTUSSIS-LIKE TOXIN
SUBUNIT

(Salmonella
enterica;
Salmonella
enterica)
5 / 12 GLY F 152
PHE G 103
THR G 177
ASN G 144
HIS F 187
None
1.26A 5d0yA-4k6lF:
undetectable
5d0yA-4k6lF:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESJ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
4k6l PUTATIVE
PERTUSSIS-LIKE TOXIN
SUBUNIT

(Salmonella
enterica)
4 / 8 PHE G  38
ILE G 145
THR G  75
LEU G 151
None
0.92A 5esjA-4k6lG:
undetectable
5esjA-4k6lG:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_A_D16A402_1
(THYMIDYLATE SYNTHASE)
4k6l CYTOLETHAL
DISTENDING TOXIN
SUBUNIT B HOMOLOG

(Salmonella
enterica)
4 / 7 ILE F 124
ASP F 131
LEU F 151
GLY F 150
None
0.75A 5nooA-4k6lF:
undetectable
5nooA-4k6lF:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_B_D16B402_1
(THYMIDYLATE SYNTHASE)
4k6l CYTOLETHAL
DISTENDING TOXIN
SUBUNIT B HOMOLOG

(Salmonella
enterica)
4 / 7 ILE F 124
ASP F 131
LEU F 151
GLY F 150
None
0.77A 5nooB-4k6lF:
undetectable
5nooB-4k6lF:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)
4k6l PUTATIVE
PERTUSSIS-LIKE TOXIN
SUBUNIT

(Salmonella
enterica)
3 / 3 TYR G 225
ALA G  81
TYR G  82
None
0.88A 5uunB-4k6lG:
undetectable
5uunB-4k6lG:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_C_D16C402_1
(THYMIDYLATE SYNTHASE)
4k6l CYTOLETHAL
DISTENDING TOXIN
SUBUNIT B HOMOLOG

(Salmonella
enterica)
4 / 7 ILE F 124
ASP F 131
LEU F 151
GLY F 150
None
0.77A 5x5qC-4k6lF:
undetectable
5x5qC-4k6lF:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_D_D16D402_1
(THYMIDYLATE SYNTHASE)
4k6l CYTOLETHAL
DISTENDING TOXIN
SUBUNIT B HOMOLOG

(Salmonella
enterica)
4 / 8 ILE F 124
ASP F 131
LEU F 151
GLY F 150
None
0.81A 5x5qD-4k6lF:
undetectable
5x5qD-4k6lF:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_E_D16E402_1
(THYMIDYLATE SYNTHASE)
4k6l CYTOLETHAL
DISTENDING TOXIN
SUBUNIT B HOMOLOG

(Salmonella
enterica)
4 / 6 ILE F 124
ASP F 131
LEU F 151
GLY F 150
None
0.79A 5x5qE-4k6lF:
undetectable
5x5qE-4k6lF:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_F_D16F402_1
(THYMIDYLATE SYNTHASE)
4k6l CYTOLETHAL
DISTENDING TOXIN
SUBUNIT B HOMOLOG

(Salmonella
enterica)
4 / 8 ILE F 124
ASP F 131
LEU F 151
GLY F 150
None
0.81A 5x5qF-4k6lF:
undetectable
5x5qF-4k6lF:
18.71