SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4k6n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDW_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 4k6n AMINODEOXYCHORISMATE
LYASE
(Saccharomyces
cerevisiae) 		5 / 10 VAL A 305
LEU A 350
PRO A 319
SER A 289
GLU A 285
 None
 1.37A 1fdwA-4k6nA:
undetectable		 1fdwA-4k6nA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		 4k6n AMINODEOXYCHORISMATE
LYASE
(Saccharomyces
cerevisiae) 		4 / 5 GLU A 153
LEU A 147
LEU A 150
LEU A 148
 None
 1.18A 1np1A-4k6nA:
undetectable		 1np1A-4k6nA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA471_1
(CYTOCHROME P450 51)		 4k6n AMINODEOXYCHORISMATE
LYASE
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 258
PHE A 288
LEU A 326
MET A 296
 PLP  A 500 (-3.6A)
None
PLP  A 500 (-4.1A)
None
 1.11A 1x8vA-4k6nA:
undetectable		 1x8vA-4k6nA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_1
(ANDROGEN RECEPTOR)		 4k6n AMINODEOXYCHORISMATE
LYASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 326
GLY A 328
ARG A 255
THR A 318
ILE A 340
 PLP  A 500 (-4.1A)
PLP  A 500 (-3.4A)
PLP  A 500 (-3.0A)
None
None
 1.24A 1z95A-4k6nA:
undetectable		 1z95A-4k6nA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZUC_A_T98A201_1
(PROGESTERONE
RECEPTOR)		 4k6n AMINODEOXYCHORISMATE
LYASE
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 335
GLN A 125
LEU A 321
THR A 318
PHE A 359
 None
PLP  A 500 ( 4.3A)
None
None
None
 1.13A 1zucA-4k6nA:
undetectable		 1zucA-4k6nA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZUC_B_T98B202_1
(PROGESTERONE
RECEPTOR)		 4k6n AMINODEOXYCHORISMATE
LYASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 335
GLN A 125
LEU A 321
THR A 318
PHE A 359
 None
PLP  A 500 ( 4.3A)
None
None
None
 1.20A 1zucB-4k6nA:
undetectable		 1zucB-4k6nA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4k6n AMINODEOXYCHORISMATE
LYASE
(Saccharomyces
cerevisiae) 		5 / 10 GLY A  84
LEU A  86
LEU A  87
ILE A  90
LEU A 334
 None
 0.87A 2f8dA-4k6nA:
undetectable		 2f8dA-4k6nA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_B_BEZB1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4k6n AMINODEOXYCHORISMATE
LYASE
(Saccharomyces
cerevisiae) 		5 / 10 GLY A  84
LEU A  86
LEU A  87
ILE A  90
LEU A 334
 None
 0.89A 2f8dB-4k6nA:
undetectable		 2f8dB-4k6nA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 4k6n AMINODEOXYCHORISMATE
LYASE
(Saccharomyces
cerevisiae) 		5 / 12 THR A  30
GLY A 328
THR A 329
GLY A 361
LEU A 242
 None
PLP  A 500 (-3.4A)
PLP  A 500 (-3.1A)
PLP  A 500 (-3.7A)
None
 1.04A 2y7hB-4k6nA:
undetectable		 2y7hB-4k6nA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 4k6n AMINODEOXYCHORISMATE
LYASE
(Saccharomyces
cerevisiae) 		5 / 12 THR A  30
GLY A 328
THR A 329
GLY A 361
LEU A 242
 None
PLP  A 500 (-3.4A)
PLP  A 500 (-3.1A)
PLP  A 500 (-3.7A)
None
 1.04A 2y7hC-4k6nA:
undetectable		 2y7hC-4k6nA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNE_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 4k6n AMINODEOXYCHORISMATE
LYASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 361
GLN A 125
THR A 318
ILE A 340
PHE A 359
 PLP  A 500 (-3.7A)
PLP  A 500 ( 4.3A)
None
None
None
 1.49A 3mneA-4k6nA:
undetectable		 3mneA-4k6nA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SNF_A_ACTA110_0
(PROTEIN P-30)		 4k6n AMINODEOXYCHORISMATE
LYASE
(Saccharomyces
cerevisiae) 		4 / 5 THR A 252
THR A 253
SER A 254
PHE A 247
