SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kbf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_1
(TRANSTHYRETIN)		 4kbf HEAT RESISTANT RNA
DEPENDENT ATPASE
(Thermus
thermophilus) 		4 / 7 LEU A  78
ALA A 148
SER A 182
THR A 178
 None
 0.85A 1dvxA-4kbfA:
undetectable		 1dvxA-4kbfA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J7K_A_ACTA701_0
(HOLLIDAY JUNCTION
DNA HELICASE RUVB)		 4kbf HEAT RESISTANT RNA
DEPENDENT ATPASE
(Thermus
thermophilus) 		4 / 4 GLY A  20
LEU A  21
GLY A  18
ARG A  19
 None
AMP  A 401 (-4.6A)
None
None
 1.38A 1j7kA-4kbfA:
6.8		 1j7kA-4kbfA:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)		 4kbf HEAT RESISTANT RNA
DEPENDENT ATPASE
(Thermus
thermophilus) 		5 / 12 LEU A 272
GLY A 270
VAL A 297
GLN A 266
LEU A 292
 None
 1.36A 1nhzA-4kbfA:
undetectable		 1nhzA-4kbfA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_2
(ANCESTRAL STEROID
RECEPTOR 2)		 4kbf HEAT RESISTANT RNA
DEPENDENT ATPASE
(Thermus
thermophilus) 		4 / 8 ALA A 153
MET A 156
THR A 172
VAL A 145
 None
 0.90A 4ltwA-4kbfA:
undetectable		 4ltwA-4kbfA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		 4kbf HEAT RESISTANT RNA
DEPENDENT ATPASE
(Thermus
thermophilus) 		5 / 12 LEU A 272
GLY A 270
VAL A 297
GLN A 266
LEU A 292
 None
 1.43A 5uc3B-4kbfA:
undetectable		 5uc3B-4kbfA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_D_HFGD1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 4kbf HEAT RESISTANT RNA
DEPENDENT ATPASE
(Thermus
thermophilus) 		5 / 12 LEU A 229
VAL A 311
THR A 245
GLU A 250
ARG A 325
 None
 1.19A 5xipD-4kbfA:
undetectable		 5xipD-4kbfA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 4kbf HEAT RESISTANT RNA
DEPENDENT ATPASE
(Thermus
thermophilus) 		5 / 12 VAL A 125
THR A  79
LEU A  99
PHE A  55
VAL A 147
 None
 1.10A 6a93B-4kbfA:
undetectable		 6a93B-4kbfA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_B_ACTB804_0
(UNCHARACTERIZED
PROTEIN)		 4kbf HEAT RESISTANT RNA
DEPENDENT ATPASE
(Thermus
thermophilus) 		4 / 4 HIS A 269
VAL A 280
LEU A 272
ALA A 267
 None
 0.90A 6d8pB-4kbfA:
2.1		 6d8pB-4kbfA:
21.18