SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kbo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Y_B_MK1B524_1
(PROTEIN (PROTEASE))		 4kbo STRESS-70 PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		6 / 11 ALA A 204
ILE A 191
GLY A 209
ILE A 211
THR A 120
ILE A 124
 None
 1.17A 1c6yA-4kboA:
undetectable		 1c6yA-4kboA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNJ_A_225A501_1
(CYTOCHROME P450 2C8)		 4kbo STRESS-70 PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ILE A 124
ALA A 204
VAL A 219
VAL A 193
ILE A 191
 None
 1.05A 2nnjA-4kboA:
undetectable		 2nnjA-4kboA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_A_ECNA1409_1
(CYTOCHROME P450 130)		 4kbo STRESS-70 PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ASP A 136
THR A 249
GLY A 248
GLY A 247
THR A  63
 None
NA  A 501 ( 4.6A)
None
None
None
 1.17A 2uvnA-4kboA:
undetectable		 2uvnA-4kboA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_A_BEZA1222_0
(PEROXIREDOXIN 6)		 4kbo STRESS-70 PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 PRO A 113
VAL A 110
ARG A 309
PRO A 141
 None
 0.99A 2v2gA-4kboA:
undetectable
2v2gB-4kboA:
undetectable		 2v2gA-4kboA:
21.94
2v2gB-4kboA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_B_BEZB1220_0
(PEROXIREDOXIN 6)		 4kbo STRESS-70 PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 PRO A 141
PRO A 113
VAL A 110
ARG A 309
 None
 0.94A 2v2gA-4kboA:
undetectable
2v2gB-4kboA:
undetectable		 2v2gA-4kboA:
21.94
2v2gB-4kboA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_C_BEZC1222_0
(PEROXIREDOXIN 6)		 4kbo STRESS-70 PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 PRO A 113
VAL A 110
ARG A 309
PRO A 141
 None
 1.01A 2v2gC-4kboA:
undetectable
2v2gD-4kboA:
undetectable		 2v2gC-4kboA:
21.94
2v2gD-4kboA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_D_BEZD1221_0
(PEROXIREDOXIN 6)		 4kbo STRESS-70 PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 PRO A 141
PRO A 113
VAL A 110
ARG A 309
 None
 0.94A 2v2gC-4kboA:
undetectable
2v2gD-4kboA:
undetectable		 2v2gC-4kboA:
21.94
2v2gD-4kboA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_B_BEZB1220_0
(PEROXIREDOXIN 6)		 4kbo STRESS-70 PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 PRO A 141
PRO A 113
VAL A 110
ARG A 309
 None
 0.94A 2v32A-4kboA:
undetectable
2v32B-4kboA:
undetectable		 2v32A-4kboA:
21.94
2v32B-4kboA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_C_BEZC1222_0
(PEROXIREDOXIN 6)		 4kbo STRESS-70 PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 PRO A 113
VAL A 110
ARG A 309
PRO A 141
 None
 0.99A 2v32C-4kboA:
undetectable
2v32D-4kboA:
undetectable		 2v32C-4kboA:
21.94
2v32D-4kboA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_D_BEZD1222_0
(PEROXIREDOXIN 6.)		 4kbo STRESS-70 PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 PRO A 141
PRO A 113
VAL A 110
ARG A 309
 None
 0.99A 2v41C-4kboA:
undetectable
2v41D-4kboA:
undetectable		 2v41C-4kboA:
21.94
2v41D-4kboA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_E_BEZE1222_0
(PEROXIREDOXIN 6.)		 4kbo STRESS-70 PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 PRO A 113
VAL A 110
ARG A 309
PRO A 141
 None
 0.97A 2v41E-4kboA:
undetectable
2v41F-4kboA:
undetectable		 2v41E-4kboA:
21.94
2v41F-4kboA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_F_BEZF1222_0
(PEROXIREDOXIN 6.)		 4kbo STRESS-70 PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 PRO A 141
PRO A 113
VAL A 110
ARG A 309
 None
 0.98A 2v41E-4kboA:
undetectable
2v41F-4kboA:
undetectable		 2v41E-4kboA:
21.94
2v41F-4kboA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_G_BEZG1222_0
(PEROXIREDOXIN 6.)		 4kbo STRESS-70 PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 PRO A 113
VAL A 110
ARG A 309
PRO A 141
 None
 0.96A 2v41G-4kboA:
undetectable
2v41H-4kboA:
undetectable		 2v41G-4kboA:
21.94
