SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4k9s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4k9s GDSL-LIKE
LIPASE/ACYLHYDROLASE
FAMILY PROTEIN
(Neisseria
meningitidis) 		4 / 5 THR A 186
THR A 179
GLU A 210
HIS A 208
 None
 1.28A 1d4fB-4k9sA:
undetectable		 1d4fB-4k9sA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_K_AG2K671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4k9s GDSL-LIKE
LIPASE/ACYLHYDROLASE
FAMILY PROTEIN
(Neisseria
meningitidis) 		4 / 8 GLN A 327
LEU A 323
LEU A 309
GLY A 367
 None
 0.90A 2qqcH-4k9sA:
undetectable
2qqcK-4k9sA:
undetectable		 2qqcH-4k9sA:
15.93
2qqcK-4k9sA:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_D_TOPD200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4k9s GDSL-LIKE
LIPASE/ACYLHYDROLASE
FAMILY PROTEIN
(Neisseria
meningitidis) 		5 / 9 MET A  58
ALA A  52
VAL A 390
ILE A  74
LEU A  95
 None
 1.35A 3fl9D-4k9sA:
undetectable		 3fl9D-4k9sA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 4k9s GDSL-LIKE
LIPASE/ACYLHYDROLASE
FAMILY PROTEIN
(Neisseria
meningitidis) 		5 / 10 MET A  58
ALA A  52
VAL A 390
ILE A  74
LEU A  95
 None
 1.16A 3jw3A-4k9sA:
undetectable		 3jw3A-4k9sA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 4k9s GDSL-LIKE
LIPASE/ACYLHYDROLASE
FAMILY PROTEIN
(Neisseria
meningitidis) 		5 / 9 MET A  58
ALA A  52
VAL A 390
ILE A  74
LEU A  95
 None
 1.22A 3jw3B-4k9sA:
undetectable		 3jw3B-4k9sA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_1
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 4k9s GDSL-LIKE
LIPASE/ACYLHYDROLASE
FAMILY PROTEIN
(Neisseria
meningitidis) 		3 / 3 ARG A 289
ASP A 279
GLN A 238
 None
 0.79A 3lcvB-4k9sA:
undetectable		 3lcvB-4k9sA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_A_CP6A201_1
(DIHYDROFOLATE
REDUCTASE)		 4k9s GDSL-LIKE
LIPASE/ACYLHYDROLASE
FAMILY PROTEIN
(Neisseria
meningitidis) 		5 / 10 ALA A 231
ASP A  85
LEU A 155
ILE A 104
THR A  88
 None
 1.28A 4km0A-4k9sA:
undetectable		 4km0A-4k9sA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA2)		 4k9s GDSL-LIKE
LIPASE/ACYLHYDROLASE
FAMILY PROTEIN
(Neisseria
meningitidis) 		4 / 6 SER A 128
GLY A  84
ASP A  85
GLY A 233
 None
 1.04A 4koeA-4k9sA:
undetectable
4koeB-4k9sA:
undetectable
4koeC-4k9sA:
3.7		 4koeA-4k9sA:
22.58
4koeB-4k9sA:
22.58
4koeC-4k9sA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4k9s GDSL-LIKE
LIPASE/ACYLHYDROLASE
FAMILY PROTEIN
(Neisseria
meningitidis) 		5 / 12 VAL A 288
ALA A 258
LEU A 260
THR A 339
ALA A 297
 None
 1.17A 4x1kA-4k9sA:
3.0
4x1kB-4k9sA:
2.4		 4x1kA-4k9sA:
22.38
4x1kB-4k9sA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4k9s GDSL-LIKE
LIPASE/ACYLHYDROLASE
FAMILY PROTEIN
(Neisseria
meningitidis) 		5 / 9 MET A 354
GLY A 304
ALA A 347
MET A 348
ILE A 303
 None
 1.19A 5i3cA-4k9sA:
2.2		 5i3cA-4k9sA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_B_AC2B301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4k9s GDSL-LIKE
LIPASE/ACYLHYDROLASE
FAMILY PROTEIN
(Neisseria
meningitidis) 		5 / 10 MET A 354
GLY A 304
ALA A 347
MET A 348
ILE A 303
 None
 1.16A 5i3cB-4k9sA:
2.5		 5i3cB-4k9sA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGJ_A_X6XA402_1
(PREDICTED
ACETYLTRANSFERASE)		 4k9s GDSL-LIKE
LIPASE/ACYLHYDROLASE
FAMILY PROTEIN
(Neisseria
meningitidis) 		4 / 5 ARG A  73
TRP A 106
GLU A 221
ASP A 198
 None
 1.29A 5kgjA-4k9sA:
undetectable		 5kgjA-4k9sA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 4k9s GDSL-LIKE
LIPASE/ACYLHYDROLASE
FAMILY PROTEIN
(Neisseria
meningitidis) 		5 / 12 LEU A 253
ALA A 258
LEU A  91
SER A 230
LEU A 386
 None
 1.11A 5ljeA-4k9sA:
undetectable		 5ljeA-4k9sA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 4k9s GDSL-LIKE
LIPASE/ACYLHYDROLASE
FAMILY PROTEIN
(Neisseria
meningitidis) 		5 / 12 VAL A 120
HIS A 122
PHE A 217
THR A 130
GLY A  84
 None
 1.12A 5m54E-4k9sA:
4.4		 5m54E-4k9sA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 4k9s GDSL-LIKE
LIPASE/ACYLHYDROLASE
FAMILY PROTEIN
(Neisseria
meningitidis) 		5 / 12 ASP A  85
HIS A 122
SER A 158
ARG A  92
GLY A 105
 None
 1.18A 5m5cB-4k9sA:
5.3		 5m5cB-4k9sA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_1
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 4k9s GDSL-LIKE
LIPASE/ACYLHYDROLASE
FAMILY PROTEIN
(Neisseria
meningitidis) 		4 / 5 GLY A  84
ASP A  85
MET A 117
GLN A  96
 None
 1.20A 5ubbA-4k9sA:
undetectable		 5ubbA-4k9sA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		 4k9s GDSL-LIKE
LIPASE/ACYLHYDROLASE
FAMILY PROTEIN
(Neisseria
meningitidis) 		4 / 6 ALA A 393
SER A 392
ALA A  52
SER A  53
 None
 0.83A 6bocA-4k9sA:
undetectable
6bocB-4k9sA:
undetectable
6bocC-4k9sA:
undetectable
6bocD-4k9sA:
undetectable		 6bocA-4k9sA:
5.88
6bocB-4k9sA:
5.88
6bocC-4k9sA:
5.88
6bocD-4k9sA:
5.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_ACTA405_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4k9s GDSL-LIKE
LIPASE/ACYLHYDROLASE
FAMILY PROTEIN
(Neisseria
meningitidis) 		4 / 6 THR A  71
PRO A 223
GLN A 165
ARG A 166
 None
 1.41A 6ef6A-4k9sA:
undetectable		 6ef6A-4k9sA:
23.42