SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4k7k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_B_NCAB508_0
(NAD-DEPENDENT
DEACETYLASE 2)		 4k7k CATION EFFLUX SYSTEM
PROTEIN CUSC
(Escherichia
coli) 		4 / 5 GLN A 215
LEU A 218
TYR A 163
GLN A 237
 None
 1.45A 1yc2B-4k7kA:
undetectable
1yc2C-4k7kA:
undetectable		 1yc2B-4k7kA:
20.32
1yc2C-4k7kA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q8H_A_TF4A438_1
([PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1)		 4k7k CATION EFFLUX SYSTEM
PROTEIN CUSC
(Escherichia
coli) 		4 / 6 LEU A 273
TYR A 349
ILE A 325
ILE A 280
 None
 0.90A 2q8hA-4k7kA:
3.7		 2q8hA-4k7kA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SM2_A_478A126_2
(GAG-PRO-POL
POLYPROTEIN)		 4k7k CATION EFFLUX SYSTEM
PROTEIN CUSC
(Escherichia
coli) 		5 / 11 ALA A 300
VAL A 360
GLY A 254
ALA A 253
LEU A 364
 None
 1.01A 3sm2B-4k7kA:
undetectable		 3sm2B-4k7kA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_B_NCTB501_1
(CYTOCHROME P450 2A13)		 4k7k CATION EFFLUX SYSTEM
PROTEIN CUSC
(Escherichia
coli) 		4 / 8 PHE A 120
ALA A  70
LEU A 148
LEU A 147
 None
 0.83A 4ejgB-4k7kA:
undetectable		 4ejgB-4k7kA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_C_NCTC501_1
(CYTOCHROME P450 2A13)		 4k7k CATION EFFLUX SYSTEM
PROTEIN CUSC
(Escherichia
coli) 		4 / 7 PHE A 120
ALA A  70
LEU A 148
LEU A 147
 None
 0.85A 4ejgC-4k7kA:
undetectable		 4ejgC-4k7kA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_2
(ANCESTRAL STEROID
RECEPTOR 2)		 4k7k CATION EFFLUX SYSTEM
PROTEIN CUSC
(Escherichia
coli) 		4 / 8 ALA A 129
THR A  64
VAL A 144
PHE A 119
 None
 1.00A 4ltwA-4k7kA:
undetectable		 4ltwA-4k7kA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4k7k CATION EFFLUX SYSTEM
PROTEIN CUSC
(Escherichia
coli) 		3 / 3 ILE A 353
ASP A 265
ARG A 284
 None
 0.72A 4pstA-4k7kA:
undetectable		 4pstA-4k7kA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y28_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4k7k CATION EFFLUX SYSTEM
PROTEIN CUSC
(Escherichia
coli) 		5 / 9 PHE A  40
ARG A 263
ALA A 436
LEU A 437
GLY A 439
 None
 1.49A 4y28A-4k7kA:
1.5
4y28J-4k7kA:
undetectable		 4y28A-4k7kA:
19.20
4y28J-4k7kA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8R_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4k7k CATION EFFLUX SYSTEM
PROTEIN CUSC
(Escherichia
coli) 		5 / 9 PHE A  40
ARG A 263
ALA A 436
LEU A 437
GLY A 439
 None
 1.49A 5l8rA-4k7kA:
undetectable		 5l8rA-4k7kA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_B_SAMB901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 4k7k CATION EFFLUX SYSTEM
PROTEIN CUSC
(Escherichia
coli) 		5 / 12 LEU A 437
GLY A 440
HIS A 441
VAL A 152
ILE A  50
 None
 1.40A 6bxnB-4k7kA:
undetectable		 6bxnB-4k7kA:
22.00