SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ka8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZ4_A_BEZA784_0
(MALT REGULATORY
PROTEIN)		 4ka8 OLIGOPEPTIDASE A
(Arabidopsis
thaliana) 		4 / 6 TRP A 718
LEU A 722
LEU A 602
PRO A 603
 GOL  A 805 (-3.6A)
GOL  A 805 ( 4.8A)
None
None
 1.28A 1hz4A-4ka8A:
undetectable		 1hz4A-4ka8A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4ka8 OLIGOPEPTIDASE A
(Arabidopsis
thaliana) 		7 / 12 GLN A 653
THR A 568
HIS A 571
GLU A 572
HIS A 575
HIS A 703
TYR A 713
 None
None
ZN  A 801 (-3.3A)
ZN  A 801 ( 4.6A)
ZN  A 801 (-3.3A)
None
None
 1.24A 1j36A-4ka8A:
20.8		 1j36A-4ka8A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4ka8 OLIGOPEPTIDASE A
(Arabidopsis
thaliana) 		8 / 12 THR A 568
HIS A 571
GLU A 572
HIS A 575
GLU A 601
HIS A 703
TYR A 713
TYR A 716
 None
ZN  A 801 (-3.3A)
ZN  A 801 ( 4.6A)
ZN  A 801 (-3.3A)
ZN  A 801 (-2.1A)
None
None
None
 0.37A 1j36A-4ka8A:
20.8		 1j36A-4ka8A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4ka8 OLIGOPEPTIDASE A
(Arabidopsis
thaliana) 		7 / 12 GLN A 653
THR A 568
HIS A 571
GLU A 572
HIS A 575
HIS A 703
TYR A 713
 None
None
ZN  A 801 (-3.3A)
ZN  A 801 ( 4.6A)
ZN  A 801 (-3.3A)
None
None
 1.24A 1j36B-4ka8A:
20.7		 1j36B-4ka8A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4ka8 OLIGOPEPTIDASE A
(Arabidopsis
thaliana) 		8 / 12 THR A 568
HIS A 571
GLU A 572
HIS A 575
GLU A 601
HIS A 703
TYR A 713
TYR A 716
 None
ZN  A 801 (-3.3A)
ZN  A 801 ( 4.6A)
ZN  A 801 (-3.3A)
ZN  A 801 (-2.1A)
None
None
None
 0.38A 1j36B-4ka8A:
20.7		 1j36B-4ka8A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_A_X8ZA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4ka8 OLIGOPEPTIDASE A
(Arabidopsis
thaliana) 		7 / 11 GLN A 653
HIS A 571
GLU A 572
HIS A 575
HIS A 703
TYR A 713
TYR A 716
 None
ZN  A 801 (-3.3A)
ZN  A 801 ( 4.6A)
ZN  A 801 (-3.3A)
None
None
None
 1.14A 1j37A-4ka8A:
20.8		 1j37A-4ka8A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_A_X8ZA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4ka8 OLIGOPEPTIDASE A
(Arabidopsis
thaliana) 		7 / 11 HIS A 571
GLU A 572
HIS A 575
GLU A 601
HIS A 703
TYR A 713
TYR A 716
 ZN  A 801 (-3.3A)
ZN  A 801 ( 4.6A)
ZN  A 801 (-3.3A)
ZN  A 801 (-2.1A)
None
None
None
 0.39A 1j37A-4ka8A:
20.8		 1j37A-4ka8A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_B_X8ZB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4ka8 OLIGOPEPTIDASE A
(Arabidopsis
thaliana) 		7 / 11 GLN A 653
HIS A 571
GLU A 572
HIS A 575
HIS A 703
TYR A 713
TYR A 716
 None
ZN  A 801 (-3.3A)
ZN  A 801 ( 4.6A)
ZN  A 801 (-3.3A)
None
None
None
 1.14A 1j37B-4ka8A:
