SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4k90'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP
EXTRACELLULAR
METALLOPROTEINASE
MEP
(Aspergillus
fumigatus;
Aspergillus
fumigatus) 		5 / 12 ALA B  48
ILE A 603
ASN A 599
LEU A 566
TYR B  45
 None
 1.13A 1dhfA-4k90B:
undetectable		 1dhfA-4k90B:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_B_FOLB187_0
(DIHYDROFOLATE
REDUCTASE)		 4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP
EXTRACELLULAR
METALLOPROTEINASE
MEP
(Aspergillus
fumigatus;
Aspergillus
fumigatus) 		5 / 12 ALA B  48
ILE A 603
ASN A 599
LEU A 566
TYR B  45
 None
 1.13A 1dhfB-4k90B:
undetectable		 1dhfB-4k90B:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DLS_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP
(Aspergillus
fumigatus) 		5 / 12 ALA B  48
ILE A 603
ASN A 599
LEU A 566
TYR B  45
 None
 1.12A 1dlsA-4k90B:
undetectable		 1dlsA-4k90B:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1869_0
(FPRA)		 4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP
(Aspergillus
fumigatus) 		4 / 4 ASP A 463
HIS A 429
ARG A 495
GLU A 459
 None
ZN  A 701 (-3.2A)
MLA  A 704 (-2.7A)
ZN  A 701 (-2.2A)
 1.03A 1lqtA-4k90A:
1.8		 1lqtA-4k90A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP
(Aspergillus
fumigatus) 		5 / 12 ILE A 603
LEU A 612
PHE A 607
LEU A 530
ILE A 587
 None
 1.15A 1rb2B-4k90A:
undetectable		 1rb2B-4k90A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		 4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP
(Aspergillus
fumigatus) 		5 / 8 GLU A 459
HIS A 429
HIS A 520
HIS A 433
GLU A 430
 ZN  A 701 (-2.2A)
ZN  A 701 (-3.2A)
MLA  A 704 (-3.6A)
ZN  A 701 (-3.2A)
MLA  A 704 (-3.7A)
 1.30A 1v7zA-4k90A:
undetectable		 1v7zA-4k90A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		 4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP
(Aspergillus
fumigatus) 		5 / 8 GLU A 459
HIS A 429
HIS A 520
HIS A 433
GLU A 430
 ZN  A 701 (-2.2A)
ZN  A 701 (-3.2A)
MLA  A 704 (-3.6A)
ZN  A 701 (-3.2A)
MLA  A 704 (-3.7A)
 1.31A 1v7zB-4k90A:
undetectable		 1v7zB-4k90A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		 4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP
(Aspergillus
fumigatus) 		5 / 8 GLU A 459
HIS A 429
HIS A 520
HIS A 433
GLU A 430
 ZN  A 701 (-2.2A)
ZN  A 701 (-3.2A)
MLA  A 704 (-3.6A)
ZN  A 701 (-3.2A)
MLA  A 704 (-3.7A)
 1.31A 1v7zC-4k90A:
undetectable		 1v7zC-4k90A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		 4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP
(Aspergillus
fumigatus) 		5 / 8 GLU A 459
HIS A 429
HIS A 520
HIS A 433
GLU A 430
 ZN  A 701 (-2.2A)
ZN  A 701 (-3.2A)
MLA  A 704 (-3.6A)
ZN  A 701 (-3.2A)
MLA  A 704 (-3.7A)
 1.31A 1v7zD-4k90A:
undetectable		 1v7zD-4k90A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		 4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP
(Aspergillus
fumigatus) 		5 / 8 GLU A 459
HIS A 429
HIS A 520
HIS A 433
GLU A 430
 ZN  A 701 (-2.2A)
ZN  A 701 (-3.2A)
MLA  A 704 (-3.6A)
ZN  A 701 (-3.2A)
MLA  A 704 (-3.7A)
 1.30A 1v7zE-4k90A:
undetectable		 1v7zE-4k90A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		 4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP
(Aspergillus
fumigatus) 		5 / 8 GLU A 459
HIS A 429
HIS A 520
HIS A 433
GLU A 430
 ZN  A 701 (-2.2A)
ZN  A 701 (-3.2A)
MLA  A 704 (-3.6A)
ZN  A 701 (-3.2A)
MLA  A 704 (-3.7A)
 1.32A 1v7zF-4k90A:
undetectable		 1v7zF-4k90A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP
(Aspergillus
fumigatus) 		5 / 12 ALA A 393
HIS A 429
GLU A 430
HIS A 433
GLU A 459
 MLA  A 704 (-4.4A)
ZN  A 701 (-3.2A)
MLA  A 704 (-3.7A)
