SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4k9z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_A_TOPA200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4k9z PUTATIVE
THIOL-DISULFIDE
OXIDOREDUCTASE
(Bacteroides
vulgatus) 		5 / 10 ALA A  27
ALA A 121
ILE A 122
LEU A  54
PHE A  30
 None
 1.17A 3fl9A-4k9zA:
undetectable		 3fl9A-4k9zA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_K_KANK301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4k9z PUTATIVE
THIOL-DISULFIDE
OXIDOREDUCTASE
(Bacteroides
vulgatus) 		4 / 8 ASP A 113
ASP A  44
ASP A  29
GLU A  31
 None
 1.01A 4gkhC-4k9zA:
undetectable
4gkhK-4k9zA:
undetectable		 4gkhC-4k9zA:
20.07
4gkhK-4k9zA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4k9z PUTATIVE
THIOL-DISULFIDE
OXIDOREDUCTASE
(Bacteroides
vulgatus) 		4 / 8 ASP A 113
ASP A  44
ASP A  29
GLU A  31
 None
 1.02A 4gkiE-4k9zA:
undetectable
4gkiG-4k9zA:
undetectable		 4gkiE-4k9zA:
20.07
4gkiG-4k9zA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4k9z PUTATIVE
THIOL-DISULFIDE
OXIDOREDUCTASE
(Bacteroides
vulgatus) 		4 / 5 PRO A  26
GLY A  24
ASP A  44
ASP A 134
 None
 1.04A 4n48B-4k9zA:
undetectable		 4n48B-4k9zA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EUM_B_ACTB603_0
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)		 4k9z PUTATIVE
THIOL-DISULFIDE
OXIDOREDUCTASE
(Bacteroides
vulgatus) 		4 / 4 ALA A 140
ASN A 139
ARG A 127
ILE A 129
 None
 1.49A 5eumB-4k9zA:
undetectable		 5eumB-4k9zA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_A_ACTA703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 4k9z PUTATIVE
THIOL-DISULFIDE
OXIDOREDUCTASE
(Bacteroides
vulgatus) 		4 / 6 ARG A 144
ALA A  68
PRO A 145
PHE A 128
 None
 1.40A 5odqA-4k9zA:
undetectable		 5odqA-4k9zA:
12.80