SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kav'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_1
(HIV-1 PROTEASE)		 4kav YHBX/YHJW/YIJP/YJDB
FAMILY PROTEIN
(Neisseria
meningitidis) 		5 / 9 LEU A 217
ASP A 218
VAL A 311
GLY A 520
ILE A 310
 None
 1.01A 1hpvA-4kavA:
undetectable		 1hpvA-4kavA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_A_CILA451_1
(RENAL DIPEPTIDASE)		 4kav YHBX/YHJW/YIJP/YJDB
FAMILY PROTEIN
(Neisseria
meningitidis) 		5 / 12 ASP A 324
HIS A 453
HIS A 465
HIS A 383
TYR A 387
 TPO  A 280 ( 3.9A)
ZN  A 601 ( 3.2A)
TPO  A 280 (-3.9A)
NA  A 606 ( 3.7A)
None
 1.50A 1ituA-4kavA:
undetectable		 1ituA-4kavA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_B_CILB452_1
(RENAL DIPEPTIDASE)		 4kav YHBX/YHJW/YIJP/YJDB
FAMILY PROTEIN
(Neisseria
meningitidis) 		5 / 12 ASP A 324
HIS A 453
HIS A 465
HIS A 383
TYR A 387
 TPO  A 280 ( 3.9A)
ZN  A 601 ( 3.2A)
TPO  A 280 (-3.9A)
NA  A 606 ( 3.7A)
None
 1.50A 1ituB-4kavA:
undetectable		 1ituB-4kavA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_J_BEZJ5041_0
(CES1 PROTEIN)		 4kav YHBX/YHJW/YIJP/YJDB
FAMILY PROTEIN
(Neisseria
meningitidis) 		4 / 4 GLY A 277
SER A 283
ILE A 479
HIS A 511
 None
TPO  A 280 ( 4.5A)
None
None
 1.08A 1yajJ-4kavA:
undetectable		 1yajJ-4kavA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B304_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 4kav YHBX/YHJW/YIJP/YJDB
FAMILY PROTEIN
(Neisseria
meningitidis) 		4 / 5 ASN A 250
THR A 241
SER A 451
SER A 275
 None
 1.49A 3hlwB-4kavA:
undetectable		 3hlwB-4kavA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6P_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4kav YHBX/YHJW/YIJP/YJDB
FAMILY PROTEIN
(Neisseria
meningitidis) 		5 / 12 VAL A 334
LEU A 519
PHE A 288
THR A 517
LEU A 236
 None
 1.29A 3j6pB-4kavA:
undetectable		 3j6pB-4kavA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_A_NCAA192_0
(NICOTINAMIDASE)		 4kav YHBX/YHJW/YIJP/YJDB
FAMILY PROTEIN
(Neisseria
meningitidis) 		5 / 11 LEU A 521
ASP A 523
PHE A 489
LEU A 537
ILE A 495
 None
 1.46A 3o94A-4kavA:
undetectable		 3o94A-4kavA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_C_NCAC192_0
(NICOTINAMIDASE)		 4kav YHBX/YHJW/YIJP/YJDB
FAMILY PROTEIN
(Neisseria
meningitidis) 		5 / 11 LEU A 521
ASP A 523
PHE A 489
LEU A 537
ILE A 495
 None
 1.49A 3o94C-4kavA:
undetectable		 3o94C-4kavA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_D_NCAD192_0
(NICOTINAMIDASE)		 4kav YHBX/YHJW/YIJP/YJDB
FAMILY PROTEIN
(Neisseria
meningitidis) 		5 / 11 LEU A 521
ASP A 523
PHE A 489
LEU A 537
ILE A 495
 None
 1.49A 3o94D-4kavA:
undetectable		 3o94D-4kavA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_2
(POL POLYPROTEIN)		 4kav YHBX/YHJW/YIJP/YJDB
FAMILY PROTEIN
(Neisseria
meningitidis) 		5 / 9 GLY A 520
ASP A 372
GLY A 493
ILE A 495
VAL A 234
 None
 1.00A 3u7sB-4kavA:
undetectable		 3u7sB-4kavA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYS_A_ACTA402_0
(MCCC FAMILY PROTEIN)		 4kav YHBX/YHJW/YIJP/YJDB
FAMILY PROTEIN
(Neisseria
meningitidis) 		4 / 6 SER A 325
ASP A 324
ARG A 390
GLU A 352
 None
TPO  A 280 ( 3.9A)
NA  A 606 (-4.1A)
NA  A 606 (-3.2A)
 1.22A 4eysA-4kavA:
undetectable		 4eysA-4kavA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_C_3CJC607_1
(LACTOPEROXIDASE)		 4kav YHBX/YHJW/YIJP/YJDB
FAMILY PROTEIN
(Neisseria
meningitidis) 		4 / 6 ASP A 512
HIS A 513
GLU A 508
ARG A 293
 None
 1.46A 4qyqC-4kavA:
undetectable		 4qyqC-4kavA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4kav YHBX/YHJW/YIJP/YJDB
FAMILY PROTEIN
(Neisseria
meningitidis) 		4 / 6 THR A 411
ALA A 413
THR A 414
VAL A 416
 None
 0.94A 5ecoA-4kavA:
undetectable		 5ecoA-4kavA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 4kav YHBX/YHJW/YIJP/YJDB
FAMILY PROTEIN
(Neisseria
meningitidis) 		5 / 12 PRO A 473
GLY A 458
LEU A 415
ASN A 460
GLU A 455
 None
 1.33A 5emlA-4kavA:
undetectable		 5emlA-4kavA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GLM_A_ACTA613_0
(GLYCOSIDE HYDROLASE
FAMILY 43)		 4kav YHBX/YHJW/YIJP/YJDB
FAMILY PROTEIN
(Neisseria
meningitidis) 		3 / 3 ASP A 420
SER A 253
TYR A 252
 None
 0.90A 5glmA-4kavA:
undetectable		 5glmA-4kavA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPW_C_3CJC609_1
(LACTOPEROXIDASE)		 4kav YHBX/YHJW/YIJP/YJDB
FAMILY PROTEIN
(Neisseria
meningitidis) 		4 / 6 ASP A 512
HIS A 513
GLU A 508
ARG A 293
 None
 1.46A 5hpwC-4kavA:
undetectable		 5hpwC-4kavA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 4kav YHBX/YHJW/YIJP/YJDB
FAMILY PROTEIN
(Neisseria
meningitidis) 		5 / 12 VAL A 237
THR A 379
PHE A 362
LEU A 366
VAL A 365
 None
 1.33A 6a93B-4kavA:
undetectable		 6a93B-4kavA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CHG_C_SAMC1101_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-4 SPECIFIC)		 4kav YHBX/YHJW/YIJP/YJDB
FAMILY PROTEIN
(Neisseria
meningitidis) 		5 / 12 ASN A 356
SER A 382
ASN A 323
HIS A 378
LEU A 377
 None
None
None
TPO  A 280 ( 4.8A)
None
 1.33A 6chgC-4kavA:
undetectable		 6chgC-4kavA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		 4kav YHBX/YHJW/YIJP/YJDB
FAMILY PROTEIN
(Neisseria
meningitidis) 		4 / 8 GLY A 454
GLN A 476
THR A 477
SER A 451
 None
 1.15A 6eqpA-4kavA:
undetectable		 6eqpA-4kavA:
11.90