SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kam'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C3S_A_SHHA952_1
(HDLP (HISTONE
DEACETYLASE-LIKE
PROTEIN))		 4kam O-ACETYLHOMOSERINE
SULFHYDRYLASE METC
(Mycobacterium
marinum) 		5 / 11 HIS A 376
PHE A 367
HIS A 374
ASP A 428
LEU A 429
 None
 1.19A 1c3sA-4kamA:
3.2		 1c3sA-4kamA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKF_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 4kam O-ACETYLHOMOSERINE
SULFHYDRYLASE METC
(Mycobacterium
marinum) 		5 / 11 TYR A 329
ILE A 198
TYR A 221
HIS A 307
ILE A 304
 None
 1.26A 1fkfA-4kamA:
undetectable		 1fkfA-4kamA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKJ_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 4kam O-ACETYLHOMOSERINE
SULFHYDRYLASE METC
(Mycobacterium
marinum) 		5 / 11 TYR A 329
ILE A 198
TYR A 221
HIS A 307
ILE A 304
 None
 1.27A 1fkjA-4kamA:
undetectable		 1fkjA-4kamA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P2Y_A_NCTA440_1
(CYTOCHROME P450-CAM)		 4kam O-ACETYLHOMOSERINE
SULFHYDRYLASE METC
(Mycobacterium
marinum) 		4 / 7 GLY A  87
ASP A 212
ILE A 213
VAL A 214
 None
 0.69A 1p2yA-4kamA:
undetectable		 1p2yA-4kamA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1301_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 4kam O-ACETYLHOMOSERINE
SULFHYDRYLASE METC
(Mycobacterium
marinum) 		4 / 6 LEU A 106
PHE A 103
ALA A 104
LEU A 133
 None
 0.82A 1ukbA-4kamA:
undetectable		 1ukbA-4kamA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 4kam O-ACETYLHOMOSERINE
SULFHYDRYLASE METC
(Mycobacterium
marinum) 		5 / 11 LEU A 318
HIS A 376
PHE A 367
HIS A 374
ASP A 428
 None
 1.11A 1zz1A-4kamA:
undetectable		 1zz1A-4kamA:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 4kam O-ACETYLHOMOSERINE
SULFHYDRYLASE METC
(Mycobacterium
marinum) 		5 / 12 LEU A 318
HIS A 376
PHE A 367
HIS A 374
ASP A 428
 None
 1.10A 1zz1B-4kamA:
undetectable
1zz1C-4kamA:
undetectable		 1zz1B-4kamA:
25.05
1zz1C-4kamA:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 4kam O-ACETYLHOMOSERINE
SULFHYDRYLASE METC
(Mycobacterium
marinum) 		5 / 10 THR A 102
ALA A 100
ALA A 104
GLY A 124
ASP A 195
 None
 1.04A 2f16K-4kamA:
undetectable
2f16L-4kamA:
undetectable		 2f16K-4kamA:
19.28
2f16L-4kamA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 4kam O-ACETYLHOMOSERINE
SULFHYDRYLASE METC
(Mycobacterium
marinum) 		5 / 10 THR A 102
ALA A 100
ALA A 104
GLY A 124
ASP A 195
 None
 1.01A 2f16Y-4kamA:
undetectable
2f16Z-4kamA:
undetectable		 2f16Y-4kamA:
19.28
2f16Z-4kamA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FKE_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 4kam O-ACETYLHOMOSERINE
SULFHYDRYLASE METC
(Mycobacterium
marinum) 		5 / 11 TYR A 329
ILE A 198
TYR A 221
HIS A 307
ILE A 304
 None
 1.28A 2fkeA-4kamA:
undetectable		 2fkeA-4kamA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_4
(PROTEASE RETROPEPSIN)		 4kam O-ACETYLHOMOSERINE
SULFHYDRYLASE METC
(Mycobacterium
marinum) 		3 / 3 ASP A 382
THR A 200
PRO A 201
 None
 0.59A 2q64B-4kamA:
undetectable		 2q64B-4kamA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRH_A_NIOA200_1
(PROTEIN HP0721)		 4kam O-ACETYLHOMOSERINE
SULFHYDRYLASE METC
