SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4k7c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4k7c AMINOPEPTIDASE C
(Lactobacillus
rhamnosus) 		4 / 5 GLY A 370
ILE A  54
TRP A 381
SER A  53
 None
 0.83A 1rs7A-4k7cA:
undetectable		 1rs7A-4k7cA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4k7c AMINOPEPTIDASE C
(Lactobacillus
rhamnosus) 		4 / 6 GLY A 370
ILE A  54
TRP A 381
SER A  53
 None
 0.74A 1rs7B-4k7cA:
undetectable		 1rs7B-4k7cA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 4k7c AMINOPEPTIDASE C
(Lactobacillus
rhamnosus) 		6 / 10 GLN A  64
GLY A  68
TRP A  71
PHE A  73
HIS A 364
ALA A 365
 None
 0.63A 1stfE-4k7cA:
7.9
1stfI-4k7cA:
undetectable		 1stfE-4k7cA:
19.73
1stfI-4k7cA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 4k7c AMINOPEPTIDASE C
(Lactobacillus
rhamnosus) 		4 / 7 GLN A  64
GLY A  68
HIS A 364
TRP A 387
 None
 0.31A 3ai8A-4k7cA:
13.7		 3ai8A-4k7cA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 4k7c AMINOPEPTIDASE C
(Lactobacillus
rhamnosus) 		3 / 3 LEU A 257
VAL A 285
ARG A 289
 None
 0.83A 3b0wB-4k7cA:
undetectable		 3b0wB-4k7cA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4k7c AMINOPEPTIDASE C
(Lactobacillus
rhamnosus) 		4 / 7 PHE A 397
GLU A 384
SER A 386
VAL A  61
 None
 1.19A 3dqtA-4k7cA:
undetectable
3dqtB-4k7cA:
undetectable		 3dqtA-4k7cA:
20.85
3dqtB-4k7cA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_A_TOPA200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4k7c AMINOPEPTIDASE C
(Lactobacillus
rhamnosus) 		5 / 10 ALA A 399
LEU A 368
ALA A 305
ILE A 306
LEU A 373
 None
 1.19A 3fl9A-4k7cA:
undetectable		 3fl9A-4k7cA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_F_TOPF200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4k7c AMINOPEPTIDASE C
(Lactobacillus
rhamnosus) 		5 / 10 ALA A 399
LEU A 368
ALA A 305
ILE A 306
LEU A 373
 None
 1.16A 3fl9F-4k7cA:
undetectable		 3fl9F-4k7cA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5T_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 4k7c AMINOPEPTIDASE C
(Lactobacillus
rhamnosus) 		4 / 7 SER A 386
VAL A  61
PHE A 397
GLU A 384
 None
 1.18A 3n5tA-4k7cA:
undetectable
3n5tB-4k7cA:
undetectable		 3n5tA-4k7cA:
20.94
3n5tB-4k7cA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 4k7c AMINOPEPTIDASE C
(Lactobacillus
rhamnosus) 		4 / 7 PHE A 397
GLU A 384
SER A 386
VAL A  61
 None
 1.14A 3n61A-4k7cA:
undetectable
3n61B-4k7cA:
undetectable		 3n61A-4k7cA:
21.11
3n61B-4k7cA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4k7c AMINOPEPTIDASE C
(Lactobacillus
rhamnosus) 		4 / 8 PHE A 397
GLU A 384
SER A 386
VAL A  61
 None
 1.13A 3nlrA-4k7cA:
undetectable
3nlrB-4k7cA:
undetectable		 3nlrA-4k7cA:
21.11
3nlrB-4k7cA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP1_A_ACTA590_0
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4k7c AMINOPEPTIDASE C
(Lactobacillus
rhamnosus) 		4 / 5 GLU A  93
GLN A  84
HIS A  81
GLY A  59
 GOL  A 505 (-4.0A)
None
None
None
 1.05A 3pp1A-4k7cA:
0.5		 3pp1A-4k7cA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_ACTA803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4k7c AMINOPEPTIDASE C
(Lactobacillus
rhamnosus) 		4 / 6 GLY A 370
ILE A  54
TRP A 381
SER A  53
 None
 0.82A 4kcnA-4k7cA:
undetectable		 4kcnA-4k7cA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA306_1
(CHITOSANASE)		 4k7c AMINOPEPTIDASE C
(Lactobacillus
