SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4k8f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXH_B_PACB1001_0
(PENICILLIN ACYLASE)		 4k8f TRANSCRIPTIONAL
REGULATOR, CRP/FNR
FAMILY
(Rhodospirillum
rubrum) 		4 / 7 MET A 108
PHE A  19
PHE A  98
ILE A   7
 None
None
HEM  A 300 (-4.6A)
None
 1.05A 1fxhA-4k8fA:
undetectable
1fxhB-4k8fA:
undetectable		 1fxhA-4k8fA:
18.66
1fxhB-4k8fA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PNL_B_PACB559_0
(PENICILLIN
AMIDOHYDROLASE)		 4k8f TRANSCRIPTIONAL
REGULATOR, CRP/FNR
FAMILY
(Rhodospirillum
rubrum) 		4 / 8 MET A 108
PHE A  19
PHE A  98
ILE A   7
 None
None
HEM  A 300 (-4.6A)
None
 1.05A 1pnlA-4k8fA:
undetectable
1pnlB-4k8fA:
undetectable		 1pnlA-4k8fA:
18.66
1pnlB-4k8fA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_B_BEZB1503_0
(RAS-RELATED PROTEIN
RAB-9A)		 4k8f TRANSCRIPTIONAL
REGULATOR, CRP/FNR
FAMILY
(Rhodospirillum
rubrum) 		4 / 6 VAL A  47
GLU A  86
LEU A  52
ARG A  51
 None
 1.14A 1s8fB-4k8fA:
undetectable		 1s8fB-4k8fA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4k8f TRANSCRIPTIONAL
REGULATOR, CRP/FNR
FAMILY
(Rhodospirillum
rubrum) 		4 / 7 PHE A  23
PHE A  19
LEU A 112
MET A 108
 None
None
HEM  A 300 (-4.5A)
None
 0.92A 4zdzA-4k8fA:
undetectable		 4zdzA-4k8fA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESJ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4k8f TRANSCRIPTIONAL
REGULATOR, CRP/FNR
FAMILY
(Rhodospirillum
rubrum) 		4 / 8 PHE A  23
PHE A  19
LEU A 112
MET A 108
 None
None
HEM  A 300 (-4.5A)
None
 0.90A 5esjA-4k8fA:
undetectable		 5esjA-4k8fA:
13.75