SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4k8y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		 4k8y KALLIKREIN-4
(Homo
sapiens) 		4 / 4 HIS A  48
LEU A 231
LEU A 212
LEU A  33
 None
 1.21A 1a4lD-4k8yA:
undetectable		 1a4lD-4k8yA:
21.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		 4k8y KALLIKREIN-4
(Homo
sapiens) 		5 / 9 ASP A 189
SER A 195
VAL A 213
GLY A 216
GLY A 226
 None
 0.44A 1bcuH-4k8yA:
17.4		 1bcuH-4k8yA:
35.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 4k8y KALLIKREIN-4
(Homo
sapiens) 		6 / 12 HIS A  57
ASP A 189
SER A 195
VAL A 213
GLY A 216
GLY A 226
 None
 0.57A 1etrH-4k8yA:
32.5		 1etrH-4k8yA:
32.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 4k8y KALLIKREIN-4
(Homo
sapiens) 		6 / 12 LEU A  99
ASP A 189
SER A 195
VAL A 213
GLY A 216
GLY A 226
 None
 0.86A 1etrH-4k8yA:
32.5		 1etrH-4k8yA:
32.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4k8y KALLIKREIN-4
(Homo
sapiens) 		6 / 8 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
 None
 0.41A 1f5lA-4k8yA:
15.2		 1f5lA-4k8yA:
33.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TNL_A_TPAA900_1
(TRYPSIN)		 4k8y KALLIKREIN-4
(Homo
sapiens) 		6 / 6 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
 None
 0.38A 1tnlA-4k8yA:
37.0		 1tnlA-4k8yA:
40.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 4k8y KALLIKREIN-4
(Homo
sapiens) 		6 / 6 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
 None
 0.39A 2otvA-4k8yA:
37.0		 2otvA-4k8yA:
40.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 4k8y KALLIKREIN-4
(Homo
sapiens) 		6 / 12 ASP A 189
SER A 195
VAL A 213
GLY A 216
GLY A 226
TYR A 228
 None
 0.42A 2p16A-4k8yA:
32.7		 2p16A-4k8yA:
29.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 4k8y KALLIKREIN-4
(Homo
sapiens) 		6 / 8 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
 None
 0.38A 2vinA-4k8yA:
16.2		 2vinA-4k8yA:
33.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 4k8y KALLIKREIN-4
(Homo
sapiens) 		6 / 12 ASP A 189
SER A 195
VAL A 213
GLY A 216
GLY A 226
TYR A 228
 None
 0.43A 2w26A-4k8yA:
12.5		 2w26A-4k8yA:
29.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		 4k8y KALLIKREIN-4
(Homo
sapiens) 		3 / 3 SER A 122
THR A 235
PHE A 181
 None
 0.69A 2x91A-4k8yA:
undetectable		 2x91A-4k8yA:
16.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)		 4k8y KALLIKREIN-4
(Homo
sapiens) 		6 / 11 HIS A  57
ASP A 189
SER A 190
SER A 195
GLY A 216
GLY A 226
 None
 0.43A 3gy3A-4k8yA:
36.6		 3gy3A-4k8yA:
40.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)		 4k8y KALLIKREIN-4
(Homo
sapiens) 		5 / 11 LEU A  99
ASP A 189
SER A 190
GLY A 216
GLY A 226
 None
 0.76A 3gy3A-4k8yA:
36.6		 3gy3A-4k8yA:
40.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		 4k8y KALLIKREIN-4
(Homo
sapiens) 		3 / 3 ASP A 102
ASN A  95
SER A 195
 None
 0.94A 3lslA-4k8yA:
undetectable
3lslD-4k8yA:
undetectable		 3lslA-4k8yA:
22.56
3lslD-4k8yA:
22.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 4k8y KALLIKREIN-4
(Homo
sapiens) 		5 / 6 SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
 None
 0.49A 3rxfA-4k8yA:
14.5		 3rxfA-4k8yA:
40.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		 4k8y KALLIKREIN-4
(Homo
sapiens) 		5 / 5 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 226
 None
 0.50A 3rxhA-4k8yA:
37.1		 3rxhA-4k8yA:
40.89