ZN  A 701 (-3.2A)
ZN  A 701 (-2.2A)
 0.33A 2c6nA-4k90A:
7.9		 2c6nA-4k90A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_C_SAMC803_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP
(Aspergillus
fumigatus) 		5 / 11 GLU A 360
GLY A 374
LEU A 375
PRO A 443
ARG A 438
 None
None
None
None
CA  A 702 (-4.7A)
 1.42A 2h21C-4k90A:
undetectable		 2h21C-4k90A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_2
(MINERALOCORTICOID
RECEPTOR)		 4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP
(Aspergillus
fumigatus) 		4 / 5 LEU A 353
LEU A 356
LEU A 594
MET A 465
 None
 1.11A 2oaxF-4k90A:
undetectable		 2oaxF-4k90A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP
EXTRACELLULAR
METALLOPROTEINASE
MEP
(Aspergillus
fumigatus;
Aspergillus
fumigatus) 		3 / 3 ASN A 383
ARG A 407
ASP B 218
 None
 0.94A 2qe6A-4k90A:
undetectable		 2qe6A-4k90A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP
EXTRACELLULAR
METALLOPROTEINASE
MEP
(Aspergillus
fumigatus;
Aspergillus
fumigatus) 		3 / 3 ASN A 383
ARG A 407
ASP B 218
 None
 0.98A 2qe6B-4k90A:
undetectable		 2qe6B-4k90A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_0
(DIHYDROFOLATE
REDUCTASE)		 4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP
EXTRACELLULAR
METALLOPROTEINASE
MEP
(Aspergillus
fumigatus;
Aspergillus
fumigatus) 		5 / 12 ALA B  48
ILE A 603
ASN A 599
LEU A 566
TYR B  45
 None
 1.13A 2w3bB-4k90B:
undetectable		 2w3bB-4k90B:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRH_A_NIOA200_1
(PROTEIN HP0721)		 4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP
(Aspergillus
fumigatus) 		4 / 7 ILE A 428
THR A 432
MET A 564
LEU A 353
 None
 0.91A 2xrhA-4k90A:
undetectable		 2xrhA-4k90A:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZB7_A_NCAA901_0
(PROSTAGLANDIN
REDUCTASE 2)		 4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP
(Aspergillus
fumigatus) 		4 / 5 ILE A 428
MET A 568
LEU A 352
LEU A 353
 None
 1.17A 2zb7A-4k90A:
undetectable		 2zb7A-4k90A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		 4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP
(Aspergillus
fumigatus) 		5 / 8 GLU A 459
HIS A 429
HIS A 520
HIS A 433
GLU A 430
 ZN  A 701 (-2.2A)
ZN  A 701 (-3.2A)
MLA  A 704 (-3.6A)
ZN  A 701 (-3.2A)
MLA  A 704 (-3.7A)
 1.26A 3a6jA-4k90A:
undetectable		 3a6jA-4k90A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		 4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP
(Aspergillus
fumigatus) 		5 / 7 GLU A 459
HIS A 429
HIS A 520
HIS A 433
GLU A 430
 ZN  A 701 (-2.2A)
ZN  A 701 (-3.2A)
MLA  A 704 (-3.6A)
ZN  A 701 (-3.2A)
MLA  A 704 (-3.7A)
 1.24A 3a6jB-4k90A:
undetectable		 3a6jB-4k90A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		 4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP
(Aspergillus
fumigatus) 		5 / 8 GLU A 459
HIS A 429
HIS A 520
HIS A 433
GLU A 430
 ZN  A 701 (-2.2A)
ZN  A 701 (-3.2A)
MLA  A 704 (-3.6A)
ZN  A 701 (-3.2A)
MLA  A 704 (-3.7A)
 1.25A 3a6jC-4k90A:
undetectable		 3a6jC-4k90A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		 4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP
(Aspergillus
fumigatus) 		5 / 8 GLU A 459
HIS A 429
HIS A 520
HIS A 433
GLU A 430
 ZN  A 701 (-2.2A)
ZN  A 701 (-3.2A)
MLA  A 704 (-3.6A)
ZN  A 701 (-3.2A)
MLA  A 704 (-3.7A)
 1.26A 3a6jE-4k90A:
undetectable		 3a6jE-4k90A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		 4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP
(Aspergillus
fumigatus) 		5 / 8 GLU A 459
HIS A 429
HIS A 520
HIS A 433
GLU A 430
 ZN  A 701 (-2.2A)
ZN  A 701 (-3.2A)
MLA  A 704 (-3.6A)
ZN  A 701 (-3.2A)
MLA  A 704 (-3.7A)
