SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4k6x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA508_0
(CHORISMATE SYNTHASE)		 4k6x DISULFIDE
OXIDOREDUCTASE
(Mycobacterium
tuberculosis) 		4 / 5 ARG A 150
ASP A 115
ALA A 113
ILE A 146
 None
 1.12A 2qhfA-4k6xA:
undetectable		 2qhfA-4k6xA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		 4k6x DISULFIDE
OXIDOREDUCTASE
(Mycobacterium
tuberculosis) 		4 / 8 PRO A 215
PRO A  90
GLN A 162
GLU A 165
 None
EPE  A 301 (-3.5A)
None
None
 1.03A 3oyaA-4k6xA:
undetectable		 3oyaA-4k6xA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3M_A_DLUA398_1
(PFV INTEGRASE)		 4k6x DISULFIDE
OXIDOREDUCTASE
(Mycobacterium
tuberculosis) 		4 / 8 ASP A  59
GLY A  58
TYR A  84
ARG A 218
 None
 1.04A 3s3mA-4k6xA:
undetectable		 3s3mA-4k6xA:
18.72