SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4k9q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AKD_A_CAMA420_0
(CYTOCHROME P450CAM)
4k9q BENZOYLFORMATE
DECARBOXYLASE

(Polynucleobacter
necessarius)
5 / 11 THR A 441
VAL A 408
GLY A 409
VAL A  21
VAL A  42
None
1.22A 1akdA-4k9qA:
undetectable
1akdA-4k9qA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_B_ESTB354_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)
4k9q BENZOYLFORMATE
DECARBOXYLASE

(Polynucleobacter
necessarius)
4 / 8 SER A 417
VAL A 416
LEU A  57
VAL A  21
None
1.04A 1fduB-4k9qA:
undetectable
1fduB-4k9qA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)
4k9q BENZOYLFORMATE
DECARBOXYLASE

(Polynucleobacter
necessarius)
4 / 4 ILE A 376
LEU A 504
VAL A 522
ILE A 524
None
0.85A 1fm6D-4k9qA:
undetectable
1fm6D-4k9qA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)
4k9q BENZOYLFORMATE
DECARBOXYLASE

(Polynucleobacter
necessarius)
4 / 8 PRO A 132
ASP A 162
SER A 157
THR A 111
None
1.13A 1p7lC-4k9qA:
undetectable
1p7lC-4k9qA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)
4k9q BENZOYLFORMATE
DECARBOXYLASE

(Polynucleobacter
necessarius)
4 / 8 PRO A 132
ASP A 162
SER A 157
THR A 111
None
1.14A 1p7lD-4k9qA:
undetectable
1p7lD-4k9qA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)
4k9q BENZOYLFORMATE
DECARBOXYLASE

(Polynucleobacter
necessarius)
4 / 8 PRO A 132
ASP A 162
SER A 157
THR A 111
None
1.12A 1rg9A-4k9qA:
undetectable
1rg9A-4k9qA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)
4k9q BENZOYLFORMATE
DECARBOXYLASE

(Polynucleobacter
necessarius)
4 / 8 PRO A 132
ASP A 162
SER A 157
THR A 111
None
1.14A 1rg9B-4k9qA:
undetectable
1rg9B-4k9qA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)
4k9q BENZOYLFORMATE
DECARBOXYLASE

(Polynucleobacter
necessarius)
4 / 8 PRO A 132
ASP A 162
SER A 157
THR A 111
None
1.12A 1rg9C-4k9qA:
undetectable
1rg9C-4k9qA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)
4k9q BENZOYLFORMATE
DECARBOXYLASE

(Polynucleobacter
necessarius)
4 / 8 PRO A 132
ASP A 162
SER A 157
THR A 111
None
1.14A 1rg9D-4k9qA:
undetectable
1rg9D-4k9qA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRD_A_MIYA2001_1
(ACRB)
4k9q BENZOYLFORMATE
DECARBOXYLASE

(Polynucleobacter
necessarius)
5 / 9 GLN A 433
PHE A 432
GLY A 428
ASN A 456
VAL A 521
None
None
TPP  A 602 (-3.4A)
MG  A 601 ( 2.7A)
None
1.37A 2drdA-4k9qA:
undetectable
2drdA-4k9qA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_A_NCAA1501_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)
4k9q BENZOYLFORMATE
DECARBOXYLASE

(Polynucleobacter
necessarius)
4 / 7 ARG A 210
ALA A 231
ARG A 276
ASP A 207
None
1.13A 2e5dA-4k9qA:
3.2
2e5dB-4k9qA:
undetectable
2e5dA-4k9qA:
22.28
2e5dB-4k9qA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_B_NCAB1502_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)
4k9q BENZOYLFORMATE
DECARBOXYLASE

(Polynucleobacter
necessarius)
4 / 7 ASP A 207
ARG A 210
ALA A 231
ARG A 276
None
1.16A 2e5dA-4k9qA:
3.3
2e5dB-4k9qA:
undetectable
2e5dA-4k9qA:
22.28
2e5dB-4k9qA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)
4k9q BENZOYLFORMATE
DECARBOXYLASE

(Polynucleobacter
necessarius)
4 / 6 LEU A 311
SER A 296
ASP A 297
ASP A 298
None
1.11A 2j2pE-4k9qA:
undetectable
2j2pF-4k9qA:
undetectable
2j2pE-4k9qA:
18.41
2j2pF-4k9qA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA2_0
(FERROCHELATASE)
4k9q BENZOYLFORMATE
DECARBOXYLASE

(Polynucleobacter
necessarius)
4 / 8 LEU A  12
PRO A  91
SER A  58
VAL A 154
None
1.12A 2qd2A-4k9qA:
3.1
2qd2A-4k9qA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA2_0
(FERROCHELATASE)
4k9q BENZOYLFORMATE
DECARBOXYLASE

