SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4k92'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_B_KANB559_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 4k92 CLIP-ASSOCIATING
PROTEIN 1
(Homo
sapiens) 		4 / 8 GLU A 505
LYS A 508
ASP A 298
GLU A 466
 None
 0.91A 1knyA-4k92A:
undetectable
1knyB-4k92A:
undetectable		 1knyA-4k92A:
23.37
1knyB-4k92A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_D_T3D602_1
(TRANSTHYRETIN)		 4k92 CLIP-ASSOCIATING
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 369
GLU A 329
LEU A 366
LYS A 347
LEU A 351
 None
 1.11A 1sn5B-4k92A:
undetectable
1sn5D-4k92A:
undetectable		 1sn5B-4k92A:
19.06
1sn5D-4k92A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_D_T3D602_1
(TRANSTHYRETIN)		 4k92 CLIP-ASSOCIATING
PROTEIN 1
(Homo
sapiens) 		5 / 12 LYS A 347
LEU A 351
LEU A 369
GLU A 329
LEU A 366
 None
 1.13A 1sn5B-4k92A:
undetectable
1sn5D-4k92A:
undetectable		 1sn5B-4k92A:
19.06
1sn5D-4k92A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U1J_A_C2FA773_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 4k92 CLIP-ASSOCIATING
PROTEIN 1
(Homo
sapiens) 		4 / 8 ARG A 462
ASN A 452
SER A 455
VAL A 460
 None
 1.11A 1u1jA-4k92A:
undetectable		 1u1jA-4k92A:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_A_ADNA433_2
(ADENOSYLHOMOCYSTEINA
SE)		 4k92 CLIP-ASSOCIATING
PROTEIN 1
(Homo
sapiens) 		3 / 3 THR A 477
GLU A 520
HIS A 514
 None
 0.87A 1xwfA-4k92A:
undetectable		 1xwfA-4k92A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_B_ADNB433_2
(ADENOSYLHOMOCYSTEINA
SE)		 4k92 CLIP-ASSOCIATING
PROTEIN 1
(Homo
sapiens) 		3 / 3 THR A 477
GLU A 520
HIS A 514
 None
 0.86A 1xwfB-4k92A:
undetectable		 1xwfB-4k92A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_C_ADNC433_2
(ADENOSYLHOMOCYSTEINA
SE)		 4k92 CLIP-ASSOCIATING
PROTEIN 1
(Homo
sapiens) 		3 / 3 THR A 477
GLU A 520
HIS A 514
 None
 0.86A 1xwfC-4k92A:
undetectable		 1xwfC-4k92A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_D_ADND433_2
(ADENOSYLHOMOCYSTEINA
SE)		 4k92 CLIP-ASSOCIATING
PROTEIN 1
(Homo
sapiens) 		3 / 3 THR A 477
GLU A 520
HIS A 514
 None
 0.86A 1xwfD-4k92A:
undetectable		 1xwfD-4k92A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_A_J01A500_1
(ORF12)		 4k92 CLIP-ASSOCIATING
PROTEIN 1
(Homo
sapiens) 		4 / 8 VAL A 309
LEU A 320
GLY A 355
ALA A 356
 None
 0.90A 2xfsA-4k92A:
undetectable		 2xfsA-4k92A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1436_1
(ORF12)		 4k92 CLIP-ASSOCIATING
PROTEIN 1
(Homo
sapiens) 		4 / 8 VAL A 309
LEU A 320
GLY A 355
ALA A 356
 None
 0.92A 2xh9A-4k92A:
undetectable		 2xh9A-4k92A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA504_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 4k92 CLIP-ASSOCIATING
PROTEIN 1
(Homo
sapiens) 		4 / 8 PHE A 306
GLY A 393
LEU A 435
ILE A 436
 None
 0.82A 4em2A-4k92A:
undetectable		 4em2A-4k92A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4k92 CLIP-ASSOCIATING
PROTEIN 1
(Homo
sapiens) 		4 / 5 GLU A 339
GLU A 387
THR A 391
LEU A 331
 None
 1.22A 5hm8A-4k92A:
undetectable		 5hm8A-4k92A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_B_ADNB501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4k92 CLIP-ASSOCIATING
PROTEIN 1
(Homo
sapiens) 		4 / 5 GLU A 339
GLU A 387
THR A 391
LEU A 331
 None
 1.23A 5hm8B-4k92A:
undetectable		 5hm8B-4k92A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_C_ADNC501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4k92 CLIP-ASSOCIATING
PROTEIN 1
(Homo
sapiens) 		4 / 5 GLU A 339
GLU A 387
THR A 391
LEU A 331
 None
 1.23A 5hm8C-4k92A:
undetectable		 5hm8C-4k92A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_D_ADND501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4k92 CLIP-ASSOCIATING
PROTEIN 1
(Homo
sapiens) 		4 / 5 GLU A 339
GLU A 387
THR A 391
LEU A 331
 None
 1.23A 5hm8D-4k92A:
undetectable		 5hm8D-4k92A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_E_ADNE501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4k92 CLIP-ASSOCIATING
PROTEIN 1
(Homo
sapiens) 		4 / 5 GLU A 339
GLU A 387
THR A 391
LEU A 331
 None
 1.23A 5hm8E-4k92A:
undetectable		 5hm8E-4k92A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_F_ADNF501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4k92 CLIP-ASSOCIATING
PROTEIN 1
(Homo
sapiens) 		4 / 5 GLU A 339
GLU A 387
THR A 391
LEU A 331
 None
 1.22A 5hm8F-4k92A:
undetectable		 5hm8F-4k92A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_H_ADNH501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4k92 CLIP-ASSOCIATING
PROTEIN 1
(Homo
sapiens) 		4 / 5 GLU A 339
GLU A 387
THR A 391
LEU A 331
 None
 1.23A 5hm8H-4k92A:
undetectable		 5hm8H-4k92A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_D_ADND502_2
(-)		 4k92 CLIP-ASSOCIATING
PROTEIN 1
(Homo
sapiens) 		4 / 5 ILE A 410
THR A 413
THR A 391
LEU A 331
 None
 0.93A 6f3mD-4k92A:
undetectable		 6f3mD-4k92A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_E_AM2E301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4k92 CLIP-ASSOCIATING
PROTEIN 1
(Homo
sapiens) 		4 / 7 THR A 413
ARG A 341
HIS A 336
ASP A 379
 None
 1.38A 6mn4E-4k92A:
undetectable		 6mn4E-4k92A:
20.82