20.7		 1j37B-4ka8A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_B_X8ZB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4ka8 OLIGOPEPTIDASE A
(Arabidopsis
thaliana) 		7 / 11 HIS A 571
GLU A 572
HIS A 575
GLU A 601
HIS A 703
TYR A 713
TYR A 716
 ZN  A 801 (-3.3A)
ZN  A 801 ( 4.6A)
ZN  A 801 (-3.3A)
ZN  A 801 (-2.1A)
None
None
None
 0.40A 1j37B-4ka8A:
20.7		 1j37B-4ka8A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4ka8 OLIGOPEPTIDASE A
(Arabidopsis
thaliana) 		6 / 12 GLN A 653
HIS A 571
GLU A 572
HIS A 575
HIS A 703
TYR A 713
 None
ZN  A 801 (-3.3A)
ZN  A 801 ( 4.6A)
ZN  A 801 (-3.3A)
None
None
 1.13A 1o86A-4ka8A:
21.5		 1o86A-4ka8A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4ka8 OLIGOPEPTIDASE A
(Arabidopsis
thaliana) 		7 / 12 HIS A 571
GLU A 572
HIS A 575
GLU A 601
HIS A 703
TYR A 713
TYR A 716
 ZN  A 801 (-3.3A)
ZN  A 801 ( 4.6A)
ZN  A 801 (-3.3A)
ZN  A 801 (-2.1A)
None
None
None
 0.36A 1o86A-4ka8A:
21.5		 1o86A-4ka8A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_B_RBFB596_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 4ka8 OLIGOPEPTIDASE A
(Arabidopsis
thaliana) 		5 / 11 GLU A 436
TYR A 443
LEU A 450
ILE A 445
ASP A 444
 None
 1.38A 1t6zB-4ka8A:
undetectable		 1t6zB-4ka8A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		 4ka8 OLIGOPEPTIDASE A
(Arabidopsis
thaliana) 		4 / 8 GLU A 601
HIS A 571
HIS A 575
GLU A 572
 ZN  A 801 (-2.1A)
ZN  A 801 (-3.3A)
ZN  A 801 (-3.3A)
ZN  A 801 ( 4.6A)
 0.85A 1v7zA-4ka8A:
undetectable		 1v7zA-4ka8A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		 4ka8 OLIGOPEPTIDASE A
(Arabidopsis
thaliana) 		4 / 8 GLU A 601
HIS A 571
HIS A 575
GLU A 572
 ZN  A 801 (-2.1A)
ZN  A 801 (-3.3A)
ZN  A 801 (-3.3A)
ZN  A 801 ( 4.6A)
 0.86A 1v7zB-4ka8A:
undetectable		 1v7zB-4ka8A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		 4ka8 OLIGOPEPTIDASE A
(Arabidopsis
thaliana) 		4 / 8 GLU A 601
HIS A 571
HIS A 575
GLU A 572
 ZN  A 801 (-2.1A)
ZN  A 801 (-3.3A)
ZN  A 801 (-3.3A)
ZN  A 801 ( 4.6A)
 0.86A 1v7zC-4ka8A:
undetectable		 1v7zC-4ka8A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		 4ka8 OLIGOPEPTIDASE A
(Arabidopsis
thaliana) 		4 / 8 GLU A 601
HIS A 571
HIS A 575
GLU A 572
 ZN  A 801 (-2.1A)
ZN  A 801 (-3.3A)
ZN  A 801 (-3.3A)
ZN  A 801 ( 4.6A)
 0.88A 1v7zD-4ka8A:
undetectable		 1v7zD-4ka8A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		 4ka8 OLIGOPEPTIDASE A
(Arabidopsis
thaliana) 		4 / 8 GLU A 601
HIS A 571
HIS A 575
GLU A 572
 ZN  A 801 (-2.1A)
ZN  A 801 (-3.3A)
ZN  A 801 (-3.3A)
ZN  A 801 ( 4.6A)
 0.88A 1v7zE-4ka8A:
undetectable		 1v7zE-4ka8A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		 4ka8 OLIGOPEPTIDASE A
(Arabidopsis
thaliana) 		4 / 8 GLU A 601
HIS A 571
HIS A 575
GLU A 572
 ZN  A 801 (-2.1A)
ZN  A 801 (-3.3A)
ZN  A 801 (-3.3A)
ZN  A 801 ( 4.6A)
 0.87A 1v7zF-4ka8A:
undetectable		 1v7zF-4ka8A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_1
(RETINOIC ACID
RECEPTOR, BETA)		 4ka8 OLIGOPEPTIDASE A
(Arabidopsis
thaliana) 		6 / 12 ALA A 710
LEU A 663
SER A 715
PHE A 701
LEU A 698
LEU A 359
 None
 1.30A 1xdkF-4ka8A:
undetectable		 1xdkF-4ka8A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1217_1
(LIPOPROTEIN LPPX)		 4ka8 OLIGOPEPTIDASE A
(Arabidopsis
thaliana) 		4 / 4 VAL A 543
LEU A 100
ILE A 164
LEU A 167
 None
 0.93A 2byoA-4ka8A:
undetectable		 2byoA-4ka8A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 4ka8 OLIGOPEPTIDASE A
(Arabidopsis
thaliana) 		8 / 12 ALA A 520
HIS A 571
GLU A 572
HIS A 575
GLU A 601
HIS A 703
TYR A 713
TYR A 716
 None
ZN  A 801 (-3.3A)
ZN  A 801 ( 4.6A)
ZN  A 801 (-3.3A)
ZN  A 801 (-2.1A)
None
None
None
 0.33A 2c6nA-4ka8A:
20.6		 2c6nA-4ka8A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 4ka8 OLIGOPEPTIDASE A
(Arabidopsis
thaliana) 		7 / 12 GLN A 653
ALA A 520
HIS A 571
GLU A 572
HIS A 575
HIS A 703
TYR A 713
 None
None
ZN  A 801 (-3.3A)
ZN  A 801 ( 4.6A)
ZN  A 801 (-3.3A)
None
None
 1.17A 2c6nA-4ka8A:
20.6		 2c6nA-4ka8A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 4ka8 OLIGOPEPTIDASE A
(Arabidopsis
thaliana) 		6 / 12 GLN A 653
HIS A 571
GLU A 572
HIS A 575
HIS A 703
TYR A 713
 None
ZN  A 801 (-3.3A)
ZN  A 801 ( 4.6A)
ZN  A 801 (-3.3A)
None
None
 1.19A 2c6nB-4ka8A:
20.6		 2c6nB-4ka8A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 4ka8 OLIGOPEPTIDASE A
(Arabidopsis
thaliana) 		7 / 12 HIS A 571
GLU A 572
HIS A 575
GLU A 601
HIS A 703
TYR A 713
TYR A 716
 ZN  A 801 (-3.3A)
ZN  A 801 ( 4.6A)
ZN  A 801 (-3.3A)
ZN  A 801 (-2.1A)
None
None
None
 0.42A 2c6nB-4ka8A:
20.6		 2c6nB-4ka8A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ECP_A_ACRA992_1
(MALTODEXTRIN
PHOSPHORYLASE)		 4ka8 OLIGOPEPTIDASE A
(Arabidopsis
thaliana) 		5 / 10 LEU A 341
ARG A 652
ASP A 695
ARG A 343
ALA A 317
 None
 1.47A 2ecpA-4ka8A:
undetectable		 2ecpA-4ka8A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_A_SAMA301_0
(YCGJ)		 4ka8 OLIGOPEPTIDASE A
(Arabidopsis
thaliana) 		5 / 12 GLY A 756
GLY A 591
ALA A 754
THR A 751
GLU A 767
 None
 1.06A 2gluA-4ka8A:
undetectable		 2gluA-4ka8A:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		 4ka8 OLIGOPEPTIDASE A
(Arabidopsis
thaliana) 		4 / 8 THR A 568
HIS A 571
GLU A 572
HIS A 575
 None
ZN  A 801 (-3.3A)