(Polynucleobacter
necessarius)
4 / 8 LEU A  15
PRO A  91
SER A  58
VAL A 154
None
1.20A 2qd2A-4k9qA:
3.1
2qd2A-4k9qA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_D_D16D609_1
(THYMIDYLATE SYNTHASE)
4k9q BENZOYLFORMATE
DECARBOXYLASE

(Polynucleobacter
necessarius)
5 / 9 PHE A 465
ILE A 461
ASP A 478
LEU A 477
THR A 471
None
TPP  A 602 (-3.9A)
None
None
None
1.50A 2tsrD-4k9qA:
undetectable
2tsrD-4k9qA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_A_ASDA1224_1
(GLUTATHIONE
S-TRANSFERASE A3)
4k9q BENZOYLFORMATE
DECARBOXYLASE

(Polynucleobacter
necessarius)
4 / 7 PRO A 119
ALA A 115
LEU A  75
ALA A  96
None
1.09A 2vcvA-4k9qA:
undetectable
2vcvA-4k9qA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)
4k9q BENZOYLFORMATE
DECARBOXYLASE

(Polynucleobacter
necessarius)
4 / 6 PRO A 119
ALA A 115
LEU A  75
ALA A  96
None
0.96A 2vcvB-4k9qA:
undetectable
2vcvB-4k9qA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_L_ASDL1224_1
(GLUTATHIONE
S-TRANSFERASE A3)
4k9q BENZOYLFORMATE
DECARBOXYLASE

(Polynucleobacter
necessarius)
4 / 7 PRO A 119
ALA A 115
LEU A  75
ALA A  96
None
0.97A 2vcvL-4k9qA:
undetectable
2vcvL-4k9qA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)
4k9q BENZOYLFORMATE
DECARBOXYLASE

(Polynucleobacter
necessarius)
3 / 3 TYR A 434
GLU A 372
THR A  84
TPP  A 602 (-4.3A)
None
None
1.00A 2y7hB-4k9qA:
undetectable
2y7hB-4k9qA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_A_DIFA1_1
(TRANSTHYRETIN)
4k9q BENZOYLFORMATE
DECARBOXYLASE

(Polynucleobacter
necessarius)
4 / 6 LEU A 531
ALA A 466
LEU A 468
THR A 471
None
1.02A 3cfqA-4k9qA:
undetectable
3cfqA-4k9qA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKK_A_SAMA301_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)
4k9q BENZOYLFORMATE
DECARBOXYLASE

(Polynucleobacter
necessarius)
5 / 12 GLY A  97
ALA A  78
MET A  79
LEU A 156
GLU A 128
None
0.89A 3ckkA-4k9qA:
2.7
3ckkA-4k9qA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_A_ACTA700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)
4k9q BENZOYLFORMATE
DECARBOXYLASE

(Polynucleobacter
necessarius)
4 / 6 GLY A  72
GLY A  76
MET A  79
ASN A 112
None
0.91A 3e9rA-4k9qA:
undetectable
3e9rA-4k9qA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_C_ACTC700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)
4k9q BENZOYLFORMATE
DECARBOXYLASE

(Polynucleobacter
necessarius)
4 / 6 GLY A  72
GLY A  76
MET A  79
ASN A 112
None
0.90A 3e9rC-4k9qA:
undetectable
3e9rC-4k9qA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)
4k9q BENZOYLFORMATE
DECARBOXYLASE

(Polynucleobacter
necessarius)
5 / 10 ILE A  66
VAL A 135
GLY A 137
VAL A 154
LEU A  15
None
1.20A 3em0A-4k9qA:
undetectable
3em0A-4k9qA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GGU_B_017B201_1
(PROTEASE)
4k9q BENZOYLFORMATE
DECARBOXYLASE

(Polynucleobacter
necessarius)
5 / 12 ALA A 411
VAL A 368
GLY A  56
THR A 425
VAL A 423
None
1.00A 3gguA-4k9qA:
undetectable
3gguA-4k9qA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_A_CAMA423_0
(CYTOCHROME P450)
4k9q BENZOYLFORMATE
DECARBOXYLASE

(Polynucleobacter
necessarius)
5 / 10 THR A 441
THR A  19
LEU A 412
GLY A 409
VAL A  65
None
1.24A 3lxiA-4k9qA:
undetectable
3lxiA-4k9qA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_B_CAMB423_0
(CYTOCHROME P450)
4k9q BENZOYLFORMATE
DECARBOXYLASE

(Polynucleobacter
necessarius)
5 / 11 THR A 441
THR A  19
LEU A 412
GLY A 409
VAL A  65
None
1.21A 3lxiB-4k9qA:
undetectable
3lxiB-4k9qA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_A_VORA506_1
(CHOLESTEROL
24-HYDROXYLASE)
4k9q BENZOYLFORMATE
DECARBOXYLASE