(Mycobacterium
marinum) 		4 / 7 GLY A 224
ILE A 304
ARG A 303
LEU A 222
 None
 0.98A 2xrhA-4kamA:
undetectable		 2xrhA-4kamA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_A_SAMA270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 4kam O-ACETYLHOMOSERINE
SULFHYDRYLASE METC
(Mycobacterium
marinum) 		5 / 12 LEU A 429
ALA A 427
GLY A 432
ILE A 425
LEU A 373
 None
 1.09A 3gyqA-4kamA:
undetectable
3gyqB-4kamA:
2.3		 3gyqA-4kamA:
25.84
3gyqB-4kamA:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 4kam O-ACETYLHOMOSERINE
SULFHYDRYLASE METC
(Mycobacterium
marinum) 		4 / 6 TYR A 122
GLY A 124
THR A 125
LEU A 121
 SO4  A 502 (-4.5A)
None
None
None
 1.01A 3ps9A-4kamA:
undetectable		 3ps9A-4kamA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_3
(PROTEASE)		 4kam O-ACETYLHOMOSERINE
SULFHYDRYLASE METC
(Mycobacterium
marinum) 		3 / 3 ASP A 382
THR A 200
PRO A 201
 None
 0.61A 3tkgD-4kamA:
undetectable		 3tkgD-4kamA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4kam O-ACETYLHOMOSERINE
SULFHYDRYLASE METC
(Mycobacterium
marinum) 		6 / 10 THR A 102
ALA A 100
ALA A 104
GLY A 124
THR A 125
ASP A 195
 None
 1.14A 4qvyK-4kamA:
undetectable
4qvyL-4kamA:
undetectable		 4qvyK-4kamA:
19.28
4qvyL-4kamA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4kam O-ACETYLHOMOSERINE
SULFHYDRYLASE METC
(Mycobacterium
marinum) 		6 / 10 THR A 102
ALA A 100
ALA A 104
GLY A 124
THR A 125
ASP A 195
 None
 1.14A 4qvyY-4kamA:
undetectable
4qvyZ-4kamA:
undetectable		 4qvyY-4kamA:
19.28
4qvyZ-4kamA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 4kam O-ACETYLHOMOSERINE
SULFHYDRYLASE METC
(Mycobacterium
marinum) 		5 / 12 ILE A 168
ALA A 330
GLN A 312
SER A 345
LEU A 203
 None
 1.48A 4qztC-4kamA:
undetectable		 4qztC-4kamA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y4D_A_CFFA411_1
(ENDOTHIAPEPSIN)		 4kam O-ACETYLHOMOSERINE
SULFHYDRYLASE METC
(Mycobacterium
marinum) 		4 / 6 LEU A 277
LEU A  94
PHE A 103
ILE A 213
 None
 1.12A 4y4dA-4kamA:
undetectable		 4y4dA-4kamA:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1006_1
(SERUM ALBUMIN)		 4kam O-ACETYLHOMOSERINE
SULFHYDRYLASE METC
(Mycobacterium
marinum) 		4 / 7 ILE A 168
LEU A 175
TYR A 329
GLY A 348
 None
 1.04A 4z69A-4kamA:
undetectable		 4z69A-4kamA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_B_TESB502_1
(-)		 4kam O-ACETYLHOMOSERINE
SULFHYDRYLASE METC
(Mycobacterium
marinum) 		5 / 12 LEU A 429
VAL A 368
LEU A 371
LEU A 318
LEU A 412
 None
 1.14A 5og9B-4kamA:
undetectable		 5og9B-4kamA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		 4kam O-ACETYLHOMOSERINE
SULFHYDRYLASE METC
(Mycobacterium
marinum) 		5 / 9 ALA A 218
SER A 217
ALA A 228
GLY A 223
GLY A 226
 None
SO4  A 501 (-2.7A)
None
None
None
 1.14A 6bklE-4kamA:
undetectable
6bklF-4kamA:
undetectable
6bklG-4kamA:
undetectable
6bklH-4kamA:
undetectable		 6bklE-4kamA:
4.05
6bklF-4kamA:
4.05
6bklG-4kamA:
4.05
6bklH-4kamA:
4.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IFT_A_SAMA301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)		 4kam O-ACETYLHOMOSERINE
SULFHYDRYLASE METC
(Mycobacterium
marinum) 		5 / 12 ILE A 380
GLY A 381
GLY A 224
ALA A 227
VAL A 352
 None
 0.81A 6iftA-4kamA:
2.6		 6iftA-4kamA:
21.90