 None
 1.03A 3snfA-4k6nA:
undetectable		 3snfA-4k6nA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VM4_A_IZPA1_1
(FATTY ACID
ALPHA-HYDROXYLASE)		 4k6n AMINODEOXYCHORISMATE
LYASE
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 326
PHE A 250
ARG A 128
ALA A 132
 PLP  A 500 (-4.1A)
None
PLP  A 500 (-2.7A)
None
 0.99A 3vm4A-4k6nA:
undetectable		 3vm4A-4k6nA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4k6n AMINODEOXYCHORISMATE
LYASE
(Saccharomyces
cerevisiae) 		5 / 7 GLY A 189
THR A 188
ILE A 138
THR A 253
PHE A  25
 None
 1.21A 4acaC-4k6nA:
undetectable		 4acaC-4k6nA:
25.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7B_C_ACTC513_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4k6n AMINODEOXYCHORISMATE
LYASE
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 258
HIS A 257
ARG A 255
 PLP  A 500 (-3.6A)
None
PLP  A 500 (-3.0A)
 1.05A 4e7bC-4k6nA:
undetectable		 4e7bC-4k6nA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_1
(ANDROGEN RECEPTOR)		 4k6n AMINODEOXYCHORISMATE
LYASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 326
GLY A 328
ARG A 255
THR A 318
ILE A 340
 PLP  A 500 (-4.1A)
PLP  A 500 (-3.4A)
PLP  A 500 (-3.0A)
None
None
 1.26A 4okbA-4k6nA:
undetectable		 4okbA-4k6nA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKT_A_198A1001_1
(ANDROGEN RECEPTOR)		 4k6n AMINODEOXYCHORISMATE
LYASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 326
GLY A 328
ARG A 255
THR A 318
ILE A 340
 PLP  A 500 (-4.1A)
PLP  A 500 (-3.4A)
PLP  A 500 (-3.0A)
None
None
 1.27A 4oktA-4k6nA:
undetectable		 4oktA-4k6nA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_1
(ANDROGEN RECEPTOR)		 4k6n AMINODEOXYCHORISMATE
LYASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 326
GLY A 328
ARG A 255
THR A 318
ILE A 340
 PLP  A 500 (-4.1A)
PLP  A 500 (-3.4A)
PLP  A 500 (-3.0A)
None
None
 1.25A 4okwA-4k6nA:
undetectable		 4okwA-4k6nA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_1
(GLUCOCORTICOID
RECEPTOR)		 4k6n AMINODEOXYCHORISMATE
LYASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 361
GLN A 125
THR A 318
ILE A 340
PHE A 359
 PLP  A 500 (-3.7A)
PLP  A 500 ( 4.3A)
None
None
None
 1.50A 4udcA-4k6nA:
undetectable		 4udcA-4k6nA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)		 4k6n AMINODEOXYCHORISMATE
LYASE
(Saccharomyces
cerevisiae) 		3 / 3 ASP A  99
ARG A 176
ARG A 118
 None
 0.96A 5eajB-4k6nA:
undetectable		 5eajB-4k6nA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGZ_A_SPRA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4k6n AMINODEOXYCHORISMATE
LYASE
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 334
ILE A 366
GLU A 285
PHE A 359
VAL A 303
 None
 1.48A 5igzA-4k6nA:
undetectable		 5igzA-4k6nA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_1
(CYTOCHROME P450 3A4)		 4k6n AMINODEOXYCHORISMATE
LYASE
(Saccharomyces
cerevisiae) 		5 / 12 ARG A 260
SER A 299
ILE A 300
ILE A 269
ALA A 268
 None
 1.14A 5vc0A-4k6nA:
undetectable		 5vc0A-4k6nA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4k6n AMINODEOXYCHORISMATE
LYASE
(Saccharomyces
cerevisiae) 		4 / 5 ARG A 331
MET A 330
THR A 329
LEU A 121
 None
None
PLP  A 500 (-3.1A)
None
 1.33A 5w97J-4k6nA:
undetectable		 5w97J-4k6nA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 4k6n AMINODEOXYCHORISMATE
LYASE
(Saccharomyces
cerevisiae) 		3 / 3 ASP A  52
LEU A  55
ARG A 336
 None
 0.85A 7dfrA-4k6nA:
undetectable		 7dfrA-4k6nA:
19.48