SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4k7d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		 4k7d E3 UBIQUITIN-PROTEIN
LIGASE PARKIN
(Rattus
norvegicus) 		5 / 12 ASN A 428
GLY A 430
MET A 192
LEU A 176
MET A 434
 None
 1.29A 3h52A-4k7dA:
undetectable		 3h52A-4k7dA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4k7d E3 UBIQUITIN-PROTEIN
LIGASE PARKIN
(Rattus
norvegicus) 		4 / 6 PHE A 208
HIS A 461
VAL A 465
PHE A 210
 None
ZN  A 508 (-3.3A)
None
None
 1.09A 4a97E-4k7dA:
undetectable		 4a97E-4k7dA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM5_A_CE3A301_2
(BETA-LACTAMASE
CTX-M-14)		 4k7d E3 UBIQUITIN-PROTEIN
LIGASE PARKIN
(Rattus
norvegicus) 		3 / 3 CYH A 238
PRO A 247
ASP A 262
 ZN  A 503 (-2.3A)
None
None
 0.99A 4pm5A-4k7dA:
undetectable		 4pm5A-4k7dA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4k7d E3 UBIQUITIN-PROTEIN
LIGASE PARKIN
(Rattus
norvegicus) 		3 / 3 VAL A 164
ALA A 172
PHE A 209
 None
 0.91A 4z4iA-4k7dA:
undetectable		 4z4iA-4k7dA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYI_A_NIZA805_1
(CATALASE-PEROXIDASE)		 4k7d E3 UBIQUITIN-PROTEIN
LIGASE PARKIN
(Rattus
norvegicus) 		4 / 5 ARG A 402
HIS A 257
ALA A 398
PRO A 237
 None
ZN  A 504 (-3.1A)
None
None
 1.27A 5syiA-4k7dA:
undetectable		 5syiA-4k7dA:
16.12