2v41H-4kboA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_H_BEZH1222_0
(PEROXIREDOXIN 6.)		 4kbo STRESS-70 PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 PRO A 141
PRO A 113
VAL A 110
ARG A 309
 None
 0.95A 2v41G-4kboA:
undetectable
2v41H-4kboA:
undetectable		 2v41G-4kboA:
21.94
2v41H-4kboA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN0_A_TDZA501_1
(CYTOCHROME P450 2C8)		 4kbo STRESS-70 PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 191
LEU A 171
VAL A 216
VAL A  56
GLU A 179
 None
 1.13A 2vn0A-4kboA:
undetectable		 2vn0A-4kboA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN0_A_TDZA501_1
(CYTOCHROME P450 2C8)		 4kbo STRESS-70 PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 191
THR A 192
LEU A 171
VAL A 216
GLU A 179
 None
 1.09A 2vn0A-4kboA:
undetectable		 2vn0A-4kboA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 4kbo STRESS-70 PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ARG A 126
ASP A 151
ASP A 130
 None
 0.75A 3jb3A-4kboA:
undetectable		 3jb3A-4kboA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3005_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4kbo STRESS-70 PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 ASN A 221
THR A 224
LEU A 228
ALA A 421
 None
 0.92A 3kp6A-4kboA:
undetectable		 3kp6A-4kboA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD507_1
(HEMOLYTIC LECTIN
CEL-III)		 4kbo STRESS-70 PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 ASP A 277
GLU A 276
GLY A 248
ASP A 270
 None
 1.34A 3w9tD-4kboA:
undetectable		 3w9tD-4kboA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB307_1
(CHITOSANASE)		 4kbo STRESS-70 PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 GLU A 222
THR A  62
GLY A  61
THR A  63
 NA  A 501 ( 4.2A)
NA  A 501 (-4.1A)
NA  A 501 ( 3.8A)
None
 1.00A 4qwpB-4kboA:
undetectable		 4qwpB-4kboA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZGF_A_BEZA210_0
(UNCHARACTERIZED
PROTEIN)		 4kbo STRESS-70 PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 4 VAL A  91
ALA A  92
ASN A 115
GLN A 108
 None
 1.43A 4zgfA-4kboA:
undetectable		 4zgfA-4kboA:
17.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_A_ADNA1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 4kbo STRESS-70 PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		6 / 10 GLY A 246
GLY A 275
LYS A 316
SER A 320
GLY A 388
ARG A 391
 None
 1.21A 5aqfA-4kboA:
50.8		 5aqfA-4kboA:
54.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_A_ADNA1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 4kbo STRESS-70 PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 GLY A 247
GLY A 275
LYS A 316
SER A 320
GLY A 388
 None
 0.45A 5aqfA-4kboA:
50.8		 5aqfA-4kboA:
54.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_C_ADNC1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 4kbo STRESS-70 PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		6 / 10 GLY A 246
GLY A 275
LYS A 316
SER A 320
GLY A 388
ARG A 391
 None
 1.20A 5aqfC-4kboA:
50.7		 5aqfC-4kboA:
54.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_C_ADNC1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 4kbo STRESS-70 PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 GLY A 247
GLY A 275
LYS A 316
SER A 320
GLY A 388
 None
 0.42A 5aqfC-4kboA:
50.7		 5aqfC-4kboA:
54.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQY_A_ADNA1389_1
(HEAT SHOCK 70 KDA
PROTEIN 1A)		 4kbo STRESS-70 PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		6 / 10 GLY A 246
GLY A 275
LYS A 316
SER A 320
GLY A 388
ARG A 391
 None
 1.20A 5aqyA-4kboA:
53.6		 5aqyA-4kboA:
52.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQY_A_ADNA1389_1
(HEAT SHOCK 70 KDA
PROTEIN 1A)		 4kbo STRESS-70 PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 GLY A 247
GLY A 275
LYS A 316
SER A 320
GLY A 388
 None
 0.46A 5aqyA-4kboA:
53.6		 5aqyA-4kboA:
52.62