SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4k70'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4k70 UL37
(Suid
alphaherpesvirus
1) 		5 / 12 ALA A 304
ALA A 305
ARG A 254
VAL A 238
LEU A 294
 None
 0.96A 1fm6A-4k70A:
undetectable		 1fm6A-4k70A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_U_9CRU502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4k70 UL37
(Suid
alphaherpesvirus
1) 		5 / 12 ALA A 304
ALA A 305
ARG A 254
VAL A 238
LEU A 294
 None
 0.91A 1fm6U-4k70A:
undetectable		 1fm6U-4k70A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4k70 UL37
(Suid
alphaherpesvirus
1) 		5 / 12 ALA A 304
ALA A 305
ARG A 254
VAL A 238
LEU A 294
 None
 0.89A 1fm9A-4k70A:
undetectable		 1fm9A-4k70A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA6_0
(GRAMICIDIN A)		 4k70 UL37
(Suid
alphaherpesvirus
1) 		3 / 3 ALA A 165
VAL A 160
TRP A 126
 None
 1.02A 1gmkA-4k70A:
undetectable
1gmkB-4k70A:
undetectable		 1gmkA-4k70A:
16.90
1gmkB-4k70A:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)		 4k70 UL37
(Suid
alphaherpesvirus
1) 		5 / 12 ALA A  61
LEU A  68
LEU A 103
ALA A 102
THR A  56
 None
 1.45A 1jipA-4k70A:
undetectable		 1jipA-4k70A:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4k70 UL37
(Suid
alphaherpesvirus
1) 		5 / 12 ALA A 304
ALA A 305
ARG A 254
VAL A 238
LEU A 294
 None
 0.94A 1k74A-4k70A:
undetectable		 1k74A-4k70A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4k70 UL37
(Suid
alphaherpesvirus
1) 		4 / 5 LEU A 414
VAL A 422
ALA A 327
CYH A 426
 None
 1.17A 1mz9D-4k70A:
undetectable		 1mz9D-4k70A:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_B_9CRB202_1
(RXR-LIKE PROTEIN)		 4k70 UL37
(Suid
alphaherpesvirus
1) 		5 / 12 ALA A 304
ALA A 305
ARG A 254
VAL A 238
LEU A 294
 None
 0.77A 1xiuB-4k70A:
undetectable		 1xiuB-4k70A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_A_9CRA801_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4k70 UL37
(Suid
alphaherpesvirus
1) 		5 / 12 ALA A 304
ALA A 305
ARG A 254
VAL A 238
LEU A 294
 None
 0.86A 1xlsA-4k70A:
undetectable		 1xlsA-4k70A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_B_9CRB802_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4k70 UL37
(Suid
alphaherpesvirus
1) 		5 / 12 ALA A 304
ALA A 305
ARG A 254
VAL A 238
LEU A 294
 None
 0.85A 1xlsB-4k70A:
undetectable		 1xlsB-4k70A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_C_9CRC803_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4k70 UL37
(Suid
alphaherpesvirus
1) 		5 / 12 ALA A 304
ALA A 305
ARG A 254
VAL A 238
LEU A 294
 None
 0.86A 1xlsC-4k70A:
undetectable		 1xlsC-4k70A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_D_9CRD804_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4k70 UL37
(Suid
alphaherpesvirus
1) 		5 / 12 ALA A 304
ALA A 305
ARG A 254
VAL A 238
LEU A 294
 None
 0.86A 1xlsD-4k70A:
undetectable		 1xlsD-4k70A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4k70 UL37
(Suid
alphaherpesvirus
1) 		5 / 12 LEU A  64
GLY A  70
ARG A  75
ASN A  67
ALA A 439
 None
 1.18A 2bm9B-4k70A:
undetectable		 2bm9B-4k70A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HZQ_A_STRA300_1
(APOLIPOPROTEIN D)		 4k70 UL37
(Suid
alphaherpesvirus
1) 		4 / 7 THR A 342
ALA A 270
TYR A 271
LEU A 227
 None
 1.09A 2hzqA-4k70A:
undetectable		 2hzqA-4k70A:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4k70 UL37
(Suid
alphaherpesvirus
1) 		5 / 12 ALA A 304
ALA A 305
ARG A 254
VAL A 238
LEU A 294
 None
 0.90A 3h0aA-4k70A:
undetectable		 3h0aA-4k70A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OAP_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4k70 UL37
(Suid
alphaherpesvirus
1) 		5 / 12 ALA A 304
ALA A 305
ARG A 254
VAL A 238
LEU A 294