ZN  A 801 ( 4.6A)
ZN  A 801 (-3.3A)
 0.24A 2jihB-4ka8A:
3.0		 2jihB-4ka8A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2O_B_DHIB24_0
(INSULIN B CHAIN)		 4ka8 OLIGOPEPTIDASE A
(Arabidopsis
thaliana) 		4 / 6 GLY A 518
PRO A 513
LYS A 269
THR A 268
 None
 1.20A 2m2oB-4ka8A:
undetectable		 2m2oB-4ka8A:
4.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O01_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4ka8 OLIGOPEPTIDASE A
(Arabidopsis
thaliana) 		4 / 8 PHE A 748
ARG A 749
ALA A 754
LEU A 753
 None
 1.02A 2o01A-4ka8A:
undetectable		 2o01A-4ka8A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA509_0
(CHORISMATE SYNTHASE)		 4ka8 OLIGOPEPTIDASE A
(Arabidopsis
thaliana) 		3 / 3 ARG A 490
GLN A 550
PRO A 509
 None
 0.90A 2qhfA-4ka8A:
undetectable		 2qhfA-4ka8A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_G_BEZG1222_0
(PEROXIREDOXIN 6.)		 4ka8 OLIGOPEPTIDASE A
(Arabidopsis
thaliana) 		4 / 8 THR A 551
PRO A 552
ALA A 288
PRO A 318
 None
 1.15A 2v41G-4ka8A:
undetectable
2v41H-4ka8A:
undetectable		 2v41G-4ka8A:
15.13
2v41H-4ka8A:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8Z_A_X8ZA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4ka8 OLIGOPEPTIDASE A
(Arabidopsis
thaliana) 		6 / 11 GLN A 653
HIS A 571
GLU A 572
HIS A 575
HIS A 703
TYR A 713
 None
ZN  A 801 (-3.3A)
ZN  A 801 ( 4.6A)
ZN  A 801 (-3.3A)
None
None
 1.11A 2x8zA-4ka8A:
20.8		 2x8zA-4ka8A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8Z_A_X8ZA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4ka8 OLIGOPEPTIDASE A
(Arabidopsis
thaliana) 		7 / 11 HIS A 571
GLU A 572
HIS A 575
GLU A 601
HIS A 703
TYR A 713
TYR A 716
 ZN  A 801 (-3.3A)
ZN  A 801 ( 4.6A)
ZN  A 801 (-3.3A)
ZN  A 801 (-2.1A)
None
None
None
 0.31A 2x8zA-4ka8A:
20.8		 2x8zA-4ka8A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4ka8 OLIGOPEPTIDASE A
(Arabidopsis
thaliana) 		6 / 12 GLN A 653
HIS A 571
GLU A 572
HIS A 575
HIS A 703
TYR A 713
 None
ZN  A 801 (-3.3A)
ZN  A 801 ( 4.6A)
ZN  A 801 (-3.3A)
None
None
 1.15A 2x91A-4ka8A:
20.8		 2x91A-4ka8A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4ka8 OLIGOPEPTIDASE A
(Arabidopsis
thaliana) 		7 / 12 HIS A 571
GLU A 572
HIS A 575
GLU A 601
HIS A 703
TYR A 713
TYR A 716
 ZN  A 801 (-3.3A)
ZN  A 801 ( 4.6A)
ZN  A 801 (-3.3A)
ZN  A 801 (-2.1A)
None
None
None
 0.35A 2x91A-4ka8A:
20.8		 2x91A-4ka8A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		 4ka8 OLIGOPEPTIDASE A
(Arabidopsis
thaliana) 		4 / 8 GLU A 601
HIS A 571
HIS A 575
GLU A 572
 ZN  A 801 (-2.1A)
ZN  A 801 (-3.3A)
ZN  A 801 (-3.3A)
ZN  A 801 ( 4.6A)
 0.85A 3a6jA-4ka8A:
undetectable		 3a6jA-4ka8A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		 4ka8 OLIGOPEPTIDASE A
(Arabidopsis
thaliana) 		4 / 7 GLU A 601
HIS A 571
HIS A 575
GLU A 572
 ZN  A 801 (-2.1A)
ZN  A 801 (-3.3A)
ZN  A 801 (-3.3A)
ZN  A 801 ( 4.6A)
 0.82A 3a6jB-4ka8A:
undetectable		 3a6jB-4ka8A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		 4ka8 OLIGOPEPTIDASE A
(Arabidopsis
thaliana) 		4 / 8 GLU A 601
HIS A 571
HIS A 575
GLU A 572
 ZN  A 801 (-2.1A)
ZN  A 801 (-3.3A)
ZN  A 801 (-3.3A)
ZN  A 801 ( 4.6A)
 0.83A 3a6jC-4ka8A:
undetectable		 3a6jC-4ka8A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		 4ka8 OLIGOPEPTIDASE A
(Arabidopsis
thaliana) 		4 / 8 GLU A 601
HIS A 571
HIS A 575
GLU A 572
 ZN  A 801 (-2.1A)
ZN  A 801 (-3.3A)
ZN  A 801 (-3.3A)
ZN  A 801 ( 4.6A)
 0.86A 3a6jE-4ka8A:
undetectable		 3a6jE-4ka8A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		 4ka8 OLIGOPEPTIDASE A
(Arabidopsis
thaliana) 		4 / 8 GLU A 601
HIS A 571
HIS A 575
GLU A 572
 ZN  A 801 (-2.1A)
ZN  A 801 (-3.3A)
ZN  A 801 (-3.3A)
ZN  A 801 ( 4.6A)
 0.82A 3a6jF-4ka8A:
undetectable		 3a6jF-4ka8A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4ka8 OLIGOPEPTIDASE A
(Arabidopsis
thaliana) 		4 / 5 ARG A 645
GLN A 325
PHE A 433
LEU A 411
 None
 1.25A 3ablC-4ka8A:
4.2
3ablJ-4ka8A:
undetectable		 3ablC-4ka8A:
16.02
3ablJ-4ka8A:
7.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_DXCC576_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 4ka8 OLIGOPEPTIDASE A
(Arabidopsis
thaliana) 		4 / 8 PRO A 199
ALA A 203
ALA A 206
PRO A 141
 None
 0.64A 3dtuC-4ka8A:
1.9
3dtuD-4ka8A:
undetectable		 3dtuC-4ka8A:
22.05
3dtuD-4ka8A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA424_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4ka8 OLIGOPEPTIDASE A
(Arabidopsis
thaliana) 		4 / 8 LEU A 176
PRO A  99
GLY A 120
PRO A 119
 None
 1.15A 3hcrA-4ka8A:
undetectable		 3hcrA-4ka8A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4ka8 OLIGOPEPTIDASE A
(Arabidopsis
thaliana) 		4 / 5 LEU A 470
ARG A 747
ILE A 752
PHE A 748
 None
 1.09A 3ln1D-4ka8A:
undetectable		 3ln1D-4ka8A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 4ka8 OLIGOPEPTIDASE A
(Arabidopsis
thaliana) 		4 / 5 HIS A 326
THR A 432
GLU A 440
ASP A 444
 None
 1.24A 3tm4A-4ka8A:
undetectable		 3tm4A-4ka8A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 4ka8 OLIGOPEPTIDASE A
(Arabidopsis
thaliana) 		4 / 5 HIS A 326
THR A 432
GLU A 440
ASP A 444
 None
 1.26A 3tm4B-4ka8A:
undetectable		 3tm4B-4ka8A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VFJ_A_ACTA410_0
(MALTOSE-BINDING
PERIPLASMIC PROTEIN,
C-TERMINAL FUSED BY