(Polynucleobacter
necessarius)
5 / 9 LEU A 410
SER A  60
ILE A  53
ALA A  54
ALA A  85
None
1.21A 3mdtA-4k9qA:
undetectable
3mdtA-4k9qA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_B_T44B128_1
(TRANSTHYRETIN)
4k9q BENZOYLFORMATE
DECARBOXYLASE

(Polynucleobacter
necessarius)
4 / 7 ALA A 466
LEU A 468
THR A 471
VAL A 474
None
1.06A 3ozkB-4k9qA:
undetectable
3ozkB-4k9qA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_B_CAMB1420_0
(CYTOCHROME P450)
4k9q BENZOYLFORMATE
DECARBOXYLASE

(Polynucleobacter
necessarius)
5 / 10 THR A 441
THR A  19
LEU A 412
GLY A 409
VAL A  65
None
1.28A 4c9nB-4k9qA:
undetectable
4c9nB-4k9qA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_A_CAMA423_0
(CYTOCHROME P450)
4k9q BENZOYLFORMATE
DECARBOXYLASE

(Polynucleobacter
necessarius)
5 / 9 THR A 441
THR A  19
LEU A 412
GLY A 409
VAL A  65
None
1.29A 4c9pA-4k9qA:
undetectable
4c9pA-4k9qA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_B_CAMB423_0
(CYTOCHROME P450)
4k9q BENZOYLFORMATE
DECARBOXYLASE

(Polynucleobacter
necessarius)
5 / 10 THR A 441
THR A  19
LEU A 412
GLY A 409
VAL A  65
None
1.27A 4c9pB-4k9qA:
undetectable
4c9pB-4k9qA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_C_SVRC301_1
(NUCLEOCAPSID PROTEIN)
4k9q BENZOYLFORMATE
DECARBOXYLASE

(Polynucleobacter
necessarius)
4 / 8 ASN A 199
ARG A 329
PRO A 287
ILE A 267
None
0.97A 4j4vC-4k9qA:
undetectable
4j4vC-4k9qA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)
4k9q BENZOYLFORMATE
DECARBOXYLASE

(Polynucleobacter
necessarius)
4 / 7 LEU A  12
PRO A  91
SER A  58
VAL A 154
None
1.20A 4klrA-4k9qA:
2.6
4klrA-4k9qA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)
4k9q BENZOYLFORMATE
DECARBOXYLASE

(Polynucleobacter
necessarius)
4 / 7 LEU A  15
PRO A  91
SER A  58
VAL A 154
None
1.21A 4klrA-4k9qA:
2.6
4klrA-4k9qA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)
4k9q BENZOYLFORMATE
DECARBOXYLASE

(Polynucleobacter
necessarius)
5 / 12 THR A 447
GLY A  56
GLY A 413
THR A  84
ALA A 406
None
0.92A 4uckA-4k9qA:
undetectable
4uckA-4k9qA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_A_29SA601_1
(ESTROGEN RECEPTOR)
4k9q BENZOYLFORMATE
DECARBOXYLASE

(Polynucleobacter
necessarius)
5 / 12 ALA A  96
GLU A  28
LEU A 158
LEU A 110
PRO A 129
None
1.23A 4xi3A-4k9qA:
undetectable
4xi3A-4k9qA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_1
(ESTROGEN RECEPTOR)
4k9q BENZOYLFORMATE
DECARBOXYLASE

(Polynucleobacter
necessarius)
5 / 12 ALA A  96
GLU A  28
LEU A 158
LEU A 110
PRO A 129
None
1.21A 4xi3D-4k9qA:
undetectable
4xi3D-4k9qA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)
4k9q BENZOYLFORMATE
DECARBOXYLASE

(Polynucleobacter
necessarius)
3 / 4 ARG A 419
GLY A 418
GLU A 414
None
0.52A 4z2dB-4k9qA:
undetectable
4z2dC-4k9qA:
undetectable
4z2dB-4k9qA:
23.49
4z2dC-4k9qA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP4_A_CAMA422_0
(CYTOCHROME P450CAM)
4k9q BENZOYLFORMATE
DECARBOXYLASE

(Polynucleobacter
necessarius)
5 / 9 THR A 441
VAL A 408
GLY A 409
VAL A  21
VAL A  42
None
1.11A 5cp4A-4k9qA:
undetectable
5cp4A-4k9qA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_A_ACTA404_0
(L-LYSINE
3-HYDROXYLASE)
4k9q BENZOYLFORMATE
DECARBOXYLASE

(Polynucleobacter
necessarius)
4 / 6 ILE A 367
LEU A 512
VAL A 424
SER A 363
None
1.29A 6f6jA-4k9qA:
undetectable
6f6jA-4k9qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA807_0
(GEPHYRIN)
4k9q BENZOYLFORMATE
DECARBOXYLASE

(Polynucleobacter
necessarius)
4 / 4 PRO A 232
LEU A 257
VAL A 274
ARG A 276
None
1.36A 6fgdA-4k9qA:
2.6
6fgdA-4k9qA:
22.92