 None
 0.88A 3oapA-4k70A:
undetectable		 3oapA-4k70A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZU_A_X89A411_1
(FLAVOHEMOPROTEIN)		 4k70 UL37
(Suid
alphaherpesvirus
1) 		5 / 12 ALA A 266
LEU A 265
VAL A 261
LEU A 205
ALA A 305
 None
 1.31A 3ozuA-4k70A:
undetectable		 3ozuA-4k70A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O4D_A_ACTA406_0
(INOSITOL
HEXAKISPHOSPHATE
KINASE)		 4k70 UL37
(Suid
alphaherpesvirus
1) 		4 / 7 ASP A 308
THR A 286
ARG A 283
HIS A 311
 None
 1.33A 4o4dA-4k70A:
undetectable		 4o4dA-4k70A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4USW_A_ACTA1470_0
(ADENYLATE CYCLASE
TYPE 10)		 4k70 UL37
(Suid
alphaherpesvirus
1) 		4 / 6 LEU A  73
LEU A 122
VAL A 123
PHE A 114
 None
 1.12A 4uswA-4k70A:
undetectable		 4uswA-4k70A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_B_HISB302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4k70 UL37
(Suid
alphaherpesvirus
1) 		5 / 10 GLY A 375
VAL A 373
VAL A 376
LEU A 354
LEU A 401
 None
 1.20A 4yb6B-4k70A:
undetectable
4yb6C-4k70A:
undetectable		 4yb6B-4k70A:
21.76
4yb6C-4k70A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_B_ACTB1321_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT)		 4k70 UL37
(Suid
alphaherpesvirus
1) 		3 / 3 THR A 361
ASP A 362
ALA A 363
 None
GOL  A1001 (-4.7A)
None
 0.00A 5g5gB-4k70A:
undetectable		 5g5gB-4k70A:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 4k70 UL37
(Suid
alphaherpesvirus
1) 		5 / 9 ALA A 316
THR A 317
ALA A 366
GLY A 297
ALA A 339
 None
None
GOL  A1001 ( 4.2A)
None
None
 1.07A 5l5zK-4k70A:
undetectable
5l5zL-4k70A:
undetectable		 5l5zK-4k70A:
17.48
5l5zL-4k70A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 4k70 UL37
(Suid
alphaherpesvirus
1) 		5 / 9 ALA A 316
THR A 317
ALA A 366
GLY A 297
ALA A 339
 None
None
GOL  A1001 ( 4.2A)
None
None
 1.07A 5l5zY-4k70A:
undetectable
5l5zZ-4k70A:
undetectable		 5l5zY-4k70A:
17.48
5l5zZ-4k70A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1103_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 4k70 UL37
(Suid
alphaherpesvirus
1) 		4 / 8 ASP A 315
VAL A 290
GLY A 289
ARG A 285
 None
 1.03A 5nzyA-4k70A:
undetectable		 5nzyA-4k70A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA810_1
(CATALASE-PEROXIDASE)		 4k70 UL37
(Suid
alphaherpesvirus
1) 		4 / 6 ARG A 430
LEU A 381
PRO A 152
SER A 328
 None
 1.47A 5syjA-4k70A:
undetectable		 5syjA-4k70A:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB810_1
(CATALASE-PEROXIDASE)		 4k70 UL37
(Suid
alphaherpesvirus
1) 		4 / 6 ARG A 430
LEU A 381
PRO A 152
SER A 328
 None
 1.49A 5syjB-4k70A:
undetectable		 5syjB-4k70A:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_1
(REGULATORY PROTEIN
TETR)		 4k70 UL37
(Suid
alphaherpesvirus
1) 		4 / 8 GLY A 387
ARG A 476
ASP A 169
ASP A 175
 None
 0.98A 5vlmB-4k70A:
undetectable		 5vlmB-4k70A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_1
(CYTOCHROME P450 2C9)		 4k70 UL37
(Suid
alphaherpesvirus
1) 		5 / 12 VAL A  94
LEU A  76
GLY A  70
ALA A  69
LEU A  91
 None
 1.43A 5x23A-4k70A:
undetectable		 5x23A-4k70A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4k70 UL37
(Suid
alphaherpesvirus
1) 		5 / 12 ALA A 304
ALA A 305
ARG A 254
VAL A 238
LEU A 294
 None
 0.89A 5z12B-4k70A:
undetectable		 5z12B-4k70A:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_C_9CRC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4k70 UL37
(Suid
alphaherpesvirus
1) 		5 / 12 ALA A 304
ALA A 305
ARG A 254
VAL A 238
LEU A 294
 None
 0.84A 5z12C-4k70A:
undetectable		 5z12C-4k70A:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4k70 UL37
(Suid
alphaherpesvirus
1) 		3 / 3 GLN A 174
TRP A 477
VAL A 436
 None
 1.08A 6auuA-4k70A:
undetectable		 6auuA-4k70A:
21.13