 1.25A 3a6jF-4k90A:
undetectable		 3a6jF-4k90A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_B_NCAB302_0
(ADP-RIBOSYL CYCLASE
1)		 4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP
(Aspergillus
fumigatus) 		4 / 7 LEU A 449
TRP A 461
SER A 436
THR A 432
 None
 1.09A 3dzgB-4k90A:
undetectable		 3dzgB-4k90A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_1
(PROTEASE)		 4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP
(Aspergillus
fumigatus) 		4 / 8 GLY A 425
ILE A 426
PRO A 258
THR A 259
 None
MLA  A 704 ( 4.6A)
None
None
 0.74A 3el9A-4k90A:
undetectable		 3el9A-4k90A:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP
(Aspergillus
fumigatus) 		5 / 12 ALA A 297
GLY A 295
VAL A 380
MET A 406
ASN A 347
 None
 1.11A 3f8wA-4k90A:
undetectable		 3f8wA-4k90A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP
(Aspergillus
fumigatus) 		5 / 12 ALA A 297
GLY A 295
VAL A 380
MET A 406
ASN A 347
 None
 1.10A 3f8wC-4k90A:
undetectable		 3f8wC-4k90A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHX_B_PXLB313_1
(PYRIDOXAL KINASE)		 4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP
(Aspergillus
fumigatus) 		4 / 8 VAL B 118
VAL B  86
HIS B  74
VAL B 126
 None
 0.74A 3fhxB-4k90B:
undetectable		 3fhxB-4k90B:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_1
(REPRESSOR PROTEIN
MPHR(A))		 4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP
(Aspergillus
fumigatus) 		4 / 5 ASN A 370
ASN A 294
HIS A 350
ALA A 274
 None
 1.36A 3frqA-4k90A:
undetectable		 3frqA-4k90A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_1
(REPRESSOR PROTEIN
MPHR(A))		 4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP
(Aspergillus
fumigatus) 		4 / 7 ASN A 370
ASN A 294
HIS A 350
ALA A 274
 None
 1.36A 3frqB-4k90A:
undetectable		 3frqB-4k90A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS4_A_AZMA703_1
(CARBONIC ANHYDRASE 2)		 4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP
(Aspergillus
fumigatus) 		4 / 5 TRP A 270
HIS A 350
TRP A 279
ASP A 271
 None
 1.26A 3hs4A-4k90A:
0.0		 3hs4A-4k90A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB315_0
(UNCHARACTERIZED
PROTEIN)		 4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP
(Aspergillus
fumigatus) 		5 / 12 THR B 160
ILE B 236
ILE B 219
THR B 217
VAL B  32
 None
 1.37A 3ijdB-4k90B:
undetectable		 3ijdB-4k90B:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_A_ADNA300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP
(Aspergillus
fumigatus) 		5 / 11 ALA A 362
GLY B  93
ASP B  94
LEU A 439
ALA A 572
 None
 1.24A 3kw2A-4k90A:
undetectable		 3kw2A-4k90A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_B_ADNB300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP
(Aspergillus
fumigatus) 		5 / 11 ALA A 362
GLY B  93
ASP B  94
LEU A 439
ALA A 572
 None
 1.23A 3kw2B-4k90A:
undetectable		 3kw2B-4k90A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R55_A_PZAA598_0
(LACTOPEROXIDASE)		 4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP
(Aspergillus
fumigatus) 		3 / 3 GLU A 276
PHE A 277
GLN A 372
 None
 0.96A 3r55A-4k90A:
undetectable		 3r55A-4k90A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3N_A_DLUA398_1
(PFV INTEGRASE)		 4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP
(Aspergillus
fumigatus) 		4 / 8 ASP B  89
GLY A 441
PRO A 399
GLN A 402
 None
CA  A 703 ( 4.5A)
None
None
 1.03A 3s3nA-4k90B:
undetectable		 3s3nA-4k90B:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWR_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP
(Aspergillus
fumigatus) 		5 / 11 ALA A 396
ASP A 386
ASN A 394
GLY A 404
ILE A 381
