SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4k73'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4k73 L,D-TRANSPEPTIDASE
(Mycobacterium
tuberculosis) 		6 / 12 PHE A 121
GLY A 124
GLY A  50
PHE A 103
GLN A  47
ALA A 106
 None
 1.45A 3dh0B-4k73A:
undetectable		 3dh0B-4k73A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GVU_A_STIA1001_2
(TYROSINE-PROTEIN
KINASE ABL2)		 4k73 L,D-TRANSPEPTIDASE
(Mycobacterium
tuberculosis) 		4 / 5 LYS A 189
VAL A  48
ILE A 263
TYR A 184
 None
CA  A 301 (-4.9A)
None
None
 1.30A 3gvuA-4k73A:
undetectable		 3gvuA-4k73A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4k73 L,D-TRANSPEPTIDASE
(Mycobacterium
tuberculosis) 		4 / 6 PRO A 125
GLU A 190
ALA A 254
LEU A 249
 None
 1.03A 5igiA-4k73A:
undetectable		 5igiA-4k73A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4k73 L,D-TRANSPEPTIDASE
(Mycobacterium
tuberculosis) 		3 / 3 HIS A 244
SER A 197
LYS A 209
 None
 1.49A 5os7A-4k73A:
undetectable		 5os7A-4k73A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_B_ACTB402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4k73 L,D-TRANSPEPTIDASE
(Mycobacterium
tuberculosis) 		3 / 3 HIS A 244
SER A 197
LYS A 209
 None
 1.49A 6gmdB-4k73A:
undetectable		 6gmdB-4k73A:
22.19