CYS-LYS-D-ALA-D-ALA)		 4ka8 OLIGOPEPTIDASE A
(Arabidopsis
thaliana) 		4 / 4 LYS A 273
ALA A 331
GLU A 280
LEU A 332
 None
 1.42A 3vfjA-4ka8A:
undetectable		 3vfjA-4ka8A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C2P_A_X8ZA709_1
(ANGIOTENSIN-CONVERTI
NG ENZYME)		 4ka8 OLIGOPEPTIDASE A
(Arabidopsis
thaliana) 		6 / 11 GLN A 653
HIS A 571
GLU A 572
HIS A 575
HIS A 703
TYR A 713
 None
ZN  A 801 (-3.3A)
ZN  A 801 ( 4.6A)
ZN  A 801 (-3.3A)
None
None
 1.12A 4c2pA-4ka8A:
21.1		 4c2pA-4ka8A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C2P_A_X8ZA709_1
(ANGIOTENSIN-CONVERTI
NG ENZYME)		 4ka8 OLIGOPEPTIDASE A
(Arabidopsis
thaliana) 		7 / 11 HIS A 571
GLU A 572
HIS A 575
GLU A 601
HIS A 703
TYR A 713
TYR A 716
 ZN  A 801 (-3.3A)
ZN  A 801 ( 4.6A)
ZN  A 801 (-3.3A)
ZN  A 801 (-2.1A)
None
None
None
 0.46A 4c2pA-4ka8A:
21.1		 4c2pA-4ka8A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_A_TESA503_1
(CYTOCHROME P450
MONOOXYGENASE)		 4ka8 OLIGOPEPTIDASE A
(Arabidopsis
thaliana) 		6 / 12 PHE A 606
ALA A 726
ALA A 729
THR A 744
VAL A 741
LEU A 735
 None
 1.48A 4j6dA-4ka8A:
undetectable		 4j6dA-4ka8A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA506_0
(RNA POLYMERASE
3D-POL)		 4ka8 OLIGOPEPTIDASE A
(Arabidopsis
thaliana) 		3 / 3 VAL A 668
GLY A 670
LYS A 360
 None
 0.78A 4k50A-4ka8A:
undetectable		 4k50A-4ka8A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE504_0
(RNA POLYMERASE
3D-POL)		 4ka8 OLIGOPEPTIDASE A
(Arabidopsis
thaliana) 		3 / 3 VAL A 668
GLY A 670
LYS A 360
 None
 0.75A 4k50E-4ka8A:
1.8		 4k50E-4ka8A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI504_0
(RNA POLYMERASE
3D-POL)		 4ka8 OLIGOPEPTIDASE A
(Arabidopsis
thaliana) 		3 / 3 VAL A 668
GLY A 670
LYS A 360
 None
 0.76A 4k50I-4ka8A:
1.8		 4k50I-4ka8A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 4ka8 OLIGOPEPTIDASE A
(Arabidopsis
thaliana) 		5 / 12 HIS A 571
GLU A 572
HIS A 575
GLU A 601
TYR A 716
 ZN  A 801 (-3.3A)
ZN  A 801 ( 4.6A)
ZN  A 801 (-3.3A)
ZN  A 801 (-2.1A)
None
 0.60A 4r7lA-4ka8A:
7.0		 4r7lA-4ka8A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_2
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))		 4ka8 OLIGOPEPTIDASE A
(Arabidopsis
thaliana) 		4 / 7 GLU A 448
SER A 559
GLU A 565
ASP A 508
 None
 1.15A 4uacA-4ka8A:
undetectable		 4uacA-4ka8A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XOY_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 4ka8 OLIGOPEPTIDASE A
(Arabidopsis
thaliana) 		4 / 6 ALA A 719
GLN A 605
LEU A 722
LEU A 778
 None
GOL  A 803 (-4.9A)
GOL  A 805 ( 4.8A)
None
 0.98A 4xoyA-4ka8A:
undetectable		 4xoyA-4ka8A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP3_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 4ka8 OLIGOPEPTIDASE A
(Arabidopsis
thaliana) 		4 / 6 ALA A 719
GLN A 605
LEU A 722
LEU A 778
 None
GOL  A 803 (-4.9A)
GOL  A 805 ( 4.8A)
None
 1.00A 4xp3A-4ka8A:
undetectable		 4xp3A-4ka8A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4ka8 OLIGOPEPTIDASE A
(Arabidopsis
thaliana) 		4 / 6 LEU A 361
TYR A 374
LYS A 365
GLU A 250
 None
 1.32A 4z4gA-4ka8A:
2.9		 4z4gA-4ka8A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSY_B_ACRB601_2
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)		 4ka8 OLIGOPEPTIDASE A
(Arabidopsis
thaliana) 		4 / 5 TYR A 504
PHE A 573
HIS A 579
LEU A 581
 GOL  A 804 (-4.7A)
None
None
None
 1.43A 5csyB-4ka8A:
undetectable		 5csyB-4ka8A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA302_1
(CHITOSANASE)		 4ka8 OLIGOPEPTIDASE A
(Arabidopsis
thaliana) 		4 / 7 ASP A 598
TYR A 714
GLY A 712
TYR A 374
 None
 0.99A 5hwaA-4ka8A:
undetectable		 5hwaA-4ka8A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 4ka8 OLIGOPEPTIDASE A
(Arabidopsis
thaliana) 		3 / 3 ASP A 496
ASN A 750
GLN A 746
 None
 0.76A 5k7uA-4ka8A:
undetectable		 5k7uA-4ka8A:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM8_B_L8PB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 4ka8 OLIGOPEPTIDASE A
(Arabidopsis
thaliana) 		4 / 8 GLN A 653
ASN A 782
ALA A 646
SER A 400
 None
GOL  A 803 ( 4.8A)
None
None
 1.15A 5km8A-4ka8A:
undetectable
5km8B-4ka8A:
undetectable		 5km8A-4ka8A:
12.23
5km8B-4ka8A:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJD_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 4ka8 OLIGOPEPTIDASE A
(Arabidopsis
thaliana) 		5 / 9 LEU A 577
LEU A 466
ILE A 475
GLN A 550
MET A 546
 None
 1.46A 5ljdA-4ka8A:
undetectable		 5ljdA-4ka8A:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OAJ_E_TKTE601_1
()		 4ka8 OLIGOPEPTIDASE A
(Arabidopsis
thaliana) 		4 / 8 TYR A 612
PHE A 644
TYR A 443
ARG A 439
 None
 1.39A 5oajD-4ka8A:
undetectable
5oajE-4ka8A:
undetectable		 5oajD-4ka8A:
16.57
5oajE-4ka8A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BC9_A_ETSA302_2
(CARBONIC ANHYDRASE 2)		 4ka8 OLIGOPEPTIDASE A
(Arabidopsis
thaliana) 		4 / 5 HIS A 545
GLU A 572
HIS A 575
VAL A 600
 None
ZN  A 801 ( 4.6A)
ZN  A 801 (-3.3A)
None
 1.14A 6bc9A-4ka8A:
undetectable		 6bc9A-4ka8A:
7.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4ka8 OLIGOPEPTIDASE A
(Arabidopsis
thaliana) 		4 / 6 ARG A 645
GLN A 325
PHE A 433
LEU A 411
 None
 1.25A 6nmpC-4ka8A:
4.2
6nmpJ-4ka8A:
undetectable		 6nmpC-4ka8A:
16.02
6nmpJ-4ka8A:
7.23