 None
 1.36A 3vwrA-4k90A:
undetectable		 3vwrA-4k90A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_B_DVAB8_0
(VAL-GRAMICIDIN A)		 4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP
(Aspergillus
fumigatus) 		3 / 3 TRP A 270
VAL A 273
TRP A 279
 None
 1.23A 3zq8A-4k90A:
undetectable
3zq8B-4k90A:
undetectable		 3zq8A-4k90A:
3.83
3zq8B-4k90A:
3.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP
(Aspergillus
fumigatus) 		3 / 3 TYR A 409
MET A 408
ILE A 428
 None
 0.74A 4c8bB-4k90A:
undetectable		 4c8bB-4k90A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP
(Aspergillus
fumigatus) 		5 / 12 ALA B  48
ILE A 603
ASN A 599
LEU A 566
TYR B  45
 None
 1.06A 4gh8A-4k90B:
undetectable		 4gh8A-4k90B:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_2
(ANCESTRAL STEROID
RECEPTOR 2)		 4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP
(Aspergillus
fumigatus) 		4 / 8 MET A 465
ALA A 466
PHE A 395
THR A 397
 None
 1.00A 4ltwA-4k90A:
undetectable		 4ltwA-4k90A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0O_A_URFA303_1
(RRNA N-GLYCOSIDASE)		 4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP
(Aspergillus
fumigatus) 		4 / 5 TYR A 287
ASN A 293
TYR A 379
ILE A 296
 None
 1.25A 4o0oA-4k90A:
undetectable		 4o0oA-4k90A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCU_A_SAMA603_0
(CYSTATHIONINE
BETA-SYNTHASE)		 4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP
(Aspergillus
fumigatus) 		4 / 7 PHE A 464
ASP A 463
THR A 432
ILE A 428
 None
 1.03A 4pcuA-4k90A:
undetectable		 4pcuA-4k90A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_2
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP
(Aspergillus
fumigatus) 		4 / 4 VAL B 126
ILE B  78
ASN B 117
VAL B  46
 None
 1.14A 5ajqA-4k90B:
undetectable		 5ajqA-4k90B:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP
(Aspergillus
fumigatus) 		4 / 5 ALA A 337
TYR A 334
PRO A 258
GLY A 492
 None
 1.01A 5eslA-4k90A:
undetectable		 5eslA-4k90A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)		 4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP
EXTRACELLULAR
METALLOPROTEINASE
MEP
(Aspergillus
fumigatus;
Aspergillus
fumigatus) 		4 / 7 ASP A 569
GLY B  96
GLY B  93
HIS B  99
 None
 1.02A 5n9xA-4k90A:
undetectable		 5n9xA-4k90A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP
(Aspergillus
fumigatus) 		5 / 9 THR A 524
GLY A 523
ALA A 527
LEU A 516
SER A 512
 None
 1.26A 5vw4A-4k90A:
undetectable		 5vw4A-4k90A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_0
(MRNA CAPPING ENZYME
P5)		 4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP
EXTRACELLULAR
METALLOPROTEINASE
MEP
(Aspergillus
fumigatus;
Aspergillus
fumigatus) 		5 / 12 LEU A 562
GLY A 597
HIS A 541
THR A 592
PHE B 127
 None
None
None
None
GOL  B 305 (-4.2A)
 1.33A 5x6yA-4k90A:
undetectable		 5x6yA-4k90A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6M_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP
(Aspergillus
fumigatus) 		5 / 11 ILE A 603
LEU A 612
PHE A 607
LEU A 530
ILE A 587
 None
 1.04A 5z6mA-4k90A:
undetectable		 5z6mA-4k90A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXM_A_SAMA402_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP
(Aspergillus
fumigatus) 		5 / 12 GLY A 613
VAL A 567
ARG A 584
ILE A 587
ASP A 585
 None
None
None
None
NAG  B 302 ( 3.0A)
 1.25A 6bxmA-4k90A:
undetectable		 6bxmA-4k90A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_C_GLYC713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP
(Aspergillus
fumigatus) 		3 / 3 GLN A 298
TYR A 307
ASN A 383
 None
 1.07A 6dwdC-4k90A:
undetectable		 6dwdC-4k90A:
19.55