SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4kc3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_0
(ALCOHOL
DEHYDROGENASE)		 4kc3 INTERLEUKIN-33
(Homo
sapiens) 		5 / 11 LEU A 267
LEU A 247
LEU A 186
VAL A 228
ILE A 240
 None
 1.14A 1ee2A-4kc3A:
undetectable		 1ee2A-4kc3A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_1
(ALCOHOL
DEHYDROGENASE)		 4kc3 INTERLEUKIN-33
(Homo
sapiens) 		5 / 11 LEU A 267
LEU A 247
LEU A 186
VAL A 228
ILE A 240
 None
 1.21A 1ee2B-4kc3A:
undetectable		 1ee2B-4kc3A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_F_ACTF3008_0
(BETA-CARBONIC
ANHYDRASE)		 4kc3 INTERLEUKIN-1
RECEPTOR-LIKE 1
(Homo
sapiens) 		5 / 8 PHE B  74
TYR B  85
ASP B  81
VAL B 102
GLY B  83
 None
 1.21A 1ekjE-4kc3B:
undetectable
1ekjF-4kc3B:
undetectable		 1ekjE-4kc3B:
22.08
1ekjF-4kc3B:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN)		 4kc3 INTERLEUKIN-33
INTERLEUKIN-1
RECEPTOR-LIKE 1
(Homo
sapiens;
Homo
sapiens) 		5 / 12 LEU A 220
LEU B 308
LEU A 161
ILE A 240
HIS A 224
 None
 1.15A 1tw4A-4kc3A:
undetectable		 1tw4A-4kc3A:
27.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7L_A_TESA155_1
(ANDROGEN RECEPTOR)		 4kc3 INTERLEUKIN-1
RECEPTOR-LIKE 1
INTERLEUKIN-33
(Homo
sapiens) 		5 / 12 LEU B 306
ASN B 307
LEU B 311
GLY B 310
VAL A 184
 None
 1.26A 2q7lA-4kc3B:
undetectable		 2q7lA-4kc3B:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_A_FOLA401_0
(DIHYDROFOLATE
REDUCTASE)		 4kc3 INTERLEUKIN-1
RECEPTOR-LIKE 1
(Homo
sapiens) 		5 / 12 ALA B  80
PHE B  74
ILE B  57
PRO B  58
LEU B  72
 None
 0.98A 2w3bA-4kc3B:
undetectable		 2w3bA-4kc3B:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		 4kc3 INTERLEUKIN-1
RECEPTOR-LIKE 1
INTERLEUKIN-33
(Homo
sapiens) 		4 / 6 ASP A 157
ILE A 134
GLU A 148
TYR B 119
 None
 1.26A 2ya7C-4kc3A:
1.0		 2ya7C-4kc3A:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 4kc3 INTERLEUKIN-33
INTERLEUKIN-1
RECEPTOR-LIKE 1
(Homo
sapiens;
Homo
sapiens) 		3 / 3 LYS B 163
ILE A 250
PHE A 239
 None
 0.89A 3j7zS-4kc3B:
undetectable
3j7za-4kc3B:
undetectable		 3j7zS-4kc3B:
16.99
3j7za-4kc3B:
5.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_B_ACTB401_0
(UNCHARACTERIZED
PROTEIN)		 4kc3 INTERLEUKIN-1
RECEPTOR-LIKE 1
(Homo
sapiens) 		4 / 5 VAL B  65
LEU B  72
VAL B  34
PHE B  74
 None
 1.05A 4lb0B-4kc3B:
undetectable		 4lb0B-4kc3B:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4kc3 INTERLEUKIN-1
RECEPTOR-LIKE 1
(Homo
sapiens) 		5 / 12 ALA B  80
PHE B  74
ILE B  57
PRO B  58
LEU B  72
 None
 0.98A 4m6kA-4kc3B:
undetectable		 4m6kA-4kc3B:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4kc3 INTERLEUKIN-33
INTERLEUKIN-1
RECEPTOR-LIKE 1
(Homo
sapiens;
Homo
sapiens) 		5 / 12 ILE B 214
HIS B 314
PHE B 239
ALA B 248
SER A 170
 None
 1.28A 5iwuA-4kc3B:
undetectable		 5iwuA-4kc3B:
20.65