rhamnosus) 		3 / 3 SER A 146
ASP A 143
GLN A 261
 None
 0.66A 4oltA-4k7cA:
0.3
4oltB-4k7cA:
0.3		 4oltA-4k7cA:
18.89
4oltB-4k7cA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 4k7c AMINOPEPTIDASE C
(Lactobacillus
rhamnosus) 		4 / 6 LEU A 309
HIS A  81
TYR A 396
GLU A 384
 None
 0.88A 4pahA-4k7cA:
undetectable		 4pahA-4k7cA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB304_1
(CHITOSANASE)		 4k7c AMINOPEPTIDASE C
(Lactobacillus
rhamnosus) 		3 / 3 GLN A 261
SER A 146
ASP A 143
 None
 0.72A 4qwpA-4k7cA:
0.3
4qwpB-4k7cA:
undetectable		 4qwpA-4k7cA:
18.67
4qwpB-4k7cA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_A_NOVA2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 4k7c AMINOPEPTIDASE C
(Lactobacillus
rhamnosus) 		5 / 11 ASN A  41
SER A  44
ASP A  43
ASP A 333
THR A 334
 GOL  A 503 (-4.4A)
None
GOL  A 503 (-2.9A)
None
None
 1.35A 4urnA-4k7cA:
undetectable		 4urnA-4k7cA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADL_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 4k7c AMINOPEPTIDASE C
(Lactobacillus
rhamnosus) 		4 / 7 PHE A 397
GLU A 384
SER A 386
VAL A  61
 None
 1.20A 5adlA-4k7cA:
undetectable
5adlB-4k7cA:
undetectable		 5adlA-4k7cA:
20.99
5adlB-4k7cA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ3_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4k7c AMINOPEPTIDASE C
(Lactobacillus
rhamnosus) 		4 / 7 PHE A 397
GLU A 384
SER A 386
VAL A  61
 None
 1.23A 5fj3A-4k7cA:
undetectable
5fj3B-4k7cA:
undetectable		 5fj3A-4k7cA:
20.99
5fj3B-4k7cA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV7_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4k7c AMINOPEPTIDASE C
(Lactobacillus
rhamnosus) 		4 / 7 PHE A 397
GLU A 384
SER A 386
VAL A  61
 None
 1.25A 5vv7A-4k7cA:
undetectable
5vv7B-4k7cA:
undetectable		 5vv7A-4k7cA:
20.99
5vv7B-4k7cA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVN_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4k7c AMINOPEPTIDASE C
(Lactobacillus
rhamnosus) 		4 / 7 PHE A 397
GLU A 384
SER A 386
VAL A  61
 None
 1.23A 5vvnA-4k7cA:
undetectable
5vvnB-4k7cA:
undetectable		 5vvnA-4k7cA:
20.99
5vvnB-4k7cA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 4k7c AMINOPEPTIDASE C
(Lactobacillus
rhamnosus) 		4 / 5 LEU A 187
LYS A 204
LEU A 116
GLU A 113
 None
 1.26A 5weaA-4k7cA:
undetectable		 5weaA-4k7cA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB501_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4k7c AMINOPEPTIDASE C
(Lactobacillus
rhamnosus) 		4 / 7 SER A 386
VAL A  61
PHE A 397
GLU A 384
 None
 1.21A 6av6A-4k7cA:
undetectable
6av6B-4k7cA:
undetectable		 6av6A-4k7cA:
10.96
6av6B-4k7cA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4k7c AMINOPEPTIDASE C
(Lactobacillus
rhamnosus) 		4 / 7 PHE A 397
GLU A 384
SER A 386
VAL A  61
 None
 1.22A 6av6C-4k7cA:
undetectable
6av6D-4k7cA:
0.3		 6av6C-4k7cA:
10.96
6av6D-4k7cA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_B_FK5B201_0
(PEPTIDYLPROLYL
ISOMERASE)		 4k7c AMINOPEPTIDASE C
(Lactobacillus
rhamnosus) 		5 / 12 ASP A 303
PHE A 404
VAL A 411
ILE A 263
ILE A  54
 None
 1.29A 6mkeB-4k7cA:
undetectable
6mkeC-4k7cA:
undetectable		 6mkeB-4k7cA:
9.55
6mkeC-4k7cA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 4k7c AMINOPEPTIDASE C
(Lactobacillus
rhamnosus) 		4 / 6 LEU A 309
HIS A  81
TYR A 396
GLU A 384
 None
 0.90A 6pahA-4k7cA:
undetectable		 6pahA-4k7cA:
22.52