SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4k81'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_B_DMEB996_1
(ACETYLCHOLINESTERASE)		 4k81 GROWTH FACTOR
RECEPTOR-BOUND
PROTEIN 14
(Homo
sapiens) 		4 / 6 GLU A 326
ILE A 254
TYR A 255
GLY A 269
 None
 1.03A 1maaB-4k81A:
undetectable
1maaD-4k81A:
undetectable		 1maaB-4k81A:
18.51
1maaD-4k81A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4k81 GROWTH FACTOR
RECEPTOR-BOUND
PROTEIN 14
(Homo
sapiens) 		3 / 3 VAL A 133
ALA A 130
HIS A 167
 None
 0.78A 1q23C-4k81A:
undetectable		 1q23C-4k81A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O01_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4k81 GROWTH FACTOR
RECEPTOR-BOUND
PROTEIN 14
(Homo
sapiens) 		4 / 8 PHE A 187
SER A 114
ARG A 120
LEU A 137
 None
 1.02A 2o01A-4k81A:
undetectable		 2o01A-4k81A:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 4k81 GROWTH FACTOR
RECEPTOR-BOUND
PROTEIN 14
(Homo
sapiens) 		4 / 6 THR A 331
ARG A 330
THR A 150
ASP A 146
 None
 1.13A 2okcB-4k81A:
undetectable		 2okcB-4k81A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1001_0
(ALDEHYDE
DEHYDROGENASE A)		 4k81 GROWTH FACTOR
RECEPTOR-BOUND
PROTEIN 14
(Homo
sapiens) 		4 / 7 LEU A 258
PHE A 279
ILE A 337
PHE A 308
 None
 0.87A 2opxA-4k81A:
undetectable		 2opxA-4k81A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_2
(GLUCOCORTICOID
RECEPTOR 2)		 4k81 GROWTH FACTOR
RECEPTOR-BOUND
PROTEIN 14
(Homo
sapiens) 		3 / 3 MET A 208
MET A 227
PHE A 203
 None
 1.12A 3gn8A-4k81A:
undetectable		 3gn8A-4k81A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_B_ZPCB1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4k81 GROWTH FACTOR
RECEPTOR-BOUND
PROTEIN 14
(Homo
sapiens) 		5 / 12 ILE A 110
GLU A 161
GLU A 117
TYR A 186
VAL A 133
 GOL  A 404 ( 4.3A)
None
None
None
None
 1.28A 4a97A-4k81A:
undetectable
4a97B-4k81A:
undetectable		 4a97A-4k81A:
21.45
4a97B-4k81A:
21.45