SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kbm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EUP_A_ASDA452_1
(CYTOCHROME P450ERYF)		 4kbm DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Mycobacterium
tuberculosis) 		4 / 8 PHE A 151
ILE A 383
LEU A  58
LEU A  84
 None
 0.75A 1eupA-4kbmA:
undetectable		 1eupA-4kbmA:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI518_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4kbm DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Mycobacterium
tuberculosis) 		4 / 7 GLY A  95
PRO A  89
ASN A 135
ASN A 136
 None
 0.89A 1oniG-4kbmA:
undetectable
1oniI-4kbmA:
undetectable		 1oniG-4kbmA:
16.22
1oniI-4kbmA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4kbm DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
RNA
POLYMERASE-BINDING
TRANSCRIPTION FACTOR
CARD
(Mycobacterium
tuberculosis) 		5 / 12 THR A 138
LEU B  37
VAL B  19
PHE B   3
VAL B  58
 None
 1.23A 1q23B-4kbmA:
undetectable		 1q23B-4kbmA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4kbm DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
RNA
POLYMERASE-BINDING
TRANSCRIPTION FACTOR
CARD
(Mycobacterium
tuberculosis) 		5 / 11 THR A 138
LEU B  37
VAL B  19
PHE B   3
VAL B  58
 None
 1.28A 1q23I-4kbmA:
undetectable		 1q23I-4kbmA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_1
(RETINOIC ACID
RECEPTOR, BETA)		 4kbm RNA
POLYMERASE-BINDING
TRANSCRIPTION FACTOR
CARD
(Mycobacterium
tuberculosis) 		5 / 12 ALA B 142
LEU B 135
ILE B 153
PHE B  71
LEU B  74
 None
 0.71A 1xdkF-4kbmB:
undetectable		 1xdkF-4kbmB:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		 4kbm RNA
POLYMERASE-BINDING
TRANSCRIPTION FACTOR
CARD
(Mycobacterium
tuberculosis) 		4 / 5 VAL B 101
ASN B 102
VAL B  62
ILE B   2
 None
 0.95A 1z2bC-4kbmB:
undetectable		 1z2bC-4kbmB:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4kbm DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Mycobacterium
tuberculosis) 		4 / 6 GLY A  78
GLY A 376
PHE A 151
PHE A 106
 None
 0.88A 2qx6A-4kbmA:
undetectable
2qx6B-4kbmA:
undetectable		 2qx6A-4kbmA:
20.29
2qx6B-4kbmA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLJ_A_SPMA1303_1
(POTASSIUM CHANNEL)		 4kbm DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 392
ARG A 276
PRO A 277
 None
 1.05A 2wljA-4kbmA:
undetectable		 2wljA-4kbmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A9E_B_REAB1_1
(RETINOIC ACID
RECEPTOR ALPHA)		 4kbm DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Mycobacterium
tuberculosis) 		5 / 11 ILE A 379
PHE A  55
SER A  54
PHE A 151
VAL A 129
 None
 1.23A 3a9eB-4kbmA:
undetectable		 3a9eB-4kbmA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_1
(PROTEIN S100-A4)		 4kbm DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Mycobacterium
tuberculosis) 		3 / 3 GLU A 266
LEU A 269
ASP A 270
 None
 0.36A 3ko0A-4kbmA:
undetectable		 3ko0A-4kbmA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_2
(PROTEIN S100-A4)		 4kbm DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Mycobacterium
tuberculosis) 		3 / 3 GLU A 266
LEU A 269
ASP A 270
 None
 0.28A 3ko0T-4kbmA:
undetectable		 3ko0T-4kbmA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4kbm DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 421
ALA A 420
LEU A  80
LEU A  58
PHE A 425
 None
 0.85A 3uvvA-4kbmA:
undetectable		 3uvvA-4kbmA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 4kbm DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Mycobacterium
tuberculosis) 		4 / 7 THR A 255
VAL A 210
ASP A 214
VAL A 216
 None
 0.82A 4cp4A-4kbmA:
undetectable		 4cp4A-4kbmA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4kbm DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 202
TRP A  57
GLY A  79
 None
 0.99A 4e7cA-4kbmA:
undetectable		 4e7cA-4kbmA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4kbm DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Mycobacterium
tuberculosis) 		5 / 10 GLY A  79
GLY A  78
ASN A 381
PHE A 151
PHE A 106
 None
 1.29A 4fgkA-4kbmA:
undetectable
4fgkB-4kbmA:
undetectable		 4fgkA-4kbmA:
20.83
4fgkB-4kbmA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4kbm DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Mycobacterium
tuberculosis) 		3 / 3 ASP A 259
ARG A 224
THR A 229
 None
 0.80A 4i13A-4kbmA:
undetectable		 4i13A-4kbmA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4kbm DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Mycobacterium
tuberculosis) 		3 / 3 ASP A 259
ARG A 224
THR A 229
 None
 0.81A 4p3rA-4kbmA:
undetectable		 4p3rA-4kbmA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4kbm DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Mycobacterium
tuberculosis) 		4 / 5 THR A 215
GLY A 217
HIS A 194
ASP A 211
 None
 1.24A 5c0oH-4kbmA:
undetectable		 5c0oH-4kbmA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4kbm DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Mycobacterium
tuberculosis) 		3 / 3 GLN A 380
TRP A  57
VAL A  77
 None
 1.07A 6auuA-4kbmA:
undetectable		 6auuA-4kbmA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA607_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 4kbm DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Mycobacterium
tuberculosis) 		4 / 4 GLY A 315
ARG A 307
ASN A 311
LEU A 314
 None
 1.41A 6b58A-4kbmA:
undetectable		 6b58A-4kbmA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPL_B_PA1B605_1
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)		 4kbm DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 373
ARG A 222
ARG A 384
 None
 1.06A 6bplA-4kbmA:
undetectable
6bplB-4kbmA:
undetectable		 6bplA-4kbmA:
12.32
6bplB-4kbmA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4kbm DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Mycobacterium
tuberculosis) 		4 / 6 VAL A 375
PHE A 151
PHE A 425
PHE A 424
 None
 0.92A 6h7lA-4kbmA:
undetectable		 6h7lA-4kbmA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_B_Y00B405_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4kbm DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
(Mycobacterium
tuberculosis) 		4 / 6 VAL A 375
PHE A 151
PHE A 425
PHE A 424
 None
 0.92A 6h7lB-4kbmA:
undetectable		 6h7lB-4kbmA:
12.35