SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4k9d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_G_CCSG149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 4k9d GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Brugia
malayi) 		4 / 7 ASN A 321
TYR A 325
ASN A 160
TYR A 319
 NAD  A 401 (-3.9A)
NAD  A 401 (-3.6A)
None
None
 0.93A 1dssG-4k9dA:
53.5		 1dssG-4k9dA:
69.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_G_CCSG149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 4k9d GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Brugia
malayi) 		7 / 7 SER A 156
THR A 158
ASN A 160
CYH A 161
TYR A 319
ASN A 321
TYR A 325
 None
None
None
None
None
NAD  A 401 (-3.9A)
NAD  A 401 (-3.6A)
 0.13A 1dssG-4k9dA:
53.5		 1dssG-4k9dA:
69.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_R_CCSR149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 4k9d GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Brugia
malayi) 		4 / 8 ASN A 321
TYR A 325
ASN A 160
TYR A 319
 NAD  A 401 (-3.9A)
NAD  A 401 (-3.6A)
None
None
 0.92A 1dssR-4k9dA:
53.4		 1dssR-4k9dA:
69.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_R_CCSR149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 4k9d GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Brugia
malayi) 		8 / 8 SER A 156
THR A 158
ASN A 160
CYH A 161
HIS A 184
TYR A 319
ASN A 321
TYR A 325
 None
None
None
None
None
None
NAD  A 401 (-3.9A)
NAD  A 401 (-3.6A)
 0.32A 1dssR-4k9dA:
53.4		 1dssR-4k9dA:
69.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4003_1
(SERUM ALBUMIN)		 4k9d GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Brugia
malayi) 		5 / 9 ILE A 175
VAL A 222
GLY A 223
ALA A 166
LEU A 162
 None
 1.07A 1e7bA-4k9dA:
undetectable		 1e7bA-4k9dA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_3
(HIV-1 PROTEASE)		 4k9d GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Brugia
malayi) 		5 / 12 ALA A  22
VAL A   6
ILE A 333
ILE A  14
VAL A  33
 None
None
None
NAD  A 401 (-3.9A)
None
 0.96A 1hxbB-4k9dA:
undetectable		 1hxbB-4k9dA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_A_ACTA1107_0
(C5A PEPTIDASE)		 4k9d GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Brugia
malayi) 		4 / 5 LEU A 254
GLY A 174
HIS A 170
ILE A 169
 None
 0.73A 1xf1A-4k9dA:
2.2		 1xf1A-4k9dA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_B_ACTB1108_0
(C5A PEPTIDASE)		 4k9d GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Brugia
malayi) 		4 / 6 LEU A 254
GLY A 174
HIS A 170
ILE A 169
 None
 0.69A 1xf1B-4k9dA:
undetectable		 1xf1B-4k9dA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 4k9d GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Brugia
malayi) 		5 / 12 GLY A 217
SER A 156
LEU A 200
HIS A 184
TYR A 319
 None
 1.29A 1zgyA-4k9dA:
undetectable		 1zgyA-4k9dA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HCJ_B_TACB888_1
(PROTEIN CHAIN
ELONGATION FACTOR
EF-TU)		 4k9d GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Brugia
malayi) 		4 / 4 THR A 109
SER A 129
ASP A 131
PRO A 133
 None
None
None
EDO  A 402 (-4.6A)
 1.45A 2hcjA-4k9dA:
0.0
2hcjB-4k9dA:
0.3		 2hcjA-4k9dA:
7.78
2hcjB-4k9dA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_B_TACB1888_1
(ELONGATION FACTOR
EF-TU)		 4k9d GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Brugia
malayi) 		4 / 5 THR A 109
SER A 129
ASP A 131
PRO A 133
 None
None
None
EDO  A 402 (-4.6A)
 1.41A 2hdnA-4k9dA:
undetectable
2hdnB-4k9dA:
undetectable
2hdnD-4k9dA:
undetectable		 2hdnA-4k9dA:
7.78
2hdnB-4k9dA:
23.45
2hdnD-4k9dA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_D_TACD2888_1
(ELONGATION FACTOR
EF-TU)		 4k9d GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Brugia
malayi) 		4 / 5 THR A 109
SER A 129
ASP A 131
PRO A 133
 None
None
None
EDO  A 402 (-4.6A)
 1.42A 2hdnB-4k9dA:
undetectable
2hdnC-4k9dA:
undetectable
2hdnD-4k9dA:
undetectable		 2hdnB-4k9dA:
23.45
2hdnC-4k9dA:
7.78
2hdnD-4k9dA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 4k9d GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Brugia
malayi) 		4 / 5 PHE A  56
PHE A  47
PHE A  11
VAL A  23
 None
 1.07A 2lh6A-4k9dA:
undetectable		 2lh6A-4k9dA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_0
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 4k9d GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Brugia
malayi) 		5 / 12 ALA A  22
GLY A   7
TYR A  98
ILE A  89
ALA A  32
 None
 0.95A 2plwA-4k9dA:
3.5		 2plwA-4k9dA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_B_BEZB261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 4k9d GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Brugia
malayi) 		4 / 8 HIS A 150
ASN A 149
ILE A 152
TYR A 144
 None
 1.45A 3ccfB-4k9dA:
4.2		 3ccfB-4k9dA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_D_TMQD614_1
(DHFR-TS)		 4k9d GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Brugia
malayi) 		5 / 10 VAL A  30
ALA A  96
ILE A  89
PRO A  36
ILE A  78
 None
None
None
NAD  A 401 (-4.4A)
None
 1.26A 3clbD-4k9dA:
undetectable		 3clbD-4k9dA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_A_GW6A1_1
(GLUCOCORTICOID
RECEPTOR)		 4k9d GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Brugia
malayi) 		5 / 12 ASN A  34
GLY A  10
MET A  43
LEU A  19
LEU A  67
 NAD  A 401 (-4.5A)
NAD  A 401 (-3.4A)
None
None
None
 1.44A 3cldA-4k9dA:
undetectable		 3cldA-4k9dA:
22.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DMT_C_CCSC166_0
(GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL)		 4k9d GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Brugia
malayi) 		4 / 8 ASN A 321
TYR A 325
ASN A 160
TYR A 319
 NAD  A 401 (-3.9A)
NAD  A 401 (-3.6A)
None
None
 0.95A 3dmtC-4k9dA:
50.0		 3dmtC-4k9dA:
52.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DMT_C_CCSC166_0
(GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL)		 4k9d GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Brugia
malayi) 		8 / 8 SER A 156
THR A 158
ASN A 160
CYH A 161
HIS A 184
TYR A 319
ASN A 321
TYR A 325
 None
None
None
None
None
None
NAD  A 401 (-3.9A)
NAD  A 401 (-3.6A)
 0.27A 3dmtC-4k9dA:
50.0		 3dmtC-4k9dA:
52.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKX_B_1UNB201_2
(PROTEASE)		 4k9d GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Brugia
malayi) 		5 / 11 ALA A  22
VAL A   6
ILE A 333
ILE A  14
VAL A  33
 None
None
None
NAD  A 401 (-3.9A)
None
 0.97A 3ekxB-4k9dA:
undetectable		 3ekxB-4k9dA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4k9d GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Brugia
malayi) 		5 / 12 TYR A 319
ASN A 230
GLY A 217
ALA A 218
GLY A 223
 None
 0.92A 3hs6B-4k9dA:
undetectable		 3hs6B-4k9dA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_1
(HIV-1 PROTEASE)		 4k9d GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Brugia
malayi) 		5 / 12 ALA A  22
VAL A   6
ILE A 333
ILE A  14
VAL A  33
 None
None
None
NAD  A 401 (-3.9A)
None
 0.96A 3k4vC-4k9dA:
undetectable		 3k4vC-4k9dA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MWS_B_017B201_2
(HIV-1 PROTEASE)		 4k9d GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Brugia
malayi) 		5 / 12 ALA A  22
VAL A   6
ILE A 333
ILE A  14
VAL A  33
 None
None
None
NAD  A 401 (-3.9A)
None
 0.98A 3mwsB-4k9dA:
undetectable		 3mwsB-4k9dA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_1
(PROTEASE)		 4k9d GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Brugia
malayi) 		5 / 10 ALA A  22
VAL A   6
ILE A 333
ILE A  14
VAL A  33
 None
None
None
NAD  A 401 (-3.9A)
None
 0.98A 3nu6A-4k9dA:
undetectable		 3nu6A-4k9dA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_2
(PROTEASE)		 4k9d GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Brugia
malayi) 		5 / 12 ALA A  22
VAL A   6
ILE A 333
ILE A  14
VAL A  33
 None
None
None
NAD  A 401 (-3.9A)
None
 0.94A 3tkgD-4k9dA:
undetectable		 3tkgD-4k9dA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB513_1
(HEMOLYTIC LECTIN
CEL-III)		 4k9d GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Brugia
malayi) 		4 / 6 THR A 103
ASN A   9
ASP A  35
ILE A  38
 NAD  A 401 (-4.1A)
NAD  A 401 (-3.4A)
NAD  A 401 (-2.8A)
None
 1.44A 3w9tB-4k9dA:
undetectable		 3w9tB-4k9dA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4k9d GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Brugia
malayi) 		5 / 12 TYR A 319
ASN A 230
GLY A 217
ALA A 218
GLY A 223
 None
 0.85A 4e1gA-4k9dA:
undetectable		 4e1gA-4k9dA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NNR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2)		 4k9d GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Brugia
malayi) 		5 / 12 ASP A  29
VAL A  33
ILE A   8
ILE A 333
PRO A  86
 None
 1.17A 4nnrA-4k9dA:
undetectable
4nnrB-4k9dA:
undetectable		 4nnrA-4k9dA:
18.15
4nnrB-4k9dA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 4k9d GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Brugia
malayi) 		4 / 6 ASP A 203
ALA A 207
THR A 189
THR A 187
 None
 1.48A 4z4cA-4k9dA:
3.4		 4z4cA-4k9dA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERS_A_ACTA803_0
(GEPHYRIN)		 4k9d GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Brugia
malayi) 		3 / 3 THR A 159
ALA A 155
ASN A 160
 None
 0.56A 5ersA-4k9dA:
2.0		 5ersA-4k9dA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_B_ADNB401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 4k9d GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Brugia
malayi) 		4 / 8 LYS A 167
ALA A 163
ASP A 171
ASN A 230
 None
 0.98A 5mvsB-4k9dA:
3.5		 5mvsB-4k9dA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 4k9d GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Brugia
malayi) 		4 / 6 PHE A 238
VAL A 183
ALA A 237
THR A 158
 None
 1.07A 5t7bA-4k9dA:
2.2		 5t7bA-4k9dA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4k9d GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Brugia
malayi) 		4 / 7 THR A 187
ARG A 239
ASP A 203
LEU A 200
 None
 1.19A 5uxcA-4k9dA:
undetectable		 5uxcA-4k9dA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIL_B_TPVB201_0
(HIV-1 PROTEASE)		 4k9d GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Brugia
malayi) 		5 / 12 ALA A  22
VAL A   6
ILE A 333
ILE A  14
VAL A  33
 None
None
None
NAD  A 401 (-3.9A)
None
 0.85A 6dilA-4k9dA:
undetectable		 6dilA-4